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Biomedical subjects

W de Mello

Publications and source records attributed to W de Mello.

At least 19 recordsLinked to original sources
PubMed1994

[Enalapril reduces the degree of left ventricular remodeling after acute myocardial infarction and reduces the incidence of arrhythmia in ischemic disease].

The present study shows that enalapril prevents the excessive remodeling of the left ventricle after acute myocardial infarction. This randomized and double blind clinical study analysed 50 patients with an inferior myocardial infarction. The effect of enalapril was evaluated through cardiac volumes, ejection fraction, neurohormonal levels and incidence of the left ventricle disfunction after acute myocardial infarction. The patients treated with enalapril showed a significant reduction on the values of nor-epinefrine, angiotensine II, natriuretic hormone and vasopressine, four weeks after initiation of treatment. The ejection fraction and the level of the wall movement was more favourable, four weeks after infarction, in the group treated with enalapril. The incidence of congestive heart failure and arrhythmias was lower in the group treated with enalapril. So, we conclude that enalapril is a drug that prevents the excessive remodelling of the left ventricle after an acute myocardial infarction.

Aged↗
PubMed1990

[Presence of debris in the apical region of dog teeth after biomechanical preparation with or without the use of an auxiliary cream substance].

The subject of this work is to observe if the employment of a cream (ENDO-PTC) during the root canal preparation contributes or not to the condensation of debris in the apical region. Twenty root canals of dogs teeth were divided into two experimental groups: in the first one, the biomechanical preparation was carried out up to the n. 50 Kerr file by using irrigation and aspiration with sodium hypochlorite. In the second experimental group the canal negotiation was done in the same way but using a cream (ENDO-PTC) with sodium hypochlorite as a lubrication substance. A final irrigation and aspiration with sodium hypochlorite was also done in this group. The animal was killed and the pieces prepared for histological analysis. The histological results show us that the employment of a cream during the negotiation of the root canal contributes to a higher condensation of debris in the apical area.

Animals↗
PubMed1990

[Behavior of periapical tissue of dog teeth after canal obturation with Sealapex with or without iodoform].

Some endodontists use iodoform in Sealapex in order to rend it more radiopac. This procedure is empiric and for this reason we decided to observe, histologically, if the iodoform introduces some modification in the biological properties of Sealapex. Thirty root canals of dogs' teeth were overinstrumented and filled, by lateral condensation technique, with gutta percha points and Sealapex, with or without iodoform. The iodoform was added in two different proportions: 30 mg or 112 mg for one centimeter of the base and one centimeter of the catalyst of Sealapex. The pieces were removed for histological studies, 6 months after the treatment. The histological results showed that Sealapex encourages apical closure by cementum deposition and that the addition of iodoform does not change that biological property.

Animals↗
PubMed1984

In vivo fixative effect of formocresol on pulpotomized deciduous teeth of dogs.

Formocresol was checked with respect to its in vivo fixative effect after pulpotomy, through observation of tissue resistance to necrosis. The root pulps were freed from their hard-tissue wrapping and processed for 48 hours, followed or not by capping (15 days) with zinc oxide-eugenol or with zinc oxide-eugenol-formocresol. The effect of only capping with zinc oxide-eugenol, with or without formocresol, was also recorded.

Animals↗
PubMed1980

Tissue reactions following apical plugging of the root canal with infected dentin chips. A histologic study in dogs' teeth.

The object of the present work was to observe whether the condensation of a plug of infected dentin in the apical region, before the filling of a root canal, could show results similar to those found in the absence of contamination. The histologic analysis of the periapical tissues of dogs' teeth containing infected apical plugs showed results that were totally unfavorable, when compared to cases in which the plugs were absent. Such data do not encourage the use of dentin plugs for cases of contaminated root canals, at least until other experiments can better clarify the problem.

Animals↗
PubMed1979

Root canal treatment with calcium hydroxide. I. Effect of overfilling and refilling.

Root canals of dog premolar teeth were negotiated and overfilled with calcium hydroxide paste. After 30 days, half of the treated teeth were refilled up to the apical limit. Root canals not filled were considered as the control group. Ninety days after the first treatment, histologic analysis showed more favorable results in the refilled root canals. The overfilling elicits calcium hydroxide resorption and the ingrowth of periapical connective tissue into the root canal.

Animals↗
PubMed1979

Permeability of the hard tissue bridge formed after pulpotomy with calcium hydroxide: a histologic study.

Analysis of these results shows that complete hard tissue bridges, aside from occurring with great frequency, produce a satisfactory protection to the pulp. In a case in which the barrier is incomplete, some future clinical problems may result as an incomplete barrier does not offer adequate protection as shown by the chronic inflammatory reaction in the remaining pulp tissue.

Animals↗