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Biomedical subjects

Wendy Brown

Publications and source records attributed to Wendy Brown.

At least 19 recordsLinked to original sources
PubMed2006

Walking towards health in a university community: a feasibility study.

OBJECTIVE: Using a randomised control trial design, this study assessed the impact of two walking interventions, on the work day step counts and health of UK academic and administrative, university employees. METHOD: A convenience sample of 58 women (age 42+/-10 years) and 6 men (age 40+/-11 years) completed baseline and intervention measures for step counts, % body fat, waist circumference and systolic/diastolic blood pressure, during a ten-week period (October to December, 2005). Before intervention, baseline step counts (five working days) were used to randomly allocate participants to a control (maintain normal behaviour, n=22) and two treatment groups ("walking routes", n=21; "walking in tasks", n=21). Intervention effects were evaluated by calculating differences between pre-intervention and intervention data. A one-way ANOVA analysed significant differences between groups. RESULTS: A significant intervention effect (p<0.002) was found for step counts, with mean differences indicating a decrease in steps for the control group (-767 steps/day) and increases in the "walking routes" (+926 steps/day) and "walking in tasks" (+997 steps/day) groups. Small, non-significant changes were found in % body fat, waist circumference and blood pressure. CONCLUSIONS: Findings have implications for work-based physical activity promotion and the development of walking interventions within the completion of work-based tasks.

Adult↗
PubMed2006

Dissemination of a community-based physical activity project: the case of 10,000 steps.

This paper describes the use of a web-site for the dissemination of the community-based '10,000 steps' program which was originally developed and evaluated in Rockhampton, Queensland in 2001-2003. The website provides information and interactive activities for individuals, and promotes resources and programs for health promotion professionals. The dissemination activity was assessed in terms of program adoption and implementation. In a 2-year period (May 2004-March 2006) more than 18,000 people registered as users of the web-site (logging more than 8.5 billion steps) and almost 100 workplaces and 13 communities implemented aspects of the 10,000 steps program. These data support the use of the internet as an effective means of disseminating ideas and resources beyond the geographical borders of the original project. Following this preliminary dissemination, there remains a need for the systematic study of different dissemination strategies, so that evidence-based physical activity programs can be translated into more widespread public health practice.

Adolescent↗
PubMed2006

Management of obesity--the role of surgery.

BACKGROUND: Obesity is rapidly becoming Australia's biggest health care issue. OBJECTIVE: This article discusses the role of surgery, in particular laparascopic adjustable gastric banding, in the management of obesity. DISCUSSION: The acceptability and uptake of surgery as a solution to obesity has, in the past, been low. This is largely due to the risks of bypass and stapling procedures, as well as the lack of long term efficacy. Laparoscopic adjustable gastric banding has, over the past 13 years, proven not only to be safe, but effective both in terms of weight loss and control of the comorbidities associated with obesity. It is currently the most effective solution we have available for patients who suffer from obesity.

Bariatric Surgery↗
PubMed2006

Can social marketing approaches change community attitudes towards leprosy?

This essay explores how the concept of social marketing can be employed to change attitudes towards leprosy. Firstly, the concept of social marketing is discussed, then the attitudes that people have about leprosy, the stigma that people with leprosy and their families may face, and the detrimental effects that this can have on their lives. The effect of knowledge and education on attitudes towards leprosy is discussed, as this can be a key component of social marketing campaigns. Various methods of social marketing used to change attitudes and reduce stigma are examined, such as mass media campaigns, school based education, methods which involve community leaders, and the integration and improvement of leprosy services. Principles of social marketing which can lead to the success of campaigns such as incorporating local beliefs are emphasized. The success of the social marketing campaign in Sri Lanka is described, which aimed to remove the fear of leprosy, and to encourage patients to seek and comply with treatment. Finally, it is argued that social marketing, used correctly, can be highly effective at changing community attitudes towards leprosy, reducing stigma and improving the lives of patients, who become able to seek treatment sooner as they lose their fear of stigmatization.

Attitude to Health↗
PubMed2004

Comparison of surveys used to measure physical activity.

OBJECTIVE: To compare the level of agreement in results obtained from four physical activity (PA) measurement instruments that are in use in Australia and around the world. METHODS: 1,280 randomly selected participants answered two sets of PA questions by telephone. 428 answered the Active Australia (AA) and National Health Surveys, 427 answered the AA and CDC Behavioural Risk Factor Surveillance System surveys (BRFSS), and 425 answered the AA survey and the short International Physical Activity Questionnaire (IPAQ). RESULTS: Among the three pairs of survey items, the difference in mean total PA time was lowest when the AA and NHS items were asked (difference=24) (SE:17) minutes, compared with 144 (SE:21) mins for AA/BRFSS and 406 (SE:27) mins for AA/IPAQ). Correspondingly, prevalence estimates for 'sufficiently active' were similar for AA and NHS (56% and 55% respectively), but about 10% higher when BRFSS data were used, and about 26% higher when the IPAQ items were used, compared with estimates from the AA survey. CONCLUSIONS: The findings clearly demonstrate that there are large differences in reported PA times and hence in prevalence estimates of 'sufficient activity' from these four measures. IMPLICATIONS: It is important to consistently use the same survey for population monitoring purposes. As the AA survey has now been used three times in national surveys, its continued use for population surveys is recommended so that trend data over a longer period of time can be established.

Data Collection↗
PubMed2004

Development and preliminary psychometric properties of the multidimensional neglectful behavior scale-child report.

This article describes the development and psychometric properties of the Multidimensional Neglectful Behavior Scale-Child Report (MNBS-CR). The measure is broadly conceptualized to tap child neglect across four core domains: cognitive, emotional, physical and supervisory neglect, and it assesses exposure to violence, alcohol-related neglect, abandonment, and children's appraisals of parenting. Features include pictorial items, audio computer-assisted testing, and programming by age and gender of the child and caregiver. A clinical sample of 144 children, age 6 to 15 years, and a comparison sample of 87 children were tested. Results showed that the MNBS-CR has high reliability, with higher reliability found for older children (alpha = .94) than for younger children (alpha = .66). Among older children, the MNBS-CR Supervisory scale was significantly associated with the Child Behavior Check List (CBCL), and total MNBS-CR scores were significantly associated with clinician reports of behavioral disorders. Younger and older neglected children scored significantly higher on the MNBS-CR than community children.

Adolescent↗
PubMed2004

Parent management training and Asperger syndrome: a randomized controlled trial to evaluate a parent based intervention.

This controlled trial of a parent management intervention aimed to increase parental competence in management of problem behaviours associated with Asperger syndrome. The intervention compared two formats, a 1 day workshop and six individual sessions. Measures were taken on three occasions: pre-intervention, at 4 weeks, and at 3 month follow-up. Variables of interest were number and intensity of problem behaviours, and parent evaluation of social interaction skills. Results showed parents reporting fewer and lower intensity of problem behaviours and increased social interactions at 4 weeks and 3 months. Results held across formats and suggest that parent management training can provide an effective intervention for parents of a child with Asperger syndrome. Group differences on outcome measures and in the use of strategies are discussed along with limitations of the study.

Adult↗
PubMed2004

Steps and sitting in a working population.

This study aimed to assess sitting time and number of steps taken each day, and the relationships between these variables, in a sample of working Australian adults. Workers (N = 185) wore a pedometer for 7 days and recorded the number of steps taken and time spent sitting each day. Average time spent sitting on weekdays was 9.4 (SD = 2.40) hr, with about half spent sitting at work. Despite this, the average steps taken each day (M = 8,873, SD = 2,757) was higher on weekdays than on weekend days. There was a clear inverse relationship between sitting time at work and number of steps taken on weekdays, r = -.34, p < .001); those in the highest tertile for sitting time reported about 3,000 fewer daily steps. Workers in managerial and professional occupations reported more time sitting at work (M = 6.2 hr per day) and lower weekday step counts (M = 7,883, N = 43) than technical (M = 3.3 hr sitting at work and 10,731 weekday steps, N = 33) and blue collar workers (M = 1.6 hours sitting and 11,784 steps, N = 11). The findings suggest those whose daily work involves long hours of sitting should be the focus of efforts to promote physical activity both within and outside the workplace.

Adolescent↗
PubMed2004

Performance characteristics of the Coulter LH 500 hematology analyzer.

The challenge for modern hematology laboratories is to provide accurate and reproducible results, with seamless performance between facilities, in a cost-effective manner. Beckman Coulter recently developed the Coulter LH 500 to meet the needs of smaller laboratories or serve as a backup in larger laboratories. The principal goal of this study was to validate all parameters and performance specifications of the LH 500 compared to the Coulter LH 750 predicate analyzer. A total of 245 spent clinical samples from the London Health Sciences Centre (LHSC) and 251 from the University of Pittsburgh Medical Center Health System (UPMCHS) were analyzed during the study. The samples were selected to include 75% abnormal and 25% normal blood samples. According to the results of a rank sum test, there was no significant difference between the LH 500 and LH 750 for all complete blood count parameters (P > .05) except the red cell distribution width, which showed a slight negative bias on the LH 500. Differential parameters comparing the LH 500 to a 400-cell manual differential showed correlation coefficients (r2) from 0.75 to 0.99 for all parameters except basophils. Of the samples run on the LH 500 at LHSC, the false-positive differential flagging rate was 17.32% and the false-negative rate was 3.03%. Sensitivity was 82.93%, specificity 78.95%, and efficiency 79.65%. At UPMCHS, the false-positive differential flagging rate was 13.37% and false-negative rate 2.97%. Sensitivity was 91.89%, specificity 78.91%, and efficiency 83.66%. Overall, the LH 500 performed accurately and reproducibly compared to the LH 750 and the reference procedures. It would be an excellent second instrument for larger laboratories concerned with harmonization of instrumentation and reagents or as a primary instrument for smaller hematology laboratories with limited space.

Blood Cell Count↗
PubMed2003

Larval cannibalism, time constraints, and adult fitness in caddisflies that inhabit temporary wetlands.

The fitness of non-feeding adult insects depends on energy accumulated during the larval stage. Larvae of the caddisfly Asynarchus nigriculus primarily feed on plant detritus, but supplement their diet with animal material obtained through cannibalism. Habitat drying constrains development in many populations of this species, and we hypothesized that cannibalism should accelerate development to facilitate timely metamorphosis. We manipulated larval diets in a field experiment by supplementing detritus with animal material, and in a laboratory experiment by varying animal material and detritus quality (conditioned vs unconditioned). We measured the effects of dietary manipulation on larval and pupal growth and development, the timing of metamorphosis, and adult fitness correlates. The results of the laboratory experiment suggest that this species can metamorphose with a detritus-only diet, but development is extremely protracted. In the field experiment, individuals with animal material in their diet had higher larval survival, shorter larval and pupal development times, and earlier emergence dates (7-10 days), than those without a supplement. This delay in emergence should have important effects on survival in natural populations where the difference between desiccation and successful emergence can be only a few days. Dietary supplementation also affected adult body mass (30-40% increase), female fecundity (30% more eggs), and proportional allocation to different adult body parts. Our results are consistent with recent growth-development models that predict coupled (earlier emergence and larger adults) rather than tradeoff responses (earlier emergence and smaller adults) to pre-threshold manipulation of larval diets. Many detritivorous aquatic insects supplement their diets with animal material, and our data provide evidence that this supplementation can have strong effects on fitness. This type of dietary supplementation should be especially important for taxa that do not feed as adults, and in temporary habitats that impose time constraints on larval development.

Animals↗
PubMed2003

Variability in response assessment in solid tumors: effect of number of lesions chosen for measurement.

PURPOSE: This study was performed to systematically evaluate the variability in tumor response assessments that occurs depending on how many tumor deposits are selected for measurement at imaging. EXPERIMENTAL DESIGN: The two largest perpendicular diameters of all tumor deposits in 36 patients were measured on computed tomography scans obtained at baseline and first posttherapy follow-up. A computerized modeling analysis of those data was performed to determine each patient's therapeutic response category assignment for every possible number of lesions in a grouping. The variance in the sum of measurements of these lesion groupings was calculated, and the frequency of response assessment categories was plotted against the number of lesions. RESULTS: The computerized analysis of the resultant 1,833,821 possible combinations of tumor deposits showed that when six lesions were measured bidimensionally and four lesions were measured undimensionally, the average variance decreased by 90%. The number of different response assessment categories into which a patient was assigned decreased with increasing lesion grouping size. When six or more lesions were measured bidimensionally, 9% of all possible lesion groupings still fell into a second response category, reflecting the effect of which particular lesions are chosen for measurement. CONCLUSIONS: Measuring larger numbers of lesions will decrease the variance. In this population, the variance decreased by at least 90% when six or more lesions were measured bidimensionally. Further confirmatory studies with larger series of patients are warranted before adopting this number as a criterion in clinical trials for assessing the activity of antineoplastic therapies.

Adult↗
PubMed2003

Prevalence of illicit drug use in young Australian women, patterns of use and associated risk factors.

OBJECTIVES: To estimate the prevalence of illicit drug use in young Australian women, determine their patterns of drug use and identify associated risk factors. METHODS: Data were collected in 2000 as part of the second survey of the youngest cohort in the Australian Longitudinal Study on Women's Health (n = 9512). RESULTS: Among women aged 22-27 years, 58% reported having used an illicit drug at some time with most (57%) having used cannabis. Amphetamines (16%), ecstasy/designer drugs (15%) and LSD (14%) were the next three most commonly used drugs. Four different patterns of drug use were identified: past users of cannabis only (39%); current users of cannabis only (17%); past multiple drug users (13%) and current multiple drug users (31%). Living in a de-facto relationship or never being married, living with non-family members, a history of physical abuse, sexual intercourse, smoking and binge drinking were associated significantly with exclusive use of cannabis and with use of multiple drugs compared to never using illicit drugs. Living with a partner, experience of sexual or emotional abuse, pregnancy, diagnosis of depression and taking sleeping medication were associated significantly with being a multiple drug user, but not for exclusive cannabis use. Multiple drug users had, on average, used cannabis 2-3 years before using any other drug. CONCLUSIONS: Given the strong association found between smoking, heavy drinking and drug use of varied patterns, public health initiatives targeted at preventing young women from smoking and drinking should additionally target illicit drug use.

Adolescent↗
PubMed2003

Trends in physical activity participation and the impact of integrated campaigns among Australian adults, 1997-99.

OBJECTIVES: To determine whether awareness of the moderate physical activity message and prevalence of participation changed among Australian adults between 1997 and 1999, and if changes differed across Australia. METHODS: Data were compared on awareness of the moderate physical activity message and on physical activity participation from identical national physical activity surveys in 1997 and 1999. RESULTS: In 1999, following integrated public health efforts, recognition of the Active Australia campaign was substantially higher in NSW/ACT (61.7%) than elsewhere (29.3%). Knowledge about benefits of moderate activity increased between 1997 and 1999, more so in States with public health campaigns. National participation in 'sufficient physical activity' declined between 1997 and 1999, from 63% to 57%, but the decline was smaller in NSW/ACT (4.4%) than in the other States (6.0%). CONCLUSIONS AND IMPLICATIONS: Declining trends in physical activity in Australia require increased public health investments, including strategic planning and public education, such as occurred in NSW (1997/98).

Adult↗
PubMed2003

Validation of body fluid analysis on the Coulter LH 750.

The role of the hematology laboratory in the analysis of body fluid has been to provide accurate enumeration of red blood cells (RBCs), total nucleated cells (TNCs), and differentials by manual analysis. Three hospitals (London Health Sciences Centre, University of Pittsburgh Medical Center, and University of Michigan Health System) participated in the assessment of the performance of automated analysis of body fluid by the Beckman Coulter LH 750, an impedance-based hematology analyzer. We evaluated the accuracy of analysis results for both the TNCs and RBCs of 372 samples (158 serous fluid, 148 cerebrospinal fluid [CSF], 66 synovial fluid) run on the LH 750 compared to results obtained from manual chamber counting. Of the 372 samples, 152 were suitable for evaluation of accuracy of the automated TNC. The remaining 220 samples were either flagged for interfering substances or the reference results were < 0.2 x 10(9)/L, below the background limit of the analyzer. Correlation coefficients for serous fluid were 0.895, P = .88; for CSF, 0.993, P = .84; and for synovial fluid, 0.836, P = .94. Of the 372 samples, 106 had RBC counts greater than 0.01 x 10(12)/L and were used for method comparison. Correlation coefficients for serous fluid were 0.957, P = .66; for CSF, 0.849, P = .55; and for synovial fluid, 0.667, P = .81. Linearity and precision studies showed excellent agreement for both TNC and RBC parameters. Low-level sensitivity excluded the majority of cerebrospinal (119) and a small number of peritoneal dialysate fluid samples (8), which require accurate enumeration at clinical decision points between 0 to 100 cells/microliter. In the case of synovial and serous fluids, however, most clinicians are interested in TNC counts above 0.2 x 10(9)/L, and RBC counts are relevant only if they are significantly increased (> or = 0.05 x 10(12)/L). Adopting the criteria of reporting TNC counts as < 0.2 x 10(9)/L or accurate enumeration on counts > or = 0.2 x 10(9)/L, clinically relevant results could be provided by automated analysis in 93.8% of serous fluids and 85.8% of synovial fluids.

Blood Cells↗
PubMed2002

Correlates of adults' participation in physical activity: review and update.

PURPOSE: To review and update the evidence relating to the personal, social, and environmental factors associated with physical activity (PA) in adults. METHODS: Systematic review of the peer-reviewed literature to identify papers published between 1998 and 2000 with PA (and including exercise and exercise adherence). Qualitative reports or case studies were not included. RESULTS: Thirty-eight new studies were located. Most confirmed the existence of factors already known to be correlates of PA. Changes in status were noted in relation to the influence of marital status, obesity, smoking, lack of time, past exercise behavior, and eight environmental variables. New studies were located which focused on previously understudied population groups such as minorities, middle and older aged adults, and the disabled. CONCLUSION: The newly reported studies tend to take a broader "ecological" approach to understanding the correlates of PA and are more focused on environmental factors. There remains a need to better understand environmental influences and the factors that influence different types of PA. As most of the work in this field still relies on cross-sectional studies, longitudinal and intervention studies will be required if causal relationships are to be inferred.

Adult↗