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W Winkler

Publications and source records attributed to W Winkler.

At least 19 recordsLinked to original sources
PubMed1990

[Long-term effect of courses for repeat alcoholic intoxication in automobile drivers. Studies after 60 months probation].

Authors report on the analysis of long-term effectiveness of rehabilitation programs for multiple drinking-driving offenders. Even after an observation-period of 60 months since license renewal after treatment, program participants show a lower reconviction-rate than drivers who had been judged qualified to drive after medical and psychological assessment. Hence, there is no evidence for a mere deceleration of recidivism but on the contrary for long-term effectiveness. The analysis comprised the influence of individual variables such as age, previous DWI offenses, BAC in the event of DWI, previous criminal offenses, medical symptoms of alcohol-dependence and on the other hand systematic effects such as intensity of law enforcement by the police and regional drinking-habits. Furthermore the effects of three different treatment programs on the long-term reconviction rate are analysed and presented. The study discusses a number of critical arguments with respect to methodology and recommends consequences for future assessment and treatment. On the background of the problems of an extended observation period in the field--changes of variables of influence on drinking and drinking-driving behavior are possible, which cannot be compensated by treatment--the results are judged highly satisfying. They do not only justify continuing treatment after assessment but lead to the recommendation to extend treatment.

Accidents, Traffic↗
PubMed1989

Lactobacillus effects on cholesterol: in vitro and in vivo results.

A double blind investigation was conducted on the influence of a commercially available tablet containing Lactobacillus acidophilus and Lactobacillus bulgaricus (Lactinex Becton Dickinson Microbiology Systems, Cockeysville, MD) on human serum lipoprotein concentrations. Tablets containing about 2 X 10(6) viable bacteria of Lactobacillus mixtures or placebo tablets were ingested by 354 nonfasting informed subjects in a dose of one tablet each, taken four times a day. There was a 3-wk washout period between two 6-wk treatment periods. The number of viable lactobacillus in unused returned tablets was the same at the end of the study as in the beginning. Analysis of paired data using Wilcoxon signed ranks test showed no major effects on lipoprotein concentrations for either the placebo-treated group or the lactobacilli-treated group. There were no statistically significant differences for low density lipoprotein concentrations between the lactobacilli-treated group and the placebo-treated group. The high density lipoprotein concentrations increased 1.8 to 3.0 mg/dl in both groups for both study periods. For total cholesterol the placebo-treated group experienced a statistically significant increase in the first period according to the Wilcoxon signed ranks test (from 208.0 to 215.0 mg/dl, P less than .001) but not according to a two-sample Student t test. Total cholesterol did not change significantly for the Lactobacillus-treated group in either period. Cardiac risk factor (ratio of total cholesterol to high density cholesterol) did not vary during the study. Lipoprotein values increased immediately following vigorous exercise compared with following 15 min of resting without either placebo or treatment. Sample controls for assay and reassay gave virtually identical values (coefficient of variation 1.6%), confirming that assay results were quite reliable. Thus, ingestion of commercially available Lactobacillus tablets, which contain about 2 X 10(6) cfu/tablet of L. acidophilus and L. bulgaricus cells in a dose of four tablets daily did not affect serum lipoprotein concentrations.

Buffers↗
PubMed1986

[Knee orthoses].

Explore the source record for details and available documents.

Arthritis↗
PubMed1983

[Chances, possibilities and effects of new installations, mainly automated protocols in the field of cytology as well as cytologic early cancer diagnosis].

In the recent past symptoms of a reorganization of laboratory medicine became apparent. They were brought about by methodological progress in analytical biochemistry, chemistry and also by the rapidly increasing efficiency of automation in the clinical laboratory as well as in medical practice. A somewhat parallel change also comes into existence in cytology and also, within certain limits, the histology. Since the early seventies the German Government, in accord with these developments, has supported some projects purporting to design better, more reproducible and more simple procedures in clinical diagnosis. With regard to cytological detection of malignancy this meant the development of methods to render cytological diagnosis a more potent tool for the recognition of cancer at an earlier stage on pre-selected material and with a high degree of sensitivity. Requirements on the quality of these methods with regard to reliability and safety will be discussed together with those marginal conditions which are expected to have a bearing on decisions aiming at the introduction of those methods into cytological routine. Consideration of those problems will be based on qualification requirements on prescreening procedures in general and manual cytological prescreening in particular. Discussion will also be extended on procedural sources of error.

Autoanalysis↗