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Biomedical subjects

W Witte

Publications and source records attributed to W Witte.

At least 127 records · Page 7Linked to original sources
PubMed1986

Methicillin-resistant Staphylococcus aureus (MRSA) in the German Democratic Republic. Incidence and strain-characteristics.

In GDR methicillin-resistance strains of S. Aureus only occur in connection with nosocomial infections with a comparably low incidence (about 2%). They are not found in outpatients. For the detection of MRSA the test on nutrient medium L4 with addition of 5% NaCl has proved successful. All of the MRSA exhibit a rather unique pattern of strain-characteristics; they are nontypable by the basic-set-phages and show a reaction with the experimental phage A 994. The MRSA are multiple drug-resistant (generally penicillins, cephalosporins, isoxyzolylpenicillins, oxytetracycline, minocycline, streptomycin, erythromycin, lincomycin and additionally chloramphenicol and gentamycin, kanamycin, tobramycin). The genetical characterization and the plasmid-pattern analysis has shown that only resistance to chloramphenicol and in one case also to macrolides are determined by plasmids (MW 2.0 and 1.8 Megadalton). The determinants for the other resistance-characters are obviously located on the chromosome. Altogether these data indicate that the MRSA described are derivatives of a single-strain-clone.

Cross Infection↗
PubMed1984

Occurrence of a nonplasmid-located determinant for gentamicin resistance in strains of Staphylococcus aureus.

The occurrence of resistance to gentamicin in strains of Staphylococcus aureus with different phage patterns in two hospitals is described. The data suggest transfer of gentamicin resistance between different strains. In the strains investigated the determinant for resistance to gentamicin (parallel resistance to kanamycin and tobramycin) is located on the chromosome. The transfer of this resistance determinant in a mixed culture of donor and recipient cells in vitro is mediated by transduction because it is dependent upon lysogenicity of the donor for a serogroup-B phage and because it can be inhibited by gamma-globulin. The transfer is always associated with lysogenization of the recipient cells by this phage.

Bacteriophage Typing↗
PubMed1983

[Staphylococcus epidermidis as a rare cause of sepsis].

Implanted synthetic materials have to be included into the differential diagnosis of sepsis. This paper reports on a case of sepsis caused by Staphylococcus epidermidis in connection with a Spitz-Holter shunt. The interval between the implantation and the recognition of the endoplastitis took 4 years. The attempt of an antibiotic sanitation had no results. The fitness for work could be restored by removal of the shunt and reimplantation.

Adult↗
PubMed1983

A new semidefined nutrient medium for bacterial susceptibility testing.

A new semidefined nutrient medium for testing of bacterial resistance against chemotherapeutics is described. Nutrients, poor in antagonists, vitamins and ions are balanced. Full effectiveness in view of sensitivity and expression of bacterial resistance mechanisms of all chemotherapeutics tested is guaranteed. The nutrient medium, known under the trade name "Kulturmedium L4 zur Resistenzbestimmung" is comparable with the new recommended international media for this purpose. Beyond it the nutrient medium is useful for genetical investigations and combined with a diagnostic system for selecting different bacteria contained especially resistance properties.

Amino Acids↗