Measurement of single molecular interactions by dynamic force microscopy.
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Humans↗
Biomedical subjects
Wilfried Grange
Publications and source records attributed to Wilfried Grange.
Temperature dependence of unbinding forces between complementary DNA strands.
Force probe techniques such as atomic force microscopy can directly measure the force required to rupture single biological ligand receptor bonds. Such forces are related to the energy landscape of these weak, noncovalent biological interactions. We report unbinding force measurements between complementary strands of DNA as a function of temperature. Our measurements emphasize the entropic contributions to the energy landscape of the bond.
Base Sequence↗