Biomedical subjects

Wen-Liang Hwang

Publications and source records attributed to Wen-Liang Hwang.

3 recordsLinked to original sources

PubMed2006

Gridding spot centers of smoothly distorted microarray images.

We use an optimization technique to accurately locate a distorted grid structure in a microarray image. By assuming that spot centers deviate smoothly from a checkerboard grid structure, we show that the process of gridding spot centers can be formulated as a constrained optimization problem. The constraint is equal to the variations of the transform parameter. We demonstrate the accuracy of our algorithm on two sets of microarray images. One set consists of some images from the Stanford Microarray Database; we compare our centers with those annotated in the Database. The other set consists of oligonucleotide images, and we compare our results with those obtained by GenePix Pro 5.0. Our experiments were performed completely automatically.

Algorithms↗

PubMed2006

Planar-shape prototype generation using a tree-based random greedy algorithm.

A prototype is representative of a set of similar objects. This paper proposes an approach that formulates the problem of prototype generation as finding the mean from a given set of objects, where the prototype solution must satisfy certain constraints. These constraints describe the important perceptual features of the sample shapes that the proposed prototype must retain. The contour prototype generated from a set of planar objects was used as an example of the approach, and the corners were used as the perceptual features to be preserved in the proposed prototype shape. However, finding a prototype solution for more than two contours is computationally intractable. A tree-based approach is therefore proposed in which an efficient greedy random algorithm is used to obtain a good approximation of the proposed prototype and analyze the expected complexity of the algorithm. The proposed prototype-generation process for hand-drawn patterns is described and discussed in this paper.

Algorithms↗

PubMed2004

Analysis on multiresolution mosaic images.

Image mosaicing is the act of combining two or more images and is used in many applications in computer vision, image processing, and computer graphics. It aims to combine images such that no obstructive boundaries exist around overlapped regions and to create a mosaic image that exhibits as little distortion as possible from the original images. In the proposed technique, the to-be-combined images are first projected into wavelet subspaces. The images projected into the same wavelet space are then blended. Our blending function is derived from an energy minimization model which balances the smoothness around the overlapped region and the fidelity of the blended image to the original images. Experiment results and subjective comparison with other methods are given.

Algorithms↗