Biomedical subjects

W Wolff

Publications and source records attributed to W Wolff.

5 recordsLinked to original sources

PubMed1990

[Epidemiological profile of dental caries and treatment needs].

In a population survey 2,263 patients were examined for their caries status and treatment needs. The DMF/T-Index and the individual relative risk for caries were calculated. Adolescents and young adults showed a high caries risk and required most of all necessary restorations. But especially older adults and seniors over 55 years presented a high caries risk, required more extensive restorations and more public dental health care at all.

Adolescent↗

PubMed1990

Changes in the distribution of proteinpolysaccharide complexes within the articular cartilage in experimental osteoarthrosis.

The quantity and type of proteinpolysaccharide complexes in the matrix determine up to a great extent the mechanical properties of articular cartilage. It is the purpose of this study to evaluate the changes in the mentioned matrix components against the background of experimentally induced osteoarthrosis. As shown by electron microscopic and morphometric studies, the changes in the superficial layer are promptly occurring and clearcut, whereas those in the deep layers are recorded in late observation terms only. A reduction of proteoglycan quantity is noted with a simultaneous differentiation of their fine structure in the various stages of osteoarthrosis development. Initially the alteration in the cell organization of chondroblasts is associated with occurrence of differences in proteoglycan content, and subsequently--in the collagen structures of the matrix too.

Animals↗

PubMed1990

[Estimation of the healing process of denatured orthotopic bone implants in an animal model. I. Measurements with polarization microscopy].

The paper gives in a series of 3 parts a survey, quantitative statements and conclusions on the healing process of denatured orthotopic osteoresections with the initial bone obtained by, polarization optical measurements (this first part), morphological evaluation method (part II), (in these cases the collagen polymorphism served as indicator for the regeneration course) and, semiquantitative method of observation after conventionally histological treatment as well (part III). The investigations were carried out on the mandible of pigs depending on the treatment of the resected bone parts (chemical or hyperthermal denaturation in comparison with the native state). Samples of osteoreimplantions were taken in intervals of one week up to the 70th postoperative day. Histological sections were used from the different regions (contact region, gap region, border and internal regions of the resections) and investigated by the methods mentioned above. The results of the first part (polarization microscopical measurements) revealed the regular course of differentiation in the bone regeneration process: The resection is fully integrated into the initial bone after a mean duration of 112 +/- 25 days. The fastest regeneration takes place in the contact region, the slowest is found within the resection (in the case of chemical denaturation investigated).

Animals↗

PubMed1979

[Synthesis of the fragments A1-8, A1-7, A9-15 and A8-15 of the chicken insulin A chain (author's transl)].

By coupling the peptide derivatives H-Cys(SBut)-Cys(SBut)-His-OMe(6-8 b) and H-Cys(SBut)-Cys(SBut)-OH(6-7b) respectively with Trt-Gly-Ile-Val-Glu(OBut)-Gln-OH(1-5a) the N-terminal sequences A1-8 and A1-7 of the chicken insulin A chain have been prepared. The sequence of A9-15 has been obtained by connecting Bpoc-Asn-Thr(But)-Cys(SBut)-OH (9-11c) and H-Ser(But)-Leu-Try(But)-Gln-OH (12-15). Acylation of the aminopeptidderivative 9-15b with Bpoc-N2H3 yielded fragment A8-15 (8-15).

Animals↗

PubMed1976

Flexible colonoscopy.

Colonoscopy with fiberoptic instruments has opened new vistas in diagnosis and treatment of colonic disease. Such endoscopy requires skill, experience, and judgment to be accomplished readily and safely but permits visual examination of the entire colon and, frequently, the terminal ileum as well. Although in experienced hands colonoscopy may have greater diagnostic accuracy than the barium enema, particularly with respect to colorectal cancer and polyps, the two are complementary modalities and with their combined use an extremely high rate of detection and confirmed diagnosis can be expected. The Beth Israel group introduced the technique of snare-cautery removal of colonic polyps via the colonoscope and has now successfully resected over 2500 such polyps without a single death. This is the largest world experience. Selected polyps can be removed endoscopically as an ambulatory procedure, reducing costs and incapacitation time. Neoplastic polyps often harbor invasive cancer and their extirpation is expected to reduce the incidence of overt colorectal cancer. Colonoscopy and endoscopic polypectomy offers the opportunity to check the rising incidence, morbidity, and mortality related to colorectal cancer.

Adenoma↗