[A methodological contribution on the determination of distribution ratios of biologically active compounds in a benzene/water system].
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Biomedical subjects
Publications and source records attributed to W Weuffen.
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Thiocyanate-ions are ubiquitous in living nature. They are important for the cell-function and the ongoing of vital functions. Therefore they are an essential factor in both, animal and human being. The Thiocyanate-ions are brought in alimentary but also built by the organism itself. Beneath the guarantee for many different body-functions Thiocyanate-ions are an important part of the immune response. To that belongs their involvement in H2O2-Thiocyanate Peroxidase-Systems. Furthermore Thiocyanate-ions are agents for cell-protection and for the repair-mechanism of the host in the struggle with toxic substances of germs. Therefore they also have a tumour-prophylactic effect. Thiocyanate-ions participate at physiochemical reactions which due the protein-conformation. There are hypothesis that a deficiency of Thiocyanate-ions may be a co-factor for causative agents of diseases such as Cystic Fibrosis and Transmissible Spongiform Encephalopathia. References for calculations of the alimentary balance are given, if deficiency of Thiocyanate-ions occurs. From the view of an optimal animal-feeding the sufficient alimentary supply of Thiocyanate-ions and their precursors is mentioned.
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Adult sheep were administered 12 mg thiocyanate (SCN-)/kg body weight orally twice a year in altogether 16 respectively 41 single doses under conventional keeping during the period of stabling (winter) in two consecutive years. Fattening lambs got an analogous SCN- dosage with altogether 4 respectively 34 single doses under intensive keeping. Aided by this temporarily obtained balance of an alimentary SCN- deficiency the following effects were reached during conventional keeping: Significant increase of the wool mass in the greasy state and a tendency to better breading performance. During intensive fattening an increase of the wool mass and of the staple cross-section was proven statistically in the mean for all the test animals, but for the increase of the staple length it could be shown only by comparison of twins.