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Biomedical subjects

W Trabert

Publications and source records attributed to W Trabert.

25 records · Page 2Linked to original sources

High-dose steroid therapy in Guillain-Barré syndrome.

In a pilot study, high-dose steroid therapy in acute Guillain-Barré syndrome (GBS) proved to be successful. The pharmacodynamic aspects of this approach appear interesting and worthy of further investigation. An initial dose of 1000 or 500 mg methylprednisolone is recommended which should be given in four divided doses per day. A very slow reduction in the dose is necessary to avoid a relapse. Lack of response correlated with late onset of therapy and high age of the patients.

Adolescent↗

[Severe hypernatremia within the scope of catatonic schizophrenia].

We report the case of a 57-year-old chronic schizophrenic patient who developed an acute catatonic stupor after postoperative withdrawal of neuroleptics with excessive and firstly therapy-resistant hypernatremia. Only after re-treatment with neuroleptics the hypernatremia could be compensated. A relationship between the catatonic schizophrenia and the electrolyte-disturbances can be supposed; probably in both diencephalic structures are involved. Therefore the syndrome of "acute life threatening catatonia" should be included into the differential diagnosis of uncertain metabolic disorders.

Antipsychotic Agents↗

[Dermatozoon delusion in hypoparathyroidism--reflections on the genesis of delusions].

Firstly two female patients with hypoparathyroidism and basal ganglia calcifications are described who developed after long course of illness delusions of parasitosis. The pathological cerebral changes responsible for delusions of parasitosis are mostly localized in the brain-stem. Regarding the two case histories and the former literature the relationship between peripheral paresthesias and a supposed disturbance of central processing is discussed.

Aged↗

Voluntary breath holding in panic and generalized anxiety disorders.

OBJECTIVE: Because breath holding causes arterial pCO2 to increase, we used it to test the hypothesis that in panic disorder (PD) a biological suffocation monitor is pathologically sensitive. METHOD: Nineteen patients with PD, 17 with generalized anxiety disorder (GAD), and 22 normal controls took deep breaths on signal and held them until a release signal was given 30 seconds later. This was repeated 12 times separated by 60-second normal breathing periods. RESULTS: PD patients reported having had in the past more symptoms of shortness of breath when anxious, and more frequent frightening suffocation experiences than the other groups. However, increases in self-rated anxiety between periods of normal breathing and periods of breath holding were similar in all three groups. Skin conductance, blood pressure, and T-wave amplitude reactions to breath holdings were also similar, but heart rate acceleration upon taking a deep breath was greater in GAD patients. Before and after individual breath holdings, end-tidal pCO2 was lower in PD patients than in normal controls; GAD patients were intermediate. Inspiratory flow rate did not differ between groups. CONCLUSIONS: Our physiological results provide no direct support for an overly sensitive suffocation alarm system in PD. Lower pCO2 may be due to anxiety causing hyperventilation in patients prone to panic.

Adult↗

Shared psychotic disorder in delusional parasitosis.

Delusional parasitosis (DP) is associated in 5-15% with shared psychotic disorder (SPD). Little systematic information is available about this particular aspect of the syndrome. A thorough review of all published cases with DP was carried out. 68 case histories of SPD were identified (5.67%). The data of these patients were compared with those of their inducers (n = 44) and with the data of DP patients, who did not transfer their delusional beliefs to others (n = 1,155). Approximately 30% of the psychotic dyads were reported from public health departments. The sex ratio was balanced in the SPD group, but showed a clear preponderance of females in the other two groups. SPD patients and their inducers reported more frequently visual illusions or hallucinations and located the animals correspondingly upon the surface of the skin. No diagnostic differences were found between the inducers and those who had DP but did not induce SPD in others. Albeit 50% of the SPD patients did not receive any treatment except separation from the inducer, the remission rate in this group was 93%.

Adult↗