[Chronic pancreatitis. 2. Clinical aspects and complications].
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Biomedical subjects
Publications and source records attributed to W Wermke.
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In the past decade the sonography has effected radical changes in the diagnostics of gallstone troubles and their complications. Today it is the method of choice in search for gallstones. Taking into consideration all advantages connected with the method and a sensitivity of more than 95% with an approximately 99 per cent specificity at present no other diagnostic method can compete with it. The reliability in the gallstone diagnostics above all depends on the experience of the investigator and the size of the concrement. Data in modern literature indicate a sensitivity of 70-90%, among our own patients it is in 376 cases nearly 86% (specificity 92%). In optimal technical and personal prerequisites the ultrasound diagnostics it is the initial method of choice also in the diagnostics of the bile ducts. The intravenous cholegraphy and ERC as complementary methods are used only in the second place.
An examination of esophageal function using manometric techniques and long-term pH measurement was carried out on 14 patients suffering from cirrhosis of the liver who had esophageal varices. The resting pressure in the lower esophageal sphincter was found to be slightly reduced in 50 per cent of those examined, while 100 per cent showed a slightly reduced contraction amplitude in the distal tubular esophagus which became progressively lower in the distal direction, and a pathological gastro-esophageal reflux was observed in 57 per cent. We were able to carry out a control examination on 10 of these patients after sclerosing procedure. Sclerotherapy was found to have lowered resting pressures in the lower esophageal sphincter in 80 per cent of those patients, while all of them showed a grossly impaired tubular peristalsis in the form of simultaneous, mostly repetitive contractions with a considerably lowered contraction amplitude, however it had no negative influence on gastro-esophageal reflux patterns.
In a retrospective analysis, the sonographic findings of 125 patients with prehepatic portal hypertension (of these 76 with condition after varix bleeding) were evaluated. The main cause were portal venous thromboses after umbilical venous catheter; 98% of these patients had a case history of hemorrhages. Of 113 cases with portal vein thrombosis, 54% had a cavernomatous transformation of the portal vein, 87% of them had a varix hemorrhage. In 12 patients with isolated lienal vein stenosis, no hemorrhage had occurred so far. All portal vein thromboses were correctly diagnosed by sonography. Besides the detection of thromboses, only in 5% of all cases no sonographically identifiable collaterals of the portal system were present; such collateral vessels could be imaged in 94% of the patients with endoscopic detection of varices. Sonography can be used as a screening method in suspicion of portal hypertension of prehepatic origin.
To evaluate sonographic accuracy in the diagnosis of choledochal calculi 490 patients with cholestasis were examined prospectively with real-time scanner before ERCP or surgery. Ultrasound detected duct stones in 177 of 222 patients (sensibility 80%) and their absence in 242 of 268 (specificity 90%). Dilated extrahepatic bile ducts were demonstrated via ultrasound in 84% of cases with choledocholithiasis, dilated intrahepatic bile ducts in 57%. Intestinal gas obscuring the distal common duct was the most important factor limiting the ability of ultrasound to detect duct stones.
The sonographic findings in 274 patients with biliary obstruction and/or dilatation of the pancreatic duct of more than 4 mm were evaluated (128 common duct stones, 82 carcinoma of pancreas, 64 chronic pancreatitis). Carcinoma of the pancreatic head caused a greater degree of dilatation of the common bile duct (average diameter 18.3 mm) than did chronic pancreatitis (10.5 mm) or biliary stones (14.2 mm). Dilatation of the pancreatic duct greater than 4 mm occurred with approximately equal frequency with carcinomas (59%) and chronic pancreatitis (64%); it was found in only 1.6% of biliary duct stones. Dilatation of intra-and extra-hepatic bile ducts and hydrops of the gall bladder was significantly higher with carcinoma of the pancreas than in chronic pancreatitis.
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