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Biomedical subjects

W Wegner

Publications and source records attributed to W Wegner.

At least 19 recordsLinked to original sources
PubMed1992

Immunomodulatory activity of different blood products on the mitogen-induced human lymphocyte transformation.

Blood transfusions have an immunosuppressive effect on the recipient and induce changes in several immunological parameters. We studied the effect of homologous and autologous fresh plasma (FP), fresh frozen plasma (FFP), heparinized plasma, as well as the influence of red blood cells (RBC), CPDA-1, CPD, heparin, PAGGS-mannitol, SAG-mannitol and ADSOL on mitogen-induced lymphocyte transformation. Both homologous and autologous FP and FFP decreased the PHA and ConA response of human lymphocytes (P < 0.05). The PWM response was reduced by FP (P < 0.05). The mean t1/2 of plasma-induced suppression was approximately 38 h. Dose-dependent suppression rates were observed with pure CPDA-1 and CPD solutions. In contrast, heparinized plasma showed an elevated PHA- and ConA-induced transformation rate (P < 0.025), whereas PWM induction was unaffected. In addition, washed RBC, pure PAGGS-M, SAG-M and ADSOL solutions revealed no effect on the PHA response. Freezing, heating or recalcification of plasma resulted in an increase in the PHA response. Adenine was not immunosuppressive in vitro. We conclude that, in addition to unspecific mechanisms by CPDA-1 or CPD, an unknown plasma factor, which is susceptible to changes in temperature or storage conditions, suppresses the PHA-, PWM- or ConA-induced T-cell immune response. Further clinical studies are needed to correlate these observations with clinical phenomena.

Adenine↗
PubMed1992

[Effect of plasma and plasma components on lymphocyte transformation].

Blood transfusions have an immunosuppressive effect on the recipient and induce changes of several immunological parameters. We therefore studied the effect of homologous and autologous fresh plasma, fresh-frozen plasma, heparinized plasma, as well as the influence of i.v. immunoglobulins on the MLC- and mitogen-induced lymphocyte transformation. We conclude from our study that, besides unspecific mechanisms, an unknown plasma factor enriched in the immunoglobulin fraction suppresses the MLC- and mitogen-induced T-cell immune response.

Humans↗
PubMed1992

[The problem of breeding for spots in rabbits. 2. Further results on the variation of characteristics in fattening and breeding animals].

The mode of inheritance of spotting in both breeds (ES and DRS) is compatible with incompletely dominant resp. intermediate segregation, though a broad variability of spotted areas exists, indicating the influence of minor genes or other ontogenetic factors. Additional findings support the conclusion, that there is a very distinct predisposition of homozygous KK animals to develop megacolon with growing age. This also has consequences for the relative organ weight of the heart and of the adrenals in this genotype. Sporadically encountered accessory adrenal cortical tissue however did not exhibit genotypic preferences.

Adrenal Glands↗
PubMed1978

[Eye changes in the merle syndrome in the dog (author's transl)].

In 44 dachshunds of both sexes, reared and held under identical conditions in order to investigate the effects of the merle gene, ophthalmologic examinations were performed. Eleven extreme dapples with a cutaneous depigmentation beyond 50% (homozygous merle animals, MM) exhibited severe defects in variable forms: Microphthalmia and microcornea, microcoria and corectopia, cataracts and colobomas, rudimentary lenses and ectasia of episcleral vessels. In heterozygous merles with a white percentage of coat color beneath 50% (Mm), lacking tapetum lucidum, depigmented retina, papillary anomaly and ectasia of episcleral vessels were stated, as well as in MM-animals, though not in all. These findings are interpreted as obvious gene dosis effects of the incompletely dominant merle gene which is used to produce a characteric harlequin dappling in many breeds of dogs. With the exception of ectasia of episcleral vessels in a few animals, the homozygous well pigmented controls (mm) displayed none of the anomalies mentioned. The meaning of these results for comparactive medicine and animal protection is discussed.

Animals↗
PubMed1976

[Some mechanical properties of the pig aorta (author's transl)].

In a machine for tensile tests the ultimate strength, stress and strain of the aorta ascendens of 47 female pigs (German landrace) at three different regions of the vessel wall were determined. The animals were fattened under identical conditions in a progeny testing station and slaughtered at the same living weight (102 +/- 2 kg). Weak regressions of body weight and age on parameters measured were nevertheless accounted for. The average elastin content of the aorta ascendens diminished with advancing age but was not significantly correlated to biomechanical properties of the three single samples. Maximum load, stress and modulus of vessel wall segment I (stamped out nearer to the heart) was greater than in sample II. These circumferential segments however exhibited highly stronger biomechanical resistance than sample III, which was stamped longitudinally. In samples I and II there was a negative correlation between thickness of the wall and ultimate tensile stress (N/mm2). Freezing of the material prior to test at -18degrees C for one week resulted in a significant rise in ultimate tensile strength and stress. The meaning of these findings for comparative angiology is discussed.

Age Factors↗