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Biomedical subjects

W V McKnelly

Publications and source records attributed to W V McKnelly.

5 recordsLinked to original sources
PubMed1983

Case report of withdrawal dyskinesia associated with amoxapine.

The authors describe a case of oral-facial dyskinesia that occurred after discontinuation of amoxapine, and antidepressant which may also have neuroleptic effects. Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.

Amoxapine↗
PubMed1980

Analgesic abuse and the barbiturate abstinence syndrome.

Abstinence syndromes secondary to sedative-hypnotic drugs can occur in a wide range of clinical situations. The first such cases due to a combination analgesic product containing a barbiturate are reported. Cryptic abuse of combination prescription drugs can cause difficult diagnostic problems, such as the abstinence syndromes reported here. Each prescriber should know the individual agents contained in a combination preparation and their potential side effects.

Aged↗
PubMed1978

Use of saliva lithium determinations for monitoring lithium therapy.

During acute and chronic administrations of lithium, 25 patients were studied to determine the effect of other psychotropic drugs on the plasma-saliva lithium concentration correlations. Changes, even discontinuation, in either tricyclic antidepressants or neuroleptics did not affect the plasma-saliva ratio which had an overall correlation coefficient of r = 0.79 (p less than 0.01). The relationship using linear regression analysis was described by the equation, y = 2.27x--0.45. Individual patients' plasma-salivary relations were described by this equation in 87% of cases. The study extends the usefulness of these determinations to include patients on lithium and neuroleptics or tricyclic antidepressants.

Antidepressive Agents, Tricyclic↗