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W W Wooten

Publications and source records attributed to W W Wooten.

8 recordsLinked to original sources
PubMed1995

SPECT of the cervical spine in the evaluation of neck pain after trauma.

In a retrospective study, the authors reviewed the use of SPECT in the evaluation of cervical spine abnormalities in 35 patients with persistent neck pain after trauma. Nineteen patients had normal bone SPECT studies, which, in addition to several volunteers, were used to identify tomographic landmarks and determine resolution of individual vertebrae. Sixteen patients had abnormal SPECT results. When compared to final diagnosis, this group included seven (44%) patients with recent fractures, five (31%) patients with traumatic periostitis (periosteal injury resulting from severe strain), and four patients (25%) with mild cervical strain superimposed on degenerative changes. SPECT sensitivity in the detection of recent fractures was 100% with a specificity of 78%. SPECT detected occult fractures in 7 of 35 patients (27%), including 3 patients with normal radiographs and 4 patients with equivocal radiographs. Recent fractures were excluded in six of nine patients (67%) with known fracture identified on cervical spine radiographs and none of the patients with normal SPECTs had CT or MRI evidence of recent fractures. SPECT was useful in 1) the diagnosis of occult fractures or periostitis (periosteal injury) in patients with normal radiographs, 2) characterization of radiographic abnormalities (recent versus healed fractures), 3) identification of active, possible post-traumatic osteoarthritis superimposed on chronic degenerative disease, and 4) eliminating or targeting subsequent imaging modalities, when appropriate. The authors conclude that bone SPECT has a valuable place in the diagnostic evaluation of patients with persistent neck pain after trauma.

Adolescent↗
PubMed1988

Technetium-99m MAG3 kit formulation: preliminary results in normal volunteers and patients with renal failure.

Previous studies have shown that [99mTc]mercaptoacetyltriglycine (MAG3) purified by high performance liquid chromatography (HPLC) is a very promising new renal imaging agent which has characteristics very similar to [131I]orthoiodohippurate. An easily prepared kit formulation has been developed and evaluated in ten normal volunteers and three patients on hemodialysis. The average radiochemical purity was 96.6%. There were no adverse reactions. In the volunteers, the relative uptake +/- 1 s.d. was 49.1% +/- 2.6% for the right kidney and 50.9% +/- 2.6% or the left kidney. Urine activity was 71.4% +/- 6.4% of the injected dose at 30 min and 94.4% +/- 2.2% at 180 min. The 60-min plasma clearance was 340.0 +/- 79.0 ml/min and the volume of distribution was 5.15 +/- 1.1I. Approximately 0.5% of the injected dose was present in the gallbladder at 30-60 min postinjection. Gut activity was not present 30-60 min postinjection but reached 1% of the injected dose by 3 hr. In the hemodialysis patients, approximately 1% of the injected dose was present in the gallbladder and 0.5% in the gut at 30-60 min; gut activity increased to approximately 5% at 3 hr. In summary, results using the kit formulation compare favorably to previously published data using the HPLC purified material. Based on these preliminary results, the kit formulation is expected to have widespread clinical utility.

Adult↗
PubMed1987

Technetium-99m imaging of bone trauma: reduced sensitivity caused by hydrocortisone in rabbits.

This study evaluates the effect of hydrocortisone on the sensitivity of 99mTc-scintigraphy for the detection of bone trauma in three groups of rabbits: a control group that received no hydrocortisone, a low-dose group that received 0.8 mg/kg/day, and a high-dose group that received 20 mg/kg/day. Scintigrams of the tibial diaphyses were obtained at 48 hr, 1 week, 2 weeks, and 3 weeks after surgical creation of a simulated fracture (a 1.5-mm hole in the cortex). The mean sensitivity for detecting fractures in control animals was 95% at 48 hr and 100% at all other times. Mean sensitivity for rabbits given the high dose of hydrocortisone was 41% at 48 hr. Mean sensitivity for the low-dose group was 75% at 48 hr, but this was not significantly different from the control group. Sensitivity in both groups treated with hydrocortisone improved with time. At 3 weeks, the mean was 93% in the low-dose group and 83% in the high-dose group. These data suggest that 99mTc scintigraphy may be less sensitive in detecting bone trauma in patients on glucocorticoid therapy than in patients in the general population.

Animals↗
PubMed1983

Radionuclide kinetics in MIRD dose calculations.

A recent case report is reviewed and an alternative model for the radionuclide kinetics is presented; it estimates in an absorbed dose differing by a factor of two from the published calculation. Both models are consistent with observed data. Within a compartment model, one may choose to monitor a compartment of interest directly, or to monitor another compartment and (indirectly) solve for the activity in the compartment of interest. Advantages and disadvantages are reviewed.

Humans↗