PubMed Health⌕ Search

Biomedical subjects

W-S Liu

Publications and source records attributed to W-S Liu.

4 recordsLinked to original sources
PubMed2006

Synthesis and crystal structure of some transition metal complexes with a novel bis-Schiff base ligand and their antitumor activities.

Mononuclear complex of Zn(II) with a new bis-Schiff base ligand derived from 2,3-butanedione and thiosemicarbazide, [Zn(II)L.H2O].2DMF [L = (2E,2'E)-2,2'-(butane-2,3-diylidene)bis(hydrazinecarbothioamide)], and other transition metal ions [Cu(II), Mn(II), Co(II), Ni(II)] complexes have been prepared. The Zn(II) complex has been structurally characterized by X-ray crystallography. Among the five complexes, the Cu(II) complex has the novel highest antitumor activity.

Antineoplastic Agents↗
PubMed2005

Characterization and RH mapping of bovine microsatellites generated from a microdissected BTA20-specific DNA library.

Bovine chromosome 20 (BTA20) is associated with several quantitative trait loci (QTL) for meat tenderness, birth weight, milk yield and composition. Fine mapping of these QTL requires the development of additional informative markers to increase the resolution of the BTA20 genetic and physical maps. A BTA20-specific library was constructed by means of microdissection and microcloning, and screened for dinucleotide repeats with (CA)16 and (GT)16 oligos. A total of 60 new microsatellites (MS) were developed and characterized for polymorphism using the U.S. Department of Agriculture (USDA)/Meat Animal Research Center (MARC) bovine reference family, of which 53 markers were informative in this family. The number of alleles for these loci varied from 1 to 14, with an average of 6.5. Thirty-three of these MSs, together with 105 markers previously mapped to BTA20, were scored on a 7000-rad cattle-hamster whole-genome radiation hybrid panel (SUNbRH), resulting in a high-resolution RH7000 rad map for BTA20.

Animals↗
PubMed2003

Bovine Y chromosome microsatellite polymorphisms.

Thirty-eight bovine Y chromosome (BTAY) microsatellites (MS) were assessed for polymorphisms in DNA samples obtained from 17 unrelated bulls. Thirty-three of these microsatellites are new and were used for the construction of a first generation radiation hybrid map for BTAY (Liu et al., 2002). Five MS had been previously reported and were used as positive controls. Fourteen out of 38 MS were found to be polymorphic; the remaining 24 were uninformative among the animals tested. The number of hemizygous loci per MS within individual ranged from two to over 20. Seven MS presented smear- or ladder-like bands, a unique feature for Y chromosome multi-copy hemizygous MS loci. The locus length variance, within individual, ranged from 2 to 42 bp corresponding to the MS with the minimum and maximum number of loci observed, respectively. Within the 14 polymorphic MS, the five pseudoautosomal MS, on average, were more polymorphic (35.3%) than the nine Y-specific MS (19.6%). Haplotypes resulting from combinations of these polymorphic loci will provide a powerful tool for future studies on the origin of domestic cattle and the evolution of bovid species.

Animals↗