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Biomedical subjects

Walter R Shelton

Publications and source records attributed to Walter R Shelton.

4 recordsLinked to original sources
PubMed2005

Indications for allografts.

Allografts continue to be popular in orthopaedic reconstruction procedures of the knee. Approximately 1 million musculoskeletal allografts were distributed in the United States in 2004 alone. Ligament allografts, osteochondral allografts, and meniscal transplants have all demonstrated success in knee reconstructions. The advantages of allograft tissue include the lack of donor site morbidity, shorter operative times, ease of sizing, and a lack of clinically significant immunologic reactions. These advantages should be weighed against the risk for disease transmission, increased cost, and increased time of graft incorporation. Throughout the consent process, comprehensive patient education is imperative to assist in this important decision.

Arthroplasty↗
PubMed2002

Evaluation of small-intestinal submucosa implants for repair of meniscal defects in dogs.

OBJECTIVE: To assess the effects of porcine small intestinal submucosa (SIS) implants on the healing of meniscal lesions in dogs. ANIMALS: 16 adult Greyhounds of both sexes. PROCEDURE: Unilateral osteotomy was performed at time 0 to disrupt the medial collateral ligament attachment, and two (1 cranial and 1 caudal) 4-mm circular defects were created in the avascular portion of the medial meniscus. One defect was filled with an SIS graft, and the other defect remained empty (control). Three months later, the identical procedure was performed on the contralateral limb. Three months after the second surgery, dogs were euthanatized, and meniscal tissue specimens from both stifle joints were collected for gross, histologic, biomechanical, and biochemical evaluations. RESULTS: Regenerative tissue was evident in 4 (2 SIS-implanted and 2 control) of 16 defects examined histologically. In 3 defects, this thin bridge of tissue was composed of immature haphazardly arranged fibrous connective tissue with a relatively uniform distribution of fibroblasts. Aggregate modulus, Poisson ratio, permeability, and shear modulus were not significantly different between control and SIS-implanted defects either 3 or 6 months after surgery. Hydroxyproline content also did not differ between SIS-implanted and control defects at 3 or 6 months. CONCLUSIONS AND CLINICAL RELEVANCE: Implantation of porcine SIS into experimentally induced meniscal lesions in dogs did not promote tissue regeneration.

Animals↗