Biomedical subjects
Publications and source records attributed to W Wierzchowski.
A patient in age 68 years with malignant fibrohistiocytoma of the larynx was surgically treated in the department of Otolaryngology, Medical University in Cracow. Fibrohistiocytoma is very rare tumor of the larynx. The diagnosis was supported by immunohistochemical examination. In the course of treatment were observed local relapses and neck metastases.
In prospective studies specimens of the large bowel were obtained from 733 autopsy cases. After fixing they were examined under illuminated magnifying lens and all polypous lesions were excised for histological analysis and classified according to Correa's criteria (8). Adenomatous polyps were found in 280 cases (38.2%) and their prevalence increased with age in both sexes. Adenomatous polyps, also multiple were found most frequently in the transverse colon, and then ascending colon, sigmoid, descending colon and rectum. The mean number of adenomatous polyps per positive specimen was 2.33 for men and 2.60 for women. In 6.8% their diameter was > or = 10 mm. The prevalence of polyps with severe degree of dysplasia (III degree) increased from proximal to distal segments of the colon in both sexes and their prevalence is significantly higher in the ascending colon in women. In the whole series there were 6 adenocarcinomas of 5-18 mm in size, all in women over 80 years of age. The results of the present study were compared with the data concerning other populations of the world. In the light of a repeatedly confirmed a generally accepted relationship between adenoma and adenocarcinoma of the large intestine the results of our study seem to underestimate the prevalence of colon adenocarcinoma in the population of Cracow and Cracow district.
Wistar rats were implanted subcutaneously with samples of the home-made metacrylate material Akpol S and, for comparative purposes, with samples of the imported materials Trevalon and Superacryl. Throughout a period of 7 weeks, at 7-day intervals, sections of the tissues surrounding implants were collected from the animals and examined histopathologically. No differences in the character of the inflammatory reaction ensuing around the implants made from the three tested materials were observed. The dynamics of increase in the thickness of a pseudocapsule which developed at the edge of the inflammatory infiltration around the implants made from Akpol S and Trevalon was similar, whereas analogous values for the material Superacryl were higher. The conducted comparative in vivo studies permit us to evaluate positively the home-made metacrylate material Akpol S.
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