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Biomedical subjects

W W Hinchey

Publications and source records attributed to W W Hinchey.

5 recordsLinked to original sources
PubMed1989

Angiomatoid malignant fibrous histiocytoma: flow cytometric DNA analysis of six cases.

Using flow cytometry, we examined the DNA content of six angiomatoid "malignant" fibrous histiocytomas (AMFH), seven nonangiomatoid MFH, and seven myxoid variants of MFH. All six AMFHs were diploid. All nonangiomatoid MFHs and six of seven of the myxoid variant were aneuploid. The clinical course, histological appearance, and ploidy pattern of AMFH are distinctly different from other MFH variants. These differences strongly suggest that AMFH is at the benign end of the clinicobiologic spectrum manifested by "malignant" fibrous histiocytomas.

Adolescent↗
PubMed1983

Hyperinsulinemic hypoglycemia in adults with islet-cell hyperplasia and degranulation of exocrine cells of the pancreas.

Five adults with pancreatic islet-cell hyperplasia presenting as hyperinsulinemic hypoglycemia are reported. Additional insular lesions including nesidioblastosis, adenomatosis, and insulinoma were variably present. This apparent spectrum of islet-cell lesions has been rarely noticed in hypoglycemic adults, although it is a recognized cause of a similar clinical syndrome in children. B-cell hyperplasia was confirmed in all five cases by histochemistry, immunochemistry, and electron microscopy. In addition, nodules of eosinophilic exocrine cells, another recently recognized finding in similar cases, were present in all cases studied. Ultrastructural study revealed that these nodules were composed of degranulated acinar cells. These acinar changes may provide a diagnostic aid in cases of pancreatic endocrine hyperplasia. Consideration of the embryologic development of the pancreas suggests that this spectrum of islet-cell hyperplasia and acinar cell change is due to neoformation of islets from ducts. The etiologic factors of such proliferation are still unknown.

Adenoma↗
PubMed1983

Paravaginal wolffian duct (mesonephros) adenocarcinoma: a light and electron microscopic study.

This is a report of an adenocarcinoma of mesonephric origin studied by light microscopy, electron microscopy, and immunocytochemistry. Unlike previous reports, our lesion was located paravaginally and not in the leaves of the broad ligament or in the cervix. The light microscopic features are similar to those of previous cases in the literature. Although not specific, the ultrastructural features of the tumor are similar to those of mesonephric structures and different from those of müllerian structures. The diagnosis always should be considered when a tumor occurs at the site where mesonephric remnants may be found and after exclusion of a carcinoma of other pelvic organs or a metastasis from a primary neoplasm elsewhere.

Adult↗
PubMed1981

Cryptococcal prostatitis.

A case of granulomatous prostatitis due to Cryptococcus neoformans is reported. The patient, who had a history of diabetes mellitus and chronic active hepatitis, had symptoms of prostatic hypertrophy. Tissue obtained from surgery showed granulomatous prostatitis, and a cryptococcal organism was identified by special stains. Postoperative cultures grew Cryptococcus neoformans, and the patient was treated successfully with surgery and a short course of amphotericin B. After nine months of follow-up, there is no evidence of systemic infection.

Amphotericin B↗