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Biomedical subjects

W X Chai

Publications and source records attributed to W X Chai.

8 recordsLinked to original sources
PubMed1999

Na+/Ca2+ exchange current in myocytes isolated from rat hypertrophied heart.

Effects of myocardial hypertrophy on the Na+/Ca2+ exchange current in isolated rat cardiac myocytes were investigated, using whole cell patch techniques. Goldblatt 2-kidney, one-clip technique was used to induce cardiomyocyte hypertrophy. The results demonstrated that the Ni(2+)-sensitive Na+/Ca2+ exchange current density was larger in hypertrophied cells than that in normal cells. At a holding potential of mV, the outward current densities were 1.53 +/- 0.31 pA/pF in normal cells and 2.62 +/- 0.53 pA/pF in hypertrophied cells (P < 0.01). At a holding potential of -100 mV, the inward current densities were 0.42 +/- 0.14 pA/pF in normal cells and 1.12 +/- 0.33 pA/pF in hypertrophied cells (P < 0.001). The results suggest that during myocardial hypertrophy the Na+/Ca2+ exchange current is significantly increased.

Animals↗
PubMed1995

Long-term results of fourth ventriculo-cisternostomy in complex versus simplex atresias of the fourth ventricle outlets.

Twelve cases of atresia of the fourth ventricle outlets are presented and they are classified into 2 types: simplex versus complex. Fourth ventriculo-cisternostomy is the treatment of choice. Based on the surgical experiences in simplex cases, new technical modifications were developed to make it applicable to the complex cases as well. The advantages and limitations of such operative approaches over other conventional shunt procedures are compared and the long-term postoperative results are listed. Hopefully, the surgical intervention described here may have opened a reasonable method for treating certain cases of the trapped fourth ventricle as a special variant of the complex atresia type. It is important to realize that knitted tubes are categorically unqualified for the surgical use like this.

Adult↗
PubMed1990

A case of cerebral aspergillosis caused by Aspergillus nidulans. Clinical, pathologic and mycologic identifications.

A case of cerebral aspergillosis is reported, the presenting symptom was numbness of right face, which worsened after one year. CT-scan showed two enhanced low-density patches in the anterior and basal parts of right temporal lobe. During operation, an abscess in the deep part of right temporal lobe was revealed. The patient gradually felt amaurosis and oculomotor palsy of right eye. About six months later, she died from intracranial hypertension. Biopsy, as well as autopsy findings suggested fungal infection, and was identified as Aspergillus nidulans, which has probably never been reported in the literature.

Aspergillosis↗
PubMed1984

Massive osteolysis of the skull: long-term follow-up observations after cranioplasty. Report of two cases.

Two cases of massive osteolysis involving the cranial vault are presented. Unlike disappearing bones in other regions, it is vital to protect the brain from injury by performing cranioplasty once the bone loss has reached a reasonable extent. This appears to be the first report on surgical management in massive osteolysis of the skull. Long term follow-up results are given. The diagnosis and differentiation from related conditions are discussed.

Adult↗