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Biomedical subjects

W X Chen

Publications and source records attributed to W X Chen.

29 records · Page 2Linked to original sources
PubMed1993

[Comparison of anti-inflammatory, analgesic activities, anaphylactogenicity and acute toxicity between bee venom and its peptides].

Bee venom 1.0-2.0 mg/kg and bee venom peptides 1.0-2.0 mg/kg inhibited several inflammatory processes, such as ear swelling induced by xylene in mice, edema produced by injecting 1% carrageenin 0.1 ml beneath the plantar surface of hind paw in rats and showed a marked analgesic action induced by the hot plate and potassium antimony tartrate. Bee venom peptides had a markedly more effective action as compared with bee venom itself. The anaphylactogenicity of bee venom peptides was apparently milder than that of bee venom. The LD50 of bee venom ip in mice and bee venom peptides was 7.4 mg/kg and 7.9 mg/kg respectively.

Allergens↗
PubMed1990

[The alkaloids of Dactylicapnos torulosa (Hook f. et Thomas) Hutchins].

Six ingredients were isolated from the whole plant of Dactylicapnos torulosa (Hook. f. et Thomas.) Hutchins. Four of them were identified by UV, IR, 1HNMR and 13CNMR. One of them is a new compound named zijinlongine(I). The three others are 1-methoxyberberium chloride(II), triethylphenylammonium chloride (III) and isocorydine(IV). II and III were isolated from plants for the first time.

Alkaloids↗
PubMed1990

[Diterpenoid alkaloids from Delphinium kamaonense var. glabrescens].

A new and a known diterpenoid alkaloid have been isolated from the root of Delphinium kamaonense var. glabrescens. The chemical structure of the new alkaloid, named glabredelphine, was established as 2(3)-dehydro-6-demethyl-18-demethoxy-delcosine by IR, MS, 1HNMR and 13CNMR spectral data. The known one was identified as tatsiensine. They were isolated from this plant for the first time.

Aconitine↗
PubMed1990

[Studies on the chemical constituents of Aconitum campylorrhynchum].

Six compounds were isolated from the root of Aconitum campylorrhynchum. One of them is a new alkaloid. It has been elucidated as 8-acetyldolaconine by means of IR,MS, 1H and 13CNMR with DEPT, CH-COSY techniques and on the basis of identification with aconosine by saponification. The other five compounds were identified as dolaconine, aconosine, beta-sitosterol, palmitic acid and p-coumaric acid.

Aconitine↗
PubMed1989

Viral haemorrhagic disease in rabbits: a review.

An acute haemorrhagic disease of rabbits was first reported in a southern province of China in 1984. It subsequently spread rapidly to South China and some parts of North China. The disease is characterized by an acute onset with fever, rapid respiration and sudden death. There is a high morbidity and mortality rate. The pathological changes are consistent with severe generalized circulatory dysfunction (hyperaemia, congestion and haemorrhage), marked degeneration of parenchymatous tissue, pronounced serous-haemorrhagic pneumonia and extensive disruption of reticulo-lymphoid tissue. The disease has been named rabbit viral haemorrhagic disease and it has been suggested that the aetiological agent is a picornavirus. A tissue-derived vaccine has been prepared by homogenizing the liver, lung, spleen and kidney of infected rabbits and inactivating with formaldehyde. This review summarizes the information on the aetiology, and epidemiology and clinical and pathological aspects of this new rabbit disease.

Animals↗
PubMed1989

Experimental induction of pneumonia in mice with Bordetella parapertussis isolated from sheep.

The intranasal inoculation of mice with a suspension of ovine isolates of Bordetella parapertussis killed about 11 per cent of animals (four out of 34) between 2 to 3 days post-inoculation and produced a subacute bronchopneumonia morphologically similar to early lesions of naturally occurring ovine chronic non-progressive pneumonia. Pulmonary lesions characterized by alveolar septal congestion and oedema, focal alveolar haemorrhage and intraalveolar and septal infiltration by neutrophils and macrophages were seen in the early stages. Bronchioles often contained an exudate of macrophages, neutrophils and fibrin and later hyperplasia of perivascular and peribronchiolar lymphoid tissue and fibrosis of the interalveolar septa were evident. Electron microscopy revealed extensive degenerative changes in the alveolar epithelium and alveolar macrophages. Pure cultures of B. parapertussis were consistently recovered from infected lungs from 12 h after inoculation to pid 6. Intact organisms and organisms showing varying degrees of degeneration were found free in alveolar spaces or phagocytosed by alveolar macrophages.

Animals↗
PubMed1989

Saponins from Chinese folk medicine, "zhu jie xiang fu," Anemone raddeana REGEL.

From the Chinese folk medicine "Zhu jie xian fu" (roots of Anemone raddeana REGEL, Ranunculaceae), two new oleanane-type glycosides, named raddeanosides R8 (1) and R9 (2), were isolated. The structures of 1 and 2 were determined as 3-O-alpha-L-rhamnopyranosyl-(1----2)-O-beta-D-glucopyranosyl- (1----2)-alpha-L-arabinopyranosyl oleanolic acid 28-O-alpha-L-rhamnopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----6)-b eta-D- glucopyranoside and 3-O-alpha-L-rhamnopyranosyl-(1----2)-O-beta-D-glucopyranosyl-(1----2)-al pha-L- arabinopyranosyl 27-hydroxyoleanolic acid 28-O-alpha-L-rhamnopyranosyl-(1----4)-O-beta-D-glucopyranosyl-(1----6)-b eta-D- glucopyranoside, respectively.

Drugs, Chinese Herbal↗
PubMed1989

[Studies on the mutagenicity of amrinone and milrinone].

The mutagenicity of domestic new drugs amrinone and milrinone were studied by Ames test, micronucleus test of mouse bone marrow and chromosome aberration assay in CHO cells. The results were as follows: neither amrinone nor milrinone was mutagenic in the Ames test; in chromosome aberration assay, both gave positive results; in mouse micronucleus test, amrinone gave a positive result when mice were exposed to 0.8 LD50 dose, but milrinone gave a negative result. These results suggested that amrinone and milrinone did not induce gene mutation, but amrinone induced chromosome damage both in vitro and in vivo, while the chromosome-damaging activity of milrinone in vitro may be minimized by biodetoxication in vivo.

Amrinone↗
PubMedDate not supplied

Degradation/solubilization of Chinese lignite by Penicillium sp. P6.

Penicillium sp. P6, isolated from coal mine soil at the Qiantong colliery Liaoning Province, Northwest China, can degrade Chinese lignite in 36 h on a plate colony and in 48 h using a 4-day cultured cell-free filtrate. Results of elemental analysis and IR spectrometry indicated that solubilized products exhibited some alterations in comparison to the original lignite. The amount of fulvic acid extracted from the biodegraded lignite was high, and the molecular distribution of the humic acids from biodegraded lignite changed distinctively in comparison to which extracted from the control lignite, possibly due to the depolymerization associated with fungal biodegradation.

Benzopyrans↗