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Biomedical subjects

W Wodrig

Publications and source records attributed to W Wodrig.

At least 19 recordsLinked to original sources
PubMed1995

[Value of serum placental protein 14 determination in differential diagnosis of abnormal early pregnancy].

Single measurements of hCG and placental protein 14 were carried out in 32 patients with tubal pregnancies, in 38 patients with spontaneous abortion and 28 women with normal intrauterine pregnancies from the 5th to the 7th week of pregnancy. HCG-measurement could only show significant differences between normal and abnormal early pregnancies. PP 14-measurements showed significant differences between all groups. Low concentrations of serum PP 14 point to an ectopic pregnancy.

Abortion, Threatened↗
PubMed1994

[The value of serum progesterone and 17-hydroxyprogesterone determination in differential diagnosis of abnormal early pregnancy].

Single measurements of HCG, progesterone and 17-hydroxyprogesterone in blood samples were carried out in 32 patients with tubal pregnancies, in 38 patients with spontaneous abortions and 28 women with normal intrauterine pregnancies from the 5th to the 7th week of pregnancy. Although all 3 parameters showed significant differences between normal and abnormal early pregnancies, no difference between abortions and tubal pregnancies could be shown. The additional measurement of serum-progesterone and 17-hydroxyprogesterone for clinical use can be avoided.

17-alpha-Hydroxyprogesterone↗
PubMed1992

Naloxone stimulation test in women with hypothalamic amenorrhea: a preliminary report.

We researched the possibility of the induction of ovulation by means of chronic opioid receptor blockade in 4 women with hypothalamic amenorrhea. Daily 4 mg naloxone were given as a bolus injection intravenously. By means of continuous determination of LH, FSH, 17-beta-estradiol (E2) and progesterone as well as of sonographic folliculometry follicular growth and subsequent ovulation should have been proved. Neither we found alterations of the basal values of LH, FSH, E2 and progesterone, nor we observed a follicular growth. These results lead us to the conclusion to put a naloxone stimulation test before further therapy. In this way opioid mediated hypothalamic ovarian insufficiencies can be registered and a therapy optimum can be reached early.

Adult↗
PubMed1989

Human early pregnancy factor and early pregnancy associated protein before and after therapeutic abortion in comparison with beta-hCG, estradiol, progesterone and 17-hydroxyprogesterone.

Serum activities and concentrations, respectively, of early pregnancy factor (EPF), early pregnancy associated protein (EPAP), beta-hCG, estradiol, progesterone and 17-hydroxyprogesterone were estimated in 20 healthy primigravidae within the tenth to twelfth completed gestational week before and after therapeutic abortion. EPF, beta-hCG and estradiol markedly decreased after termination of pregnancy, whereas progesterone and 17-hydroxyprogesterone concentrations moderately fell. EPAP showed no significant alterations in a 24 hours period. Because of its possible role as immunosuppressive substance and its short half-life EPF may be a promising immunobiomarker for disturbances in early pregnancy.

17-alpha-Hydroxyprogesterone↗
PubMed1989

Pituitary response in the doubled GnRH-TRH test on the 5th day post partum or post abortum after ablactation by oral means of ethinylestradiol sulfonate.

The function and reactivity of the hypothalamo - anterior pituitary axis had been tested after primary ablactation with ethinylestradiol sulfonate (EES) by means of the doubled GnRH-TRH-test. The reaction of the hypothalamo-pituitary axis is, in early puerperium, drastically reduced by GnRH stimulation. The physiological hyperprolactinemia of puerperium leads to a non-responsiveness by means of exogenous GnRH. Simultaneously there exists a greater sensitivity of the hypothalamo-pituitary system for the negative and a relatively lesser sensitivity for the positive feedback of estrogens in puerperium.

Abortion, Spontaneous↗
PubMed1988

[Release of estrogen-induced positive feedback in the follicular phase].

Influence of estradiol on the secretion of pituitary gonadotropins in a sense of positive feedback in formating not until the progress of development of puberty. Appearance of positive feedback mechanism, which cause the secretion of LH and FSH reason of increasing estrogen doses, induces menstrual cycle. In 10 healthy, normally menstruating women plasma LH and FSH have been measured before and every 12 hours after an intramuscular injection of 50 micrograms estradiol benzoate per kg body weight. A positive feedback could be observed between the 5th and 14th day of the menstrual cycle. At first the LH-concentration decreased and then after 36-48 hours estradiol benzoate injection induced an increase of LH.

Adult↗
PubMed1987

The modulating effect of estrogens on luteinizing hormone release in complete androgen insensitivity syndrome before and after gonadectomy and cyclic steroid application.

The response of LH release to exogenous estrogens was studied in three patients with androgen insensitivity syndrome (AIS) before and after gonadectomy and a prolonged treatment with a sequential pill. Estrogen provocation tests were performed in which 0.05 mg/kg body weight estradiol benzoate was administered intramuscularly and serum FSH and LH levels were assessed every 12 hours for 96 hours after gonadectomy, three months after a prolonged treatment with a sequential pill (16 cycles: 9 days mestranol 100 micrograms, 12 days mestranol 80 micrograms and chlormadinone acetate 2 mg) and in one patient before gonadectomy. The control group consisted of 10 normal females during the follicular phase. A positive feedback effect was induced in normal females and in AIS patients after prolonged treatment with a sequential pill.

Adolescent↗
PubMed1987

[Can changes in the gonadotropin response in androgen insensitivity syndrome be detected with the GnRH test following gonadectomy and steroid administration?].

Information about the reaction of the hypothalamic pituitary axis by Gn-Rh-stimulation dependent from gonadectomy and steroid substitution in 3 patients with androgen insensitivity syndrome. The test was done before and after gonadectomy, under receipt of within the intake of a sequential hormonal contraceptive (Sequenz-Ovosiston) in the 16th cycle and after a pill free interval of 3 months, LH and FSH were estimated with a RIA-method. The LH-base-concentration is independent from the moment of the gonadectomy normogonadotrop and indicate after Gn-Rh-stimulation a regular LH-answer. The FSH-reaction is clearly dependent from the moment of gonadectomy. Not the gonadectomy but the steroid substitution over a long time is decisive about the reaction of the adenohypophysis.

Adolescent↗
PubMed1981

[Circadian variations in insulin concentrations and blood glucose in non-diabetics as well as insulin requirements in insulin-dependent diabetics].

On the basis of the estimation of the plasma glucose and the insulin concentrations in 10-minute intervals during 24 hours by the mathematical analysis (multiple regression) over relations between the behaviour of plasma glucose and insulin concentration insulin secretion rates independent of plasma glucose can be calculated. In non-diabetics a circadian rhythm of the disposal of insulin - independent of food - is established. Thus the secretion rate increases in the early morning hours still before before the first meal and is maintained in different size up to nearly 18 o'clock. Then it established itself to the level of the nocturnal basal rate. Adequate changes of the insulin need during night are proved in diabetics without endogenic residual insulin secretion by means of the artificial B-cell Biostator. The circadian rhythm of the disposal of insulin take place parallel with adequate changes of other biological parameters and is of importance for the practice of the conventional insulin therapy as well as in the future use of non-measuring value-regulated insulin infusions (open-loop system).

Adult↗