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Biomedical subjects

W Wiegand

Publications and source records attributed to W Wiegand.

14 recordsLinked to original sources

The optic nerve pathology in magnetic resonance imaging.

Magnetic resonance imaging (MRI) delineates the orbital soft tissue excellently and is a valuable diagnostic tool in optic nerve pathology. By using different imaging parameters some examples are shown of demarcation of optic nerve tumors, optic nerve inflammations and orbital diseases surrounding the optic nerve. Whereas CT appears to be superior to MRI only in the detection of calcified perioptic meningiomas, MRI provides unique visualization of optic canal and even subarachnoidal space of retrobulbar optic nerve in peculiar cases.

Cranial Nerve Neoplasms

[Anophthalmos. Sequela of an unusual birth injury].

A child is reported who was born with complete absence of the right globe after instrumental delivery. The delivery was difficult and had been carried out by application of suction cup and forceps. The clinical examination at our hospital some days after the delivery suggested accidental enucleation during birth. In addition to anophthalmia, only minor laceration of the conjunctiva, a hematoma of the lids and a skin wound close to the right cheek were present, but no further orbital injuries. In earlier literature, similar injuries with luxation of the globe during delivery have been reported but they were usually associated with heavy periorbital injuries.

Anophthalmos

[Retinitis photoelectrica caused by electro-welding].

The authors report on a student who developed bilateral photoretinitis as a result of failing to use a welding shield properly while arc-welding. The case is unusual in that no symptoms of photophthalmia occurred at any time. The course of the accident is described and the special features of the case are discussed.

Accidents, Occupational

[Eye manifestations in borreliosis--bilateral panuveitis with exudative retinal detachment].

Lyme disease, a tick-borne infection with the spirochete Borrelia burgdorferi, can lead to various different organ manifestations. Severe ocular effects however, have until now been rare. The case of a 20-year-old woman is reported, who developed systemic illness (headache, nausea, vomiting, fever, diarrhea) and severe bilateral panuveitis with exudative retinal detachment about 2-3 weeks after several insect bites. The case history, clinical course, and serological examinations suggest an infection with B. burgdorferi. Later on, the fluorescein angiography results and clinical picture were suggestive of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). The etiology of this disease is unknown so far, but it may be possible that infections with B. burgdorferi are of etiological significance.

Adult

[Neutron spin tomography of the optic nerve in retrobulbar neuritis and optic nerve atrophy: demonstration of inflammation and demyelination].

Detection of inflammatory lesions of the optic nerve by magnetic resonance imaging requires a special imaging technique. In 3 patients with persisting visual loss due to retrobulbar neuritis we scanned the optic nerve with a short inversion recovery sequence. In each of the 3 patients magnetic resonance imaging revealed inflammatory lesions in the intracanalicular portion of the optic nerve. It is supposed that the unfavorable location of the lesions in the optic canal is responsible for the poor recovery of visual acuity. In another patient with a bilateral optic nerve atrophy demyelination of the optic nerve could be made visible.

Adult

Changes of diameter and length in cylindrical segments of canine femoral arteries during activation at different pressures.

Changes in diameter and length of cylindrical segments of canine femoral arteries were recorded at different transmural pressures, and these dimensional changes have been compared with those of rings and longitudinal strips of the vessel wall. The segments responded to stimulation (noradrenaline or 40 mmol/l of potassium) with a reduction of the diameter at all transmural pressures applied. The length of the segments increased during stimulation when the transmural pressure was zero, but decreased at higher transmural pressures (60-70 mm Hg). This shortening at normal transmural pressure was converted to a small lengthening when the segment was stretched to in situ length. The factors determining these responses are discussed.

Animals

Complications of retinal xenon-arc photocoagulation.

The perioperative complications of xenon-arc photocoagulation of 245 eyes of 165 patients were reviewed. The follow-up ranged from 5 days in case of no complication to 5-30 days in case of complications. In 210 eyes (approximately 86%) photocoagulation could be carried out without any complication. Severe complications occurred in only 8 cases (approximately %). Among these were retrobulbar hematoma, keratopathy, secondary glaucoma, and persistent choroidal detachment. The number of burns per eye was of minor influence to the occurrence of complications.

Adult

[Possibilities for the demonstration and differentiation of eye muscle changes in endocrine orbitopathy and ocular myositis using nuclear magnetic resonance tomography].

Nuclear magnetic resonance (NMR) tomography is a new imaging technique which at present is still not very common in ophthalmology. Improvement of contrast and resolution by use of surface coils produces high-quality pictures which open up completely new possibilities in orbital diagnosis. This article explains the procedure and describes its use in some cases of Graves' disease and ocular myositis. Differential diagnostic possibilities in orbital diseases are discussed.

Adult