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Weiwu Deng

Publications and source records attributed to Weiwu Deng.

4 recordsLinked to original sources
PubMed2003

The role of CTLA4-Ig in a mouse model against allergic asthma.

OBJECTIVE: To investigate CTLA4-Ig's potential role in therapy for allergic asthma by blocking B7/CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig). METHODS: We divided BALB/C mice into the three groups: Sham/Sham (control), ovalbumin (OVA)/OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology and determination of cytokines were performed 24 hours after airway challenge. RESULTS: In the OVA/OVA group, the number of cells, the percentage of inflamed cells and the level of IL-4 in BALF were increased. Airways in our murine model for allergic asthma underwent pathological changes, which were significantly reduced after treatment with mCTLA4-Ig. CONCLUSION: Blockage of co-stimulation with mCTLA4-Ig can inhibit allergy-specific response of T cells, and asthmatic response as well.

Abatacept↗
PubMed2002

[Restricted usage of repertoire of T-cell receptor V beta in Chinese asthmatics].

OBJECTIVE: To investigate the association of restricted usage of repertoire of T cell receptor V beta (TCR V beta) with asthma. METHODS: In 36 Chinese asthmatics, peripheral blood TCR V beta was studied by means of fluorescein-labeled RT-PCR as well as genescan and genotype software analysis. The clonality of the predominant usage T cell receptors was analyzed by denaturing gel electrophoresis and single strand conformation polymorphism (SSCP) by using genescan analysis (with 377 ABI DNA sequencer). RESULTS: The number of cases predominantly using TCRV beta 8 gene families in asthmatics and those allergy to house dust mite (HDM) was significantly higher than that of normal controls (P = 0.0230, 0.0147), and so the TCR V beta 5.1 gene family for asthmatics allergic to HDM (P = 0.0186). It is remarkable-that only two cases in 36 asthmatics were allergic to ragweed and both of them predominantly used TCR V beta 1 gene families. The TCR V beta gene families predominantly used in asthmatics showed polyclonal expression in all normal controls and most asthmatics, but 5 asthmatics showed oligoclonal expression of TCR V beta 8 gene families. CONCLUSIONS: TCRV beta 8 and TCR V beta 5.1 gene families may be associated with allergy to HDM in asthmatics. TCR V beta gene families in asthmatic peripheral blood showed oligoclonal expression tendency.

Adolescent↗
PubMed2002

Diagnosis of interstitial lung disease in patients with connective tissue disease by the diffusing capacity of carbon monoxide.

OBJECTIVE: To evaluate the value of diffusing capacity of carbon monoxide (CO) as a sensitive and effective test for the diagnosis of early interstitial lung disease (ILD) associated with connective tissue disease (CTD). METHODS: Ninety-three patients with CTD, which included 48 patients with systemic lupus erythematosus (SLE), 18 patients with dermatomyositis (DM), 21 patients with progressive systemic sclerosis (PSS), and 6 patients with sjogren's syndrome (SS), were studied by chest radiography, HRCT and diffusion capacity of carbon monoxide. Fifty healthy individuals were included as the control group. RESULTS: Seven of the 48 (15%) patients with SLE, 3 of the 18 (17%) with DM, 8 of the 21 (38%) with PSS, and 2 of the 6 (33%) with SS were found to have ILD by chest radiography. HRCT abnormalities for ILD were noted in 5/14 (36%) of the patients with SLE, 4/11 (36%) with DM, 5/12 (42%) with PSS, and 2/3 (67%) with SS. Alternation in D(L)CO was present in 20 (42%) patients with SLE, 7 (39%) with DM, 11 (52%) with PSS and 3 (50%) with SS. The means of D(L)CO were (81 +/- 26)% in SLE, (79 +/- 19)% in DM, (76 +/- 25)% in PSS and (76 +/- 11)% in SS, which were significantly different from that in the healthy controls [D(L)CO = (103 +/- 9)%] (P < 0.01). CONCLUSIONS: For the diagnosis of ILD in CTD, chest radiography was less sensitive than HRCT and D(L)CO. D(L)CO, which is highly sensitive, without radioactivity and favorably accepted by patients, may be considered as the method of choice in the early diagnosis of ILD in patients with CTD.

Carbon Monoxide↗