PubMed Health⌕ Search

Biomedical subjects

Wen-bin Yu

Publications and source records attributed to Wen-bin Yu.

2 recordsLinked to original sources
PubMed2005

[A new type of active noise cancellation earmuffs].

OBJECTIVE: To develop a new type of feedback active noise cancellation earmuff (ANCE) for aviator's helmet. METHOD: A mathematical model of such a structure was established based on frequency response function and automatic control theory. The method and role for designing ANCE controllers were summarized and the optimum design method was used for designing the controllers. RESULT: The acoustic components and simulation circuit were well matched. One of the prototype can attenuate the noise more than 15 dB in the frequency range of 50-2000 Hz (19 dB at the highest). CONCLUSION: The noise cancellation value of this earmuff has achieved international level and it can be mass-produced.

Aerospace Medicine↗
PubMed2004

[Study on isoniazid-resistant Mycobacterium tuberculosis isolates by multiple-polymerase chain reaction-single strand conformation polymorphism].

OBJECTIVE: To develop a new multiple-polymerase chain reaction-single strand conformation polymorphism (multi-PCR-SSCP) system for detecting the aphC promoter, inhA, and katG gene mutations in isoniazid-resistant Mycobacterium tuberculosis isolates in the single reaction, and for the quick diagnosis of isoniazid-resistant Mycobacterium tuberculosis isolates. METHODS: Three pairs of oligonucleotide primers were designed according to the aphC promoter, inhA, and katG genes of Mycobacterium tuberculosis to examine isoniazid-resistance by multi-PCR-SSCP. RESULTS: Isoniazid-sensitivity and resistance were analyzed with general PCR and multi-PCR at the same time, and H(37) Rv was used as a control. These two protocols amplified the anticipated fragments, the rate of consistency being 100%. By single gene PCR-SSCP, the mutation rates of aphC promoter, inhA, and katG gene were 17%, 20%, and 66%, respectively. The mutation rate detected by multi-PCR-SSCP was 83%. CONCLUSIONS: Multi-PCR-SSCP is a sensitive and specific method for rapid detection of aphC promoter, inhA, and katG gene mutations in isoniazid-resistant Mycobacterium tuberculosis isolates. Drug-resistant gene detection may be clinically useful in the therapy of tuberculosis.

Antitubercular Agents↗