Biomedical subjects
Publications and source records attributed to W Ware.
Randomization tests have been proposed as a statistical method for analyzing the data from single-case designs. A case is made for incorporating a responsive element into randomized designs. A partially responsive, partially randomized single-case design is presented, and an example is given to illustrate the design and the corresponding randomization test.
Fourier transform infrared (IR) spectroscopic studies of phosphatidylserine/cholesterol/Ca2+ complexes are reported using the synthetic phosphatidylserines (PS) 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS), and 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine (DMPS). IR spectra reveal that cholesterol does not significantly alter the binding nature of Ca2+ to PS molecules; Ca2+ binds to the phosphate ester group of PS in the presence of cholesterol up to 50 mol% as in the case of pure PS bilayers. However, the IR data indicate that the presence of cholesterol induces disorder of the acyl chain packing, increases the degree of immobilization of the interfacial and polar regions, and increases the degree of dehydration of the PS/Ca2+ complexes.
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