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Biomedical subjects

W Weddington

Publications and source records attributed to W Weddington.

6 recordsLinked to original sources
PubMed2001

Auditory working memory in HIV-1 infection.

We evaluated auditory working memory in 41 HIV-seropositive (HIV+) and 37 HIV-seronegative (HIV-) male drug users, employing a modified version of the Letter-Number Span Task developed by Gold and colleagues. We added a control condition to the standard task in order to evaluate more directly the contribution of the processing component to the working memory deficits with the effects of storage demands minimized. HIV+ subjects performed significantly more poorly compared to controls on an index of working memory processing derived from raw scores obtained under the two testing conditions. These findings are consistent with our previous reports that HIV-related working memory deficits are evident across multiple informational domains; further, the deficit appears to involve multiple-component functions of working memory. Converging findings from recent working memory studies and from primate and neuroimaging investigations suggest that functional abnormalities of prefrontal cortex should receive greater emphasis in models of neurocognitive aspects of HIV-1 infection, which have typically emphasized "subcortical" deficits.

AIDS Dementia Complex↗
PubMed1997

The impact of culture on physician stress and coping.

In a qualitative research study, a group of 10 community-based practicing family physicians were interviewed to determine their career values, sources of stress, and methods of coping. Research participants were identified as healthy and satisfied with their careers. To maximize the sample's diversity and determine potential racial differences in physician stress and coping, two African-American family physicians were requested to participate in the study. In this sample group, stress often was produced when a conflict existed between the person and the work environment. Stress also was created if values were manifested in unhealthy and unbalanced ways. Research participants described various learned strategies that enabled them to cope more effectively. An Africentric perspective, which emphasizes group needs and family values, distinguished the presentations of the African-American physicians. Results suggested that culture is a significant variable of influence in how stress and coping is experienced, and that assessing developmental processes in stress and coping is important.

Adaptation, Psychological↗
PubMedDate not supplied

delta 9-Tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A pilot study.

We conducted a pilot study to ascertain the potential toxicity and possible efficacy of delta 9-tetrahydrocannabinol (THC) at the oral dose of 5 mg/m2. Over one third of the study population, which consisted of 25 patients, reported significant dysphoric reactions. Four patients (16 per cent) elected not to take THC rather than experience loss of motivation which interfered with their professional life. Paradoxically, on eight occasions nausea seemed to worsen with THC. After the first administration of THC, 18 patients (72 per cent) described less nausea and only two individuals (8 per cent) noted complete resolution of nausea. Two patients reported worsening of their nausea. Eighteen patients noted less vomiting (69 per cent) after the first administration of THC and four patients (15 per cent) reported completed resolution of their vomiting. By the third administration of THC, one of 14 patients (7 per cent) and two of 14 (14 per cent) noted complete alleviation of nausea and vomiting, respectively. Patients who scored high on the Brief Psychiatric Rating Scale, who reported euphoria, or who had psychogenic nausea and vomiting were most likely to have a favorable antiemetic response. The results of this pilot study suggest that orally administered THC is a toxic but transiently effective antiemetic when administered at 5 mg/m2.

Adult↗