The Papanicolaou smear. Medicine's most successful cancer screening procedure is threatened.
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Biomedical subjects
Publications and source records attributed to W W McLendon.
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Automation streamlines a previously labor-intensive process and virtually eliminates sampling or labeling errors. The techniques of molecular biology and genetics continue to assist the physician in the diagnosis, prognosis, and treatment of patients with neoplastic diseases.
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Image analysis and flow cytometry are complementary methods in assessing the DNA content and proliferative capacity of a tumor. In prostatic adenocarcinomas, DNA aneuploidy is associated with poor outcome. The current 21 days for identification of mycobacteria and 28 days for susceptibility testing should be reduced in the coming years.
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A brief historical overview of pathology's role in the evolution of modern medicine is presented by highlighting the contributions of three outstanding figures in the history of pathology. Morgagni developed the concept of clinical-pathological correlation as a means of understanding "the seats and causes of diseases". Virchow introduced the microscope to pathology as a means of better understanding disease through the study of cellular (and eventually subcellular) events. Welch applied the then-new approaches of bacteriology to the study of disease and established the laboratory as a central focus for the pathologist. Certain common themes in the lives and works of these three founders are analyzed with respect to their signification for pathologists today and in the future.
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