Biomedical subjects

Weimin Xie

Publications and source records attributed to Weimin Xie.

7 recordsLinked to original sources

PubMed2006

Estrogen receptor alpha polymorphisms associated with susceptibility to hepatocellular carcinoma in hepatitis B virus carriers.

BACKGROUND & AIMS: Overexpression of estrogen receptors (ESRs) is implicated in the development of hepatocellular carcinoma (HCC) in both animal models and humans. We examined whether the ESR1 polymorphisms were related to HCC risk among chronic hepatitis B virus carriers. METHODS: Six ESR1 polymorphisms, which are (TA)n repeat in the promoter, T29C at codon 10 in exon 1, PvuII and XbaI site in intron 1, C136474G at codon 325 in exon 4, and A252966G in intron 5, were genotyped in 248 patients with HCC and 239 controls. The associations with the susceptibility to HCC were estimated by logistic regression. Allele-specific transcription difference of ESR1 messenger RNA was performed by real-time quantitative polymerase chain reaction. RESULTS: We observed a statistically significant increased susceptibility to HCC associated with the homozygous alleles with a high number of TA repeats (assigned as H/H genotype; odds ratio [OR], 2.66; 95% confidence interval [CI], 1.44-4.94; P = .0018), T29C C/C genotype (OR, 2.31; 95% CI, 1.25-4.26; P = .0076), and PvuII C/C genotype (OR, 2.19; 95% CI, 1.27-3.78; P = .0048) compared with the homozygous alleles with a low number of TA repeats (assigned as L/L genotype), T29C T/T, and PvuII T/T genotype, respectively. In accordance, the relative messenger RNA levels of the at-risk C allele of T29C were consistently higher than those of the T allele in heterozygous cells. CONCLUSIONS: Our findings suggest that the genetic polymorphism in ESR1 may play a role in mediating susceptibility to HCC in Chinese hepatitis B virus carriers.

Adult↗

PubMed2006

Association of CYP1A2 genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a high-risk region of China.

OBJECTIVES: Aflatoxin B1 exposure is one of the major risk factors for hepatocellular carcinoma (HCC). CYP1A2 is a cytochrome P450 isoenzyme that plays an important role in the bioactivation of AFB1 to its carcinogenic metabolite. The study was designed to assess whether genetic polymorphisms in CYP1A2 are associated with HCC susceptibility in a high-risk region. METHODS: A case-control study of 431 HCC cases and 550 cancer-free controls recruited from an HCC endemic region in China was carried out. Three single nucleotide polymorphisms, namely -3860G > A (CYP1A2*1C), -3113G > A, and 5347T > C (CYP1A2*1B) were genotyped by polymerase chain reaction-restriction fragment length polymorphism methods. RESULTS: Homozygous carriers of the major haplotype -3860G/-3113G/5347C were associated with increased HCC susceptibility in the overall population (odds ratio [OR] = 1.65, 95% confidence interval [CI]: 1.11-2.46, P = 0.014), in HBsAg seronegative individuals (OR = 2.69, 95% CI: 1.43-5.06, P = 0.002), and in heavy smokers (OR = 2.14, 95% CI: 1.21-3.80, P=0.009). In addition, individuals carrying at least one CYP1A2*1C allele showed significantly decreased HCC risk (OR = 0.49, 95% CI: Q0.27-0.86, P = 0.013) in the HBsAg seronegative subpopulation. Furthermore, as compared with HBsAg seropositive patients, wild-type homozygotes of the CYP1A2*1C polymorphism were significantly over-represented in HBsAg seronegative patients (P = 0.024). No significant association between CYP1A2 genetic polymorphisms and HCC risk was observed in either HBsAg seropositive individuals or non-smokers. CONCLUSIONS: CYP1A2 genetic polymorphisms are associated with HCC susceptibility in smokers and HBsAg seronegative individuals in the Fusui endemic region.

Adult↗

PubMed2004

Basic study on anaerobic biological filtration using a floating filter media.

An experiment of anaerobic filtration using a floating media was carried out in this study. In the present system, a bench-scale column of 50 mm in diameter and of 1500 mm in height and a floating media consisting of S-shaped polystyrene pieces were employed. The purpose of this study was to collect the basic data of anaerobic biological filtration using a floating media. Under the laboratory conditions, it was found that the start-up of an anaerobic biological filter took about half month at 20 degrees C and a lower BOD loading was favorable for this start-up. The BOD removal efficiency over 60% could be achieved at a BOD volumetric loading of the filter bed under 6 kg/m3/d. An effluent BOD concentration became high when the flow rate was high, especially with circulation of treated water, which afforded a large effect on an effluent BOD concentration. As for the mechanism of BOD removal by anaerobic filtration, it was evident that long retention time worked in favor for organic acid generation, and the circulation of treated water promoted decomposition of organic acids.

Bacteria, Anaerobic↗

PubMed2004

[Endoscopic transnasal approach in surgical treatment of ethmoid sphenoid diseases].

OBJECTIVE: To study the surgical experience of endoscopic sinus surgery for the patients with sphenoid sinus disease. METHOD: Twenty-one patients of sphenoid sinus diseases were treated with endoscopy by nasal cavity and sphenoid sinus. RESULT: During 3 months to four years following up, 20 patients were free from disease postoperatively, 1 patient underwent reoperation because of recurrence. CONCLUSION: Nasal endoscope provide the clear visual field, and operation under nasal endoscope could less pain and minimize injury to normal tissue. Transnasal-sphenoidal endoscopic sinus surgery under local anesthesia seems to be a safe and valuable way.

Adolescent↗

PubMed2003

[The treatment of odor containing hydrogen sulfide released in the wastewater of pharmaceutical factory by high efficient bio-reactor with the packed stuffing].

The removal experiment of odor containing hydrogen sulfide(H2S) from sewage disposal plant of pharmaceutical factory was carried out continuously by biological deodorization reactor packed with ZX01 stuffing. The results suggested that removal efficiency of hydrogen sulfide was nearly 100% and metabolism products of H2S was mainly composed of SO4(2-), when the maximum influent load of the bio-reactor was 204 g/(m3.h). When effluent wastewater from second setting pit was used as spray water which containing a small quantity of nitrogen, phosphorus and other elements, the optimum volume of spray water was 3.56 L/(L.d). The bio-reactor had stronger ability to resist shock of high concentration load. The bio-reactor was not blocked during experiment of six months in which resistance was maintained at lower value, therefore, the bio-reactor need not carry out a back washing frequently, and it can be operated steadily for long-term.

Bioreactors↗

PubMed2002

Effects of anaerobic/aerobic incubation and storage temperature on preservation and deodorization of kitchen garbage.

To develop a garbage recycling system for the purpose of the production of lactic acid (LA) to use as raw material for producing biodegradable plastics, the preservation and deodorization of garbage during storage are very important. Anaerobic incubation (i.e., storage) was prove to be more suitable than aerobic incubation during the garbage storage in terms of concentration of LA and soluble sugar, pH value, viable bacteria counts and offensive odour substances. This difference is due to a fact that the growth of putrefactive bacteria such as coliforms and Clostridium spp. appeared to be inhibited by anaerobic fermentation during the storage, because the fermentation caused a drop of garbage pH and generated inhibitory substances, i.e., bacteriocins. Under anaerobic condition, LA concentration in the stored garbage was found to be higher in the order: 37 > 25 > 50 > 5 degrees C, and the concentration of sugar accumulated during the 50 degrees C-storage was the highest. Among the conditions employed, the optimum condition for the storage of kitchen garbage was anaerobic at 5 degrees C.

Bacteria, Aerobic↗

PubMed2002

[Diagnosis of foreign bodies in trachea and bronchus of children by means of coronal CT scan].

OBJECTIVE: To study the sensitivity, specificity and clinical value of coranal CT scan of trachea and bronchus in diagnoing children's foreign body in bronchus. METHOD: 30 cases of the children with foreign body in their trachea and bronchus were examined by chest X ray (chest X-ray), and by coranal CT scan at the same time. (some of them were compared with axial CT scan.) RESULT: The position of foreign body in trachea and bronchus was definitely diagnosed by coronal CT scan in all cases, of whom, 28 cases with obstructive emphysema; 5 case with obstructive pneumonia and 3 cases with obstructive atelectasis. CONCLUSION: Coranal CT scan could demonstrate the position of foreign body in trachea and bronchus and be helpful in planning surgery.

Bronchi↗