Biomedical subjects

W Wróblewska

Publications and source records attributed to W Wróblewska.

3 recordsLinked to original sources

PubMed2001

Autoimmune hepatitis in the course of chronic HAV--four year observation.

The paper presents a case of a 17-year-old girl with type 1 autoimmune hepatitis in whom biochemical, serological and histopathological markers of chronic hepatitis A were observed for the last 4 years. The diagnosis was based on elevated levels of gammaglobulins, IgG and the presence of autoantibodies (ANA, SMA). At first, the patient was treated with the pulses of corticosteroids and then, as no improvement was observed, continuous steroid therapy was involved. Relatively mild clinical course of the disease and good response to treatment with prednisone were recorded. Our observations suggest that HAV is capable of inducing autoimmune reactions and they indicate possible development of chronic hepatitis A.

Adolescent↗

PubMed2000

[Immunologic disorders in children with Lyme borreliosis].

In this study we present evaluation of some immune parameters in children with borreliosis. We examined subsets of blood lymphocyte (CD3, CD4, CD8, CD19, CD3 HLA DR) and NK cells using monoclonal antibodies and flow cytometry in 14 children age from 3 to 16 years. We observed an altered lymphocyte phenotypes and NK cells in infected children compare to healthy control. We conclude that the changes in host immune response may play an important role in the pathogenesis of borreliosis and their monitoring may be helpful for the prognosis the course of the disease.

Adolescent↗

PubMed1996

[Herpes simplex encephalitis in children].

Clinical course of Herpes Simplex Encephalitis were shown in this paper. 24 children in the age of 4 to 15 were treated at Polish Mother's Memorial Hospital in years 1992-1994. Value of EEG, CT scan, NMR were underlined in early diagnostic and casual treatment of diseases. All children from this analysis group survived, only 8 demonstrated late complications: epileptic attacks (3), spastic tetraparesis (1), encephalopathy and mental disturbances (1). Positive results of treatment were connected with early diagnosis and early antiviral treatment which is very important in decreasing death rate and preventing permanent injury.

Adolescent↗