Biomedical subjects

Werner Winter

Publications and source records attributed to Werner Winter.

5 recordsLinked to original sources

PubMed2006

Loading of bone surrounding implants through three-unit fixed partial denture fixation: a finite-element analysis based on in vitro and in vivo strain measurements.

Implant-borne fixed partial dentures (FPDs), whether cementable or screwable superstructures, ought to display a true passive fit. The objective of this in vivo-based finite-element analysis is, therefore, to quantify the degree of stress which occurs in the bone around the implants as a result of the fixation of cemented and screw-retained FPDs. On the basis of a simulated patient situation with two implants, six groups of implant-supported superstructures containing 10 samples each were fabricated. Strain gauges which were mounted on the pontics of the restorations were subsequently used to take in vivo measurements (Ethics Commission Approval No. 2315). Taking the values obtained as a basis, the von Mises equivalent stress was chosen to illustrate bone loading in three-dimensional finite-element models. Superstructure fixation caused residual interface stress as high as 30 MPa. Similar stress magnitudes can be observed for axial implant loading of 200 N. Assuming that the axial loading of a single implant with 200 N is within the bone's physiological range, it can be concluded that the degree of stress resulting from the fixation of superstructures alone does not constitute a risk.

Cementation↗

PubMed2005

Multivariate analysis of nuclear magnetic resonance data--characterization of critical drug substance quality of gentamicin sulfate.

Fourteen gentamicin sulfate lots collected from international markets showed high quantities of impurities (approximately 30% of studied lots). 1H NMR spectroscopy as a primary analytical method was applied in order to validate the quantification results obtained from micellar electrokinetic chromatography method (MEKC). In this study, 1H NMR data of 46 gentamicin sulfate drug substance lots were used to classify the lots by means of principal component analysis (PCA) of 14 1H NMR-signals in the 5.0-6.0 ppm region. Three main groups could be classified: high purity (3 lots), average quality (28 lots) and low purity (14 lots); one lot proved to be atypical. The 14 normalized signal heights in the 5.0-6.0 ppm region are predictive for purity quality according to a partial least squares (PLS)-model with sum of all impurities as Y-variable (measured by MEKC).

Chromatography, Micellar Electrokinetic Capillary↗

PubMed2004

Cement fixation and screw retention: parameters of passive fit. An in vitro study of three-unit implant-supported fixed partial dentures.

It is generally assumed that passively fitting superstructures are a prerequisite for long-lasting implant success. In the study presented, the strain development of three-unit implant fixed partial dentures (FPDs) was evaluated at the bone surrounding the implant and on the superstructure using a strain gauge technique. Six groups of three-unit FPDs representing the commonly used techniques of bridge fabrication were investigated with 10 samples each, in order to quantify the influence of impression technique, mode of fabrication and retention mechanism on superstructure fit. Two ITI implants (Straumann, Waldenburg, Switzerland) were anchored in a measurement model according to a real-life patient situation and strain gauges were fixed mesially and distally adjacent to the implants and on the bridge pontics. The developing strains were recorded during cement setting and screw fixation. For statistical analysis, multivariate two sample tests were performed setting the level of significance at P=0.1. None of the investigated bridges revealed a truly passive fit without strains occurring. About 50% of the measured strains were found to be due to impression taking and model fabrication, whereas the remaining 50% were related to laboratory inaccuracies. The two impression techniques used did not reveal any significant differences in terms of precision. Both modes of fixation--i.e. cement and screw retention--provoked equally high stress levels. In the fabrication of screw-retained FPDs, similar results were obtained from the use of burn-out plastic copings and the technique of casting wax moulds to premachined components. Bonding bridge frames onto gold cylinders directly on the implants significantly reduces strain development.

Aged↗

PubMedDate not supplied

In vitro study on passive fit in implant-supported 5-unit fixed partial dentures.

PURPOSE: Fabrication and retention methods have an influence on the passivity of superstructure fit. The objective of the study was to quantify the strain development of various cemented and screw-retained fixed partial dentures (FPDs). MATERIALS AND METHODS: Forty samples of 4 different types of FPDs (10 of each type) were investigated. Each sample had 3 ITI implant abutments and 2 pontics. The 3 implants were anchored in a straight-line configuration in a measurement model simulating a real-life patient situation. Strain gauges were mounted close to the implants and on the pontics. The developing strains were recorded during cement setting and screw fixation. For statistical analysis, multivariate 2-sample tests were performed, with the level of significance set at P = .1. RESULTS: All FPDs investigated revealed a considerable amount of strain, with no significant difference between cement and screw retention. Furthermore, no significant difference was found between the conventional fabrication modes for screw-retained FPDs. The lowest strains were found in prostheses that were intraorally bonded onto gold cylinders. DISCUSSION: Because bonding of the superstructure in the oral cavity may compensate for impression and laboratory variables, restorations with the best possible passive fit can result from this retention technique. Before this technique can be recommended, the long-term stability of the adhesive layer should be investigated. CONCLUSIONS: As an absolute passive fit of superstructures is not possible using conventional clinical and laboratory procedures, and as clinical fit-evaluation methods often do not detect "hidden" inaccuracies, the more sensitive strain-gauge technique should be utilized for an objective accuracy test. Reference strain values from implant-supported prostheses that have served without complications could help define a "biologically acceptable fit.

Aged↗

PubMedDate not supplied

Fixation of 5-unit implant-supported fixed partial dentures and resulting bone loading: a finite element assessment based on in vivo strain measurements.

PURPOSE: It is believed that implant-supported fixed partial dentures (FPDs) should display passive fit. The objective of this in vivo-based finite element analysis (FEA) was to quantify the magnitude of bone loading occurring on account of the fixation of cemented or screw-retained 5-unit superstructures. MATERIALS AND METHODS: Based on a patient situation with 3 implants, 4 different groups of restorations with 10 samples each were fabricated. Strain gauges on the pontics of the restorations were used for in vivo measurements. Using the values obtained, bone loading in 3-dimensional FE models was simulated as von Mises equivalent stress. RESULTS: The in vivo measured mean strain values ranged from 32 microm/m to 458 microm/m at the different sites. FEA revealed stresses between 5 and 30 MPa in the cortical area, while in trabecular bone values ranging from 2 MPa to 5 MPa were observed. Stress of a similar magnitude was found for axial implant loading with 200 N. DISCUSSION: Assuming that the axial loading of a single implant with 200 N is within the realm of the bone's adaptation ability, it would appear that the amount of stress resulting from the fixation of superstructures alone does not constitute a risk. CONCLUSIONS: The level of precision of fit which can be obtained in superstructure fabrication would appear to suffice to produce restorations that do not cause bone damage.

Bite Force↗