Biomedical subjects
Publications and source records attributed to WK Lee.
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Novel poly(ethylene glycol) (PEG) and sulfonated PEG (PEG-SO(3)) acrylate copolymers have been prepared and characterized to apply as coating and blending materials for biomedical applications. The modified surfaces using acrylate copolymers demonstrated increased hydrophilicity, possibly due to the hypothesized reorientation of PEG/PEG-SO(3) chains into water phase. All copolymer surfaces demonstrated less platelet adhesion than control. In addition, platelet adhesion on copolymer surfaces decreased as the chain length of PEG and sulfonated PEG in copolymers increases. All copolymer surfaces reduced bacterial adhesion significantly and the adhesion level differs depending on surfaces as well as media. The obtained results attest to the usefulness of these copolymers as a coating or additive material to improve the blood compatibility of blood contacting devices.
We have created a one- (rather than two-) dimensional quasi-steady-state photorefractive spatial soliton induced by a laser beam instead of an applied electric field. The formation of this type of spatial soliton depends on the intensity of the self-trapped beam, which is different from quasi-steady-state spatial solitons reported in the literature. The optically induced spatial soliton can be exploited in all optical switching applications.
A kinetic model for single component protein adsorption which can be readily extended to adsorption from multi-protein solutions was developed, and used to simulate adsorption of site-directed, structural stability mutants of bacteriophage T4 lysozyme. The model allows for two different adsorbed "states," distinguished by different binding strengths and different occupied areas. The presence of an increasing energy barrier to adsorption was incorporated into the model by formulating the adsorption rate constants as functions of time. Numerical analysis was performed using the Marquardt method. Estimated model parameters were consistent with the effect of structural stability on adsorption. In particular, kinetic parameters were such that adsorption into the more tightly bound, conformationally altered state was favored by less stable variants. Copyright 1999 Academic Press.
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