Biomedical subjects

Wendell A Lim

Publications and source records attributed to Wendell A Lim.

20 records · Page 2Linked to original sources

PubMed2002

How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2.

Signal transduction proteins that can integrate multiple upstream signals play a critical role in the complex regulatory circuits that control cellular behavior. The two signaling node proteins cyclin-dependent kinase 2 and the actin regulator neuronal Wiskott-Aldrich syndrome protein have qualitatively similar signaling properties. Recent studies, however, reveal that these proteins utilize distinct mechanisms of signal integration, leading to subtle but important quantitative differences in behavior.

Animals↗

PubMed2002

The modular logic of signaling proteins: building allosteric switches from simple binding domains.

Many eukaryotic signal transduction proteins have component-based architectures: they are built from combinations of protein interaction domains and catalytic domains. Intact, these proteins display the sophisticated allosteric behavior required for cellular regulation; the protein's output activity is tightly repressed under basal conditions, but can be robustly activated by a specific set of input effector ligands. A combination of structural, biophysical and computational studies is beginning to shed light on the fundamental principles governing this type of modular allostery.

Allosteric Regulation↗