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W Weis

Publications and source records attributed to W Weis.

7 recordsLinked to original sources
PubMed1991

Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat.

Platelet activating factor (PAF) induces neutrophilia and produces a variety of gastrointestinal lesions. The role of PAF as a proinflammatory mediator was examined by measuring the production of PAF and the efficacy of the PAF antagonists WEB 2086 and Ro 24-0238 in acetic acid (HOAc)-induced colitis. PAF levels within the colonic mucosa, as measured by radioimmunoassay, increased from 259 +/- 119 ng/mg in control tissue, to 616 +/- 266 ng/mg in HOAc inflamed tissue. The accumulation of neutrophils within the mucosa was decreased by 53 +/- 10% by pretreatment with 3 mg/kg WEB 2086, and by 43 +/- 11% by 3 mg/kg Ro 24-0238. PAF-induced neutrophilia had no effect on the severity of HOAc-induced colitis, therefore, PAF my be involved in sustaining the chronic inflammation of colitis.

Acetates↗
PubMed1978

Participation of L-ascorbate:ferricytochrome b5 oxidoreductase in ascorbate-dependent fatty acid desaturation of rat liver microsomes.

The microsomal enzyme ascorbate-cytochrome b5 reductase participates in the ascorbate-dependent fatty acid desaturation. Three pieces of evidence are given for this statement: 1) Comparison of the rate of ascorbate-dependent oleate formation with the rate of reduction of cytochrome b5 in microsomes and in the isolated detergent form shows that only the enzymatic reduction of cytochrome b5 is fast enough to support oleate formation; 2) added enriched ascorbate-cytochrome b5 reductase increases the rate of return of stearoyl-CoA oxidised cytochrome b5 back to the reduced state; 3) addition of enriched ascorbate-cytochrome b5 reductase increases the rate of ascorbate-dependent oleate formation in rat liver microsomes.

Animals↗