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Biomedical subjects

W Wetzel

Publications and source records attributed to W Wetzel.

At least 91 records · Page 5Linked to original sources
PubMed1978

Avoidance reaction of painful stimulation of another rat: effect of methylglucamine orotate.

An avoidance reaction to painful stimulation of another animal was developed in rats. Two hundred twenty-five mg/kg methylglucamine orotate was injected intraperitoneally each day, 1 hr before the training session. The orotate treated rats showed an accelerated development of the avoidance reaction during 5 days of training. Depending on the experimental conditions, extinction of the reaction was delayed in orotate treated rats, compared to saline controls. The results from these experiments, using neither footshock punishment nor food reward as reinforcement, give further evidence for the improvement of long term memory by orotic acid.

Animals↗
PubMed1978

[The continent colon-conduit stoma].

A conduit occlusor is presented consisting of a tube surrounded by foam rubber and covered by a latex membrane, with a polyurethane cap attached to the other end. A valve imbedded in the cap allows voluntary urine drainage. This atraumatic, pneumatic, non-invasive occlusor device was used quite succesfully in 3 volunteers who had had a colon conduit urinary diversion. The device was well-tolerated, leakage was effectively prevented. Further experience, however, will be necessary for final evaluation.

Humans↗
PubMed1976

Is actinomycin D suitable for the investigation of memory processes?

The influence of Actinomycin D (AMD) applied intrahippocampally at doses of 1-6 mug/animal, on the acquisition and retention of a shock-motivated brightness discrimination was studied on rats in a semiautomatic Y-maze. The injection of AMD 4 hr prior to training did not influence the acquisition, but causes, dose-dependent, a retention loss in relearning 24 hr after training. Twenty-eight hr after AMD application, naive rats exhibited a deterioration of acquisition performance increasing equally with the dose. At the same time, both circumscribed necroses in the hippocampus and signs of a general intoxication were observed. Considering the described pro- and retroactive effects, it is concluded that the use of the inhibitor AMD in learning experiments is not suitable to provide reliable evidence of the specific importance of the cerebral RNA synthesis for memory consolidation.

Animals↗
PubMedDate not supplied

Toxic megacolon secondary to pseudomembranous colitis.

Toxic megacolon has rarely been reported in the course of antibiotic-induced pseudomembranous colitis. We have been able to collect 20 cases from the literature and add one new case. The mortality in the collected series was 33 per cent. The critical factor in improving survival is early recognition of the pseudomembranous colitis. Most patients can be managed medically by removal of the offending antibiotic, bowel rest, vancomycin, and steroids. If toxic megacolon develops in the face of appropriate medical management, an aggressive surgical approach is indicated, as with ulcerative colitis. Subtotal colectomy appears to be the procedure of choice.

Adult↗
PubMedDate not supplied

Effects of [des-Tyr-D-Phe3]beta-casomorphin (2-5) on sleep pattern in rats.

The effects of the antidepressant-like acting peptide [des-Tyr-D-Phe3]beta-casomorphin(2-5) (Pro-D-Phe-Pro-Gly, BCH-325) on sleep were studied in rats. The rats received subcutaneous injections of BCH-325 in acute experiments (doses: 4, 20, 100, 500 and 2500 nmol/kg) and in a 10-day chronic experiment (50 nmol/kg/day). Acute administration of 20 and 100 nmol/kg enhanced wakefulness, 500 and 2500 nmol/kg enhanced paradoxical sleep, and 4 nmol/kg had no effect. Chronic administration resulted in an increase of paradoxical sleep during the first 5 days of drug treatment. Thus the sleep effects of BCH-325 differ from those of typical antidepressants and other psychotropic drugs.

Animals↗
PubMedDate not supplied

Evaluation of laser sclerostomy fistulas using ultrasound biomicroscopy.

BACKGROUND: Laser sclerostomy is a relatively new technique in glaucoma surgery. Clinical examination, particularly of the intrascleral part of laser sclerostomy fistulas, is difficult. We performed ultrasound biomicroscopy (UBM) in order to determine, if it were possible to visualize fistulas. Moreover, it was the aim to investigate whether this imaging technique could provide additional information on fistula morphology. PATIENTS AND METHODS: Ten eyes of eight patients with chronic open angle glaucoma who had undergone erbium-YAG laser sclerostomy ab externo were examined using a UBM-probe with a 20 MHz transducer providing spatial resolution of approximately 80 microm. RESULTS: Radial scanning allowed visualization of the sclerostomy fistula in nine of ten eyes. The different functional state of sclerostomy fistulas correlated well to UBM findings. It was possible to image differences in the morphology of occluded and patent fistulas and to visualize the filtering pathway in functioning blebs. CONCLUSIONS: Ultrasound biomicroscopy allows imaging of laser sclerostomy fistulas. UBM and clinical findings correlated well in the majority of the patients we examined. The technique supplements clinical examination and in some cases may provide additional information.

Aged↗