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Biomedical subjects

Werner H Mess

Publications and source records attributed to Werner H Mess.

8 recordsLinked to original sources
PubMed2005

Cerebral hyperperfusion syndrome.

Cerebral hyperperfusion syndrome (CHS) after carotid endarterectomy is characterised by ipsilateral headache, hypertension, seizures, and focal neurological deficits. If not treated properly it can result in severe brain oedema, intracerebral or subarachnoid haemorrhage, and death. Knowledge of CHS among physicians is limited. Most studies report incidences of CHS of 0-3% after carotid endarterectomy. CHS is most common in patients with increases of more than 100% in perfusion compared with baseline after carotid endarterectomy and is rare in patients with increases in perfusion less than 100% compared with baseline. The most important risk factors in CHS are diminished cerebrovascular reserve, postoperative hypertension, and hyperperfusion lasting more than several hours after carotid endarterectomy. Impaired autoregulation as a result of endothelial dysfunction mediated by generation of free oxygen radicals is implicated in the pathogenesis of CHS. Treatment strategies are directed towards regulation of blood pressure and limitation of rises in cerebral perfusion. Complete recovery happens in mild cases, but disability and death can occur in more severe cases. More information about CHS and early institution of adequate treatment are of paramount importance in order to prevent these potentially severe complications.

Algorithms↗
PubMed2005

Assessment of human atherosclerotic carotid plaque components with multisequence MR imaging: initial experience.

PURPOSE: To prospectively determine, by using a stepwise logistic regression model, the optimal magnetic resonance (MR) weighting (ie, pulse sequence) combinations for plaque assessment and corresponding cutoff values of relative signal intensities (rSIs). MATERIALS AND METHODS: Institutional review board approval and patient consent were obtained. Eleven patients (seven men, four women; mean age +/- standard deviation, 68 years +/- 4) with symptomatic carotid disease and stenosis of more than 70% were investigated at MR imaging before carotid endarterectomy. The MR images were matched with histologic features of the endarterectomy specimens (reference standard). The rSIs (compared with that of muscle tissue) from regions of interest were assessed qualitatively and semiquantitatively. For all major components (calcification, lipid core, intraplaque hemorrhage, and fibrous tissue), optimal cutoff points for the rSIs were determined for five MR weightings by means of receiver operating characteristic curves. The best predicting combinations of these five dichotomized MR weightings were selected by means of stepwise logistic regression analysis. The potential sensitivity and specificity of MR imaging for vulnerable plaque with hemorrhage and/or lipid core were determined. RESULTS: The same optimal MR weighting combinations for identifying the four plaque components were found with qualitative and semiquantitative analysis. Sensitivity and specificity for vulnerable plaque were 93% (95% confidence interval: 77%, 99%) and 96% (95% confidence interval: 86%, 100%), respectively, for the qualitative analysis and 76% (95% confidence interval: 56%, 90%) and 100% (95% confidence interval: 93%, 100%) for the semiquantitative analysis. CONCLUSION: This study demonstrates the potential of a systematic approach of atherosclerotic plaque assessment with multisequence MR imaging by using the information provided from five different MR weightings in a stepwise logistic regression model.

Aged↗
PubMed2003

Is there a side predilection for cerebrovascular disease?

In studies on carotid artery intima-media thickness and stroke, researchers implicitly assume that cerebrovascular abnormalities show a symmetrical distribution. To evaluate whether there is a difference in intima-media thickness between the 2 carotids, we compared left and right common carotid artery intima-media thickness as measured by B-mode ultrasonography in a group of 102 untreated hypertensive patients. This yielded a significant difference between both sides (left, 0.75+/-0.11 mm; right, 0.71+/-0.11 mm; P<0.001). This was associated with a higher cross-sectional area of the intima-media complex and a higher flow velocity at the left side. Arterial diameters, however, were not different. We also assessed whether there is a side preference with respect to cerebrovascular accidents. To this end, we explored our population-based Stroke Registry of 1843 subjects and indeed found a significantly higher incidence of nonlacunar cerebrovascular stroke at the left side, whereas lacunar infarcts were symmetrically distributed. Our findings suggest a predilection for cerebrovascular disease at the left side, which may be related to greater hemodynamic stress and intimal damage in the left carotid artery.

Adult↗
PubMed2003

The role of evoked potential monitoring in operative management of type I and type II thoracoabdominal aortic aneurysms.

Spinal cord ischemia with subsequent paraplegia remains the most dreaded and impressive complication following thoracoabdominal aortic aneurysm repair. Protective measures, such as cerebrospinal fluid drainage, distal aortic perfusion, and epidural cooling, have significantly reduced paraplegia rate. A major impediment is the inability to assess the efficacy of reattaching intercostal arteries or the contributing value of the adjunctive procedures during the operation. Monitoring motor-evoked potentials is a reliable technique to assess spinal cord integrity, dictating surgical strategies to restore and maintain blood supply to the gray matter. Based on motor-evoked potentials, hemodynamic and operative maneuvers during thoracoabdominal aortic aneurysm repair resulted, in our experience, in prevention of neurologic deficit in 98% of patients.

Aortic Aneurysm, Abdominal↗
PubMed2002

Assessment of spinal cord integrity during thoracoabdominal aortic aneurysm repair.

BACKGROUND: Monitoring motor-evoked potentials (MEPs) is an accurate technique to assess spinal cord integrity during thoracoabdominal aortic aneurysm (TAAA) repair, guiding surgical strategies to prevent paraplegia. METHODS: In 210 consecutive patients with type I (n = 75), type II (n = 103), and type III (n = 32) TAAA surgical repair was performed using left heart bypass, cerebrospinal fluid drainage, and MEPs monitoring. RESULTS: Reliable MEPs were registered in all patients. The median total number of patent intercostal and lumbar arteries was five. After proximal aortic crossclamping, MEP decreased below 25% of base line in 72 patients (34%) indicating critical spinal cord ischemia, which could be corrected by increasing distal aortic pressure. By using sequential clamping it appeared that in 43% of type I and II cases spinal cord circulation was supplied between T5 and L1, and 57% between L1 and L5. In type II and III cases cord perfusion was dependent upon lower lumbar arteries in 16% and pelvic circulation in 8%, necessitating reattachment of these segmental arteries. In 9% of patients critical ischemic MEP changes occurred without visible arteries, requiring aortic endarterectomy and selective grafting. One patient suffered early paraplegia and 2 delayed, and 2 patients had temporary neurologic deficit (5 of 210; 2.4%). CONCLUSIONS: In patients with TAAA, blood supply to the spinal cord depends upon a highly variable collateral system. Monitoring MEPs is an accurate technique for detecting cord ischemia, guiding surgical tactics to reduce neurologic deficit (2.4%).

Adult↗
PubMed2002

Spinal cord blood supply in patients with thoracoabdominal aortic aneurysms.

OBJECTIVE: In patients with thoracoabdominal aortic aneurysms (TAAAs), the blood supply to the spinal cord is highly variable and unpredictable because of obstructed intercostal and lumbar arteries. This study was performed for the prospective documentation of patent segmental arteries during TAAA repair and the assessment of their functional contribution to the spinal cord blood supply. METHODS: TAAA repair was performed in 184 consecutive patients (68 with type I aneurysm, 91 with type II, and 25 with type III) according to a protocol that included left heart bypass grafting, cerebrospinal fluid drainage, and the monitoring of motor-evoked potentials (MEPs). Patent intercostal and lumbar arteries were documented, and all reattached, selectively grafted, and oversewn segmental arteries were noted. MEP amplitude that decreased to less than 25% of baseline was considered an indication of critical spinal cord ischemia and prompted spinal cord revascularization. RESULTS: Adequate MEP levels were encountered in 183 of 184 patients. One patient had early paraplegia (absent MEPs), two patients had delayed paraplegia develop, and two patients had temporary paraparesis, which accounted for an overall neurologic deficit of 2.7%. The median total number of patent intercostal and lumbar arteries in type I, II, and III aneurysms was three, five, and five, respectively. In eight of 68 type I cases, no segmental arteries were seen between the fifth thoracic vertebrae (T5) and the first lumbar vertebrae (L1) and MEP levels remained adequate because of distal aortic perfusion. In 18 of 91 type II cases, the aortic segment T5 to L1 did not contain patent arteries, and in six of these patients, the segment L1 to L5 did not have lumbar arteries either. In the latter patients, MEP levels depended on the pelvic circulation provided with the left heart bypass graft. In the other 12 of 91 type II cases, the only patent arteries were the lumbar arteries between L3 and L5. The loss of MEPs could be corrected with the reattachment of these arteries. In seven of 25 type III cases, the MEP levels also depended on lumbar arteries L3 to L5 and in three of 25 cases, no segmental arteries were available and MEP levels recovered after the reperfusion of the pelvic circulation. With the combination of the findings of type II and III cases, spinal cord perfusion was directed by lower lumbar arteries in 16% of the cases (19 of 116) and pelvic circulation in 8% of the cases (nine of 116). CONCLUSION: In patients with TAAA, most intercostal and lumbar arteries are occluded and spinal cord perfusion depends on an eminent collateral network, which includes lumbar arteries and pelvic circulation. The monitoring of MEPs is a sensitive technique for the assessment of spinal cord ischemia and the identification of segmental arteries that critically contribute to spinal cord perfusion. Surgical strategies on the basis of this technique reduced the incidence rate of neurologic deficit to less than 3%.

Adult↗
PubMed2002

Chlamydia pneumoniae serology is associated with thrombosis-related but not with plaque-related microembolization during carotid endarterectomy.

BACKGROUND AND PURPOSE: Chlamydia pneumoniae has repeatedly been associated with atherosclerotic disease. Our study was designed to clarify whether this association is based on C pneumoniae-induced transformation of a stable into an unstable atherosclerotic plaque or on stimulation of hypercoagulability leading to increased thrombotic arterial occlusions by C pneumoniae infection. Transcranial Doppler ultrasonographic monitoring of the middle cerebral artery during carotid endarterectomy offers the opportunity to study, before removal of the plaque, atherothrombotic emboli dislodging from an unstable carotid plaque (plaque-related emboli) and emboli related to (excessive) thrombus formation at the endarterectomy site after removal of the plaque and restoration of flow (thrombosis-related emboli). METHODS: C pneumoniae IgA (> or =1/16) and IgG (> or =1/64) seropositivity was assessed in 53 patients with symptomatic carotid artery disease undergoing carotid endarterectomy. The removed carotid plaques were studied histologically to assess plaque instability. RESULTS: Plaque- and thrombosis-related emboli were registered in 43 patients with an adequate transtemporal window. IgA seropositivity (58%) was associated significantly with thrombosis-related embolization (P=0.030) but not with plaque-related embolization or with histological plaque instability. CONCLUSIONS: C pneumoniae serology is associated with microembolization after endarterectomy and restoration of flow. Since these microemboli represent platelet aggregations and are related to cerebrovascular complications, our data suggest that C pneumoniae infection contributes to cerebrovascular events in patients with carotid artery disease through stimulation of thrombosis.

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