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Biomedical subjects

W Vanscheidt

Publications and source records attributed to W Vanscheidt.

At least 91 records · Page 5Linked to original sources
PubMed1990

Pericapillary fibrin cuff: a histological sign of venous leg ulceration.

The incidence of pericapillary fibrin cuffs was investigated in 49 biopsies of venous leg ulcers and 67 biopsies of leg ulcers of non-venous etiology. Pericapillary fibrin cuffs were seen in 28 biopsies (57.1%) of venous leg ulcers, but only in 11 biopsies (16.4%) of non-venous leg ulcers. In the venous leg ulcers pericapillary fibrin cuffs occurred predominantly near the ulcer surface and around dilated capillaries. Dilation of the capillaries and inflammation probably contribute more to the pathogenesis of pericapillary fibrin cuffs than venous hypertension.

Capillaries↗
PubMed1990

Leg ulcers in a patient with spherocytosis: a clinicopathological report.

In a case of spherocytosis combined with ulcus cruris, Doppler sonography and phlebography revealed a chronic venous insufficiency, together with fibrinous precipitates in capillary and venous vessel walls. Some haemolysis and fragmentation of red cells in the biopsy was also observed. It is suggested that the haemodynamic alteration due to chronic venous insufficiency may have played the main role in the development of the ulcers, although the rheological disturbance caused by the spherocytosis may have had an aggravating effect. Circulatory disorders should be excluded, if skin ulcers are to be classified as haematological disorders.

Aged↗
PubMed1990

[Malleolar and plantar light reflection rheography].

It is reported about the plantar LRR. This modification of the malleolar LRR distinguishes venous healthy from venous patients like the malleolar procedure. By the plantar procedure LRR becomes possible in cases where malleolar LRR is not performable like in larger leg ulcers and lymphedemas. The evaluation of plantar LRR has to regard changed normal values i.e. a prolonged refilling time and an increased delta R.

Foot↗
PubMed1990

[Determination of epidermal growth factor (EGF) receptors in basal cell carcinomas, squamous cell carcinomas and melanomas].

We studied the binding of EGF receptors (EGF-R) in 19 basal cell carcinomas, 8 squamous cell carcinomas, and 9 malignant melanomas. Specific binding of EGF-R was detected in 10 of the basal cell carcinomas, and in all the 8 squamous cell carcinomas. None of the malignant melanomas showed EGF-R binding. A comparative study of the receptor status vs. clinical prognostic data, such as grading and clinical course, did not reveal any significant differences, whereas in ovarian carcinomas, the EGF receptor correlated with the prognosis.

Biomarkers, Tumor↗
PubMed1989

Morphology and localization of sunburst varicosities: an electron microscopic and morphometric study.

The results of light and electron microscopy of 18 punch biopsies of sunburst varicosities are presented. Sunburst varicosities are widened cutaneous veins located within the superficial vessel net as well as within descending branches, often with an asymmetrically thickened wall. The thickened vessel walls contain collagenous and muscle fibers. Only a few elastic fibers have been detected, as opposed to numerous oxytalan fibers. Electron microscopy reveals an interfibrillar collagenous dysplasia, lattice collagen, and some matrix vesicles. The center of sunburst vessels is found at depths ranging from 175 to 382 microns below the stratum granulosum.

Adult↗
PubMed1987

[Does the anesthesia method modify the results of dermatologic surgery of the nose?].

Since dermatosurgery has become a generally acknowledged subsection of dermatology, it seems strange that we have got so little account regarding the influences of anesthesia on the results of plastic surgery in the antrofacial region. A long-term follow-up of 139 patients, who had received regional flaps or free grafts because of tumors of the nose, revealed that the functional and esthetic results of operations carried out in local anesthesia were perfectly comparable with those in general anesthesia. We recommend local anesthesia because of its easy handling and little complications even in elderly polymorbid patients.

Anesthesia, General↗
PubMed1987

[B-scan ultrasound in dermatology].

Using a new polyacrylamide material, ultrasonic B-scanning can now be successfully used to show the upper layers of the skin and its tumors. Examples demonstrate the possibilities of this procedure in daily dermatological diagnostics.

Humans↗
PubMed1986

[Which factors determine early occlusion of aortocoronary venous transplants? An intraoperative analysis of surgical parameters].

From 1978 to 1982 1 364 patients received an aorto-coronary vein graft, reoperations not included. Immediately after the operation the surgeon had to document the intraoperatively taken findings like diameter and quality of the coronary arteries, diameter and quality of the veins, quality of the aorta, bypass-flow according to a standardized protocol. 806 patients could be coronarographied 8 weeks after. The influence of intraoperative findings on the early occlusion of aorto-coronary vein grafts is discussed.

Coronary Artery Bypass↗
PubMedDate not supplied

Reconstitution of basement membrane after 'sandwich-technique' skin grafting for severe burns demonstrated by immunohistochemistry.

Reconstitution of basement membrane structures after "sandwich-technique" grafting of severe deep burns is demonstrated with use of immunohistochemical techniques. Cryosections of human skin after epifascial burn wound excision and sandwich grafting were stained with monoclonal antibodies against type IV and VII collagen, polyvalent antiserum against type VI collagen, and polyvalent antibody against laminin. Standard hematoxylin and eosin histologies were performed for morphologic correlation. Reorganization of the mesenchymal border zone (basement membrane), after transplantation of extremely expanded split-thickness skin autografts overlaid with glycerolized split-thickness skin allografts onto debrided human full-thickness wounds, occurred from day 5 to day 35. The autografts reepithelize the spaces between the mesh structure, which has been covered primarily exclusively with allogenic skin, and form a layered squamous epithelium, with an underlying three-dimensional basket-weave array of collagen in the remodeled neodermis after epifascial excision. Immunochemical techniques detect the reconstitution of a basement membrane zone with a typical architecture and distribution of laminin, type IV, and type VII collagen being built up 1 week to 5 weeks after sandwich grafting. These structures can be seen in the autografts during the first 2 weeks and are consistent in the whole reconstituted skin after day 35. To our knowledge this is the first report of the expression of type VI collagen in these types of wounds. The findings are compared with the expression of type VI collagen in healthy skin. The results indicate that the modified sandwich-grafting technique is an adequate means for early burn wound closure and resurfacing of third-degree burn wounds and leads to the reconstitution of dermal qualities.

Basement Membrane↗
PubMedDate not supplied

EMLA anaesthetic cream for sharp leg ulcer debridement: a review of the clinical evidence for analgesic efficacy and tolerability.

Sharp debridement is a fast method of achieving a clean leg ulcer, which promotes healing and enables skin grafting. EMLA cream is the only topical anaesthetic for which there is clinical evidence of analgesic efficacy for debridement. Thirteen clinical investigations of EMLA are reviewed. Four double-blind studies and one open randomised controlled study show that EMLA applied to the ulcer for 30-45 min under occlusion significantly reduces the pain from sharp debridement, decreases the incidence of post-debridement pain and reduces the time needed to achieve a clean ulcer, giving potential savings in healthcare costs. Doses of up to 10 g EMLA result in plasma levels of lidocaine and prilocaine well below toxic levels. Repeated treatment does not change the bacterial flora of the ulcer and rarely causes sensitisation. The treatment of pain in leg ulcer patients is important for patient satisfaction and for patient-perceived quality of life.

Administration, Cutaneous↗