Biomedical subjects

William A Sands

Publications and source records attributed to William A Sands.

18 recordsLinked to original sources

PubMed2006

Biomechanical research in artistic gymnastics: a review.

Biomechanical research into artistic gymnastics has grown substantially over the years. However, most research is still skill oriented with few tries at generalization. Consequently, our understanding of the principles and bases of the sport, although improved, is still marginal with gaps in knowledge about technique attributes throughout the sport. For that reason, this review begins with an attempt to identify important variables contributing to successful performance. The review is presented in clusters of work in similar apparatuses culminating in Tables offering an 'at a glance' summary of knowledge in each cluster. The last section of the review tries to give some direction to future biomechanical research in gymnastics in issues relating to data collection--two-dimensional or three-dimensional, image size, frame rate--and analysis, such as descriptive or explanatory, simulation and optimization, and statistical issues.

Biomechanical Phenomena↗

PubMed2006

Hitting the vault board: implications for vaulting take-off--a preliminary investigation.

Gymnastics vaulting relies on a specialized take-off board for propulsion during the take-off phase of the vault. There is little information on the vault board and its behaviour. The aim of this study was to characterize the behaviour of the vault board during handspring drill take-offs of young male gymnasts (n = 36). The side of the top surface of the vault board and the wooden base were marked with three reflective markers, placed at the end of the vault board nearest the vault table and the centres of the two rearmost coil springs. The vault board surface was divided into two areas, rear and middle, based on marker location. The gymnasts' groups were determined from the location of the gymnast's lateral malleolus at vault board contact. Landings with the malleolus directly above or behind the rearmost marker were considered rear landings; landings with the malleolus forward of the rearmost marker were considered middle landings. Marker movements were automatically digitized and the right malleolus was hand digitized at 120 Hz. The maximum vertical displacement, vertical deflection time, and vertical velocity at take-off of the vault board markers did not differ statistically between board contact groups (all p > 0.05). The lateral malleolus velocity components also did not differ between board contact groups. Some low to moderately strong correlations were observed between the various marker displacements, durations and take-off velocities. Modest correlations were obtained between board markers and right malleolus velocities. The results indicate that foot contact on the vault board, as defined here, did not result in differences in board marker behaviour or right lateral malleolus velocities. This information does not support the idea that vault board contacts at the rear of the vault board are worse than contacts near the middle of the vault board. More research is needed to ascertain the role of the vault board's vibration characteristics to whole body actions that are observed in the subsequent preflight phase.

Adolescent↗

PubMed2006

Stretching for performance enhancement.

Stretching exercises have been considered an essential component of physical training programs for decades. Cross-sectional studies have demonstrated that flexibility measures are related to performance in many sports, suggesting that using stretching to enhance flexibility may indirectly improve performance. However, observations by athletes and coaches have called into question the universal prescription of stretching for the purpose of enhancing sport performance, and this skepticism is being supported by a growing body of empirical data. Whereas the tissue responses and adaptations to stretching have been the most widely studied area of stretching research, comparatively little is understood regarding the neural influences on range of motion, which may have more applicability when the range of motion needs are related to skilled movements as in sport.

Biomechanical Phenomena↗

PubMed2006

Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells.

Here, we demonstrate that elevation of intracellular cyclic AMP (cAMP) in vascular endothelial cells (ECs) by either a direct activator of adenylyl cyclase or endogenous cAMP-mobilizing G protein-coupled receptors inhibited the tyrosine phosphorylation of STAT proteins by an interleukin 6 (IL-6) receptor trans-signaling complex (soluble IL-6Ralpha/IL-6). This was associated with the induction of suppressor of cytokine signaling 3 (SOCS-3), a bona fide inhibitor in vivo of gp130, the signal-transducing component of the IL-6 receptor complex. Attenuation of SOCS-3 induction in either ECs or SOCS-3-null murine embryonic fibroblasts abolished the inhibitory effect of cAMP, whereas inhibition of SHP-2, another negative regulator of gp130, was without effect. Interestingly, the inhibition of STAT phosphorylation and SOCS-3 induction did not require cAMP-dependent protein kinase activity but could be recapitulated upon selective activation of the alternative cAMP sensor Epac, a guanine nucleotide exchange factor for Rap1. Consistent with this hypothesis, small interfering RNA-mediated knockdown of Epac1 was sufficient to attenuate both cAMP-mediated SOCS-3 induction and inhibition of STAT phosphorylation, suggesting that Epac activation is both necessary and sufficient to observe these effects. Together, these data argue for the existence of a novel cAMP/Epac/Rap1/SOCS-3 pathway for limiting IL-6 receptor signaling in ECs and illuminate a new mechanism by which cAMP may mediate its potent anti-inflammatory effects.

3T3 Cells↗

PubMed2006

Flexibility enhancement with vibration: Acute and long-term.

INTRODUCTION: The most popular method of stretching is static stretching. Vibration may provide a means of enhancing range of motion beyond that of static stretching alone. PURPOSE: This study sought to observe the effects of vibration on static stretching to determine whether vibration-aided static stretching could enhance range of motion acquisition more than static stretching alone in the forward split position. METHODS: Ten highly trained male volunteer gymnasts were randomly assigned to experimental (N = 5) and control (N = 5) groups. The test was a forward split with the rear knee flexed to prevent pelvic misalignment. Height of the anterior iliac spine of the pelvis was measured at the lowest split position. Athletes stretched forward and rearward legs to the point of discomfort for 10 s followed by 5 s of rest, repeated four times on each leg and split position (4 min total). The experimental group stretched with the device turned on; the control group stretched with the device turned off. A pretest was followed by an acute phase posttest, then a second posttest measurement was performed following 4 wk of treatment. Difference scores were analyzed. RESULTS: The acute phase showed dramatic increases in forward split flexibility for both legs (P < 0.05), whereas the long-term test showed a statistically significant increase in range of motion on the right rear leg split only (P < 0.05). Effect sizes indicated large effects in all cases. CONCLUSION: This study showed that vibration can be a promising means of increasing range of motion beyond that obtained with static stretching in highly trained male gymnasts.

Biomechanical Phenomena↗

PubMed2006

Any effect of gymnastics training on upper-body and lower-body aerobic and power components in national and international male gymnasts?

Aerobic and anaerobic performance of the upper body (UB) and lower body (LB) were assessed by arm cranking and treadmill tests respectively in a comparison of national (N) and international (I) male gymnasts. Force velocity and Wingate tests were performed using cycle ergometers for both arms and legs. In spite of a significant difference in training volume (4- 12 vs. 27-34 h.wk(-1) for N and I, respectively), there was no significant difference between N and I in aerobic and anaerobic performance. Upper body and LB maximal oxygen uptake (VO(2)max) values were 34.44 +/- 4.62 and 48.64 +/- 4.63 ml.kg(-1).min(-1) vs. 33.39 +/- 4.77 and 49.49 +/- 5.47 ml.kg(-1).min(-1), respectively, for N and I. Both N and I had a high lactic threshold (LT), at 76 and 82% of VO(2)max, respectively. Values for UB and LB force velocity (9.75 +/- 1.12 and 15.07 +/- 4.25 vs. 10.63 +/- 0.95 and 15.87 +/- 1.25 W.kg(-1)) and Wingate power output (10.43 +/- 0.74 and 10.98 +/- 3.06 vs. 9.58 +/- 0.60 and 13.46 +/- 1.34 W.kg(-1)) were also consistent for N and I. These findings confirm the consistency of VO(2)max values presented for gymnasts in the last 4 decades, together with an increase in peak power values. Consistent values for aerobic and anaerobic performance suggest that the significant difference in training volume is related to other aspects of perfomance that distinguish N from I gymnasts. Modern gymnastics training at N and I levels is characterized by a focus on relative strength and peak power. In the present study, the high LT is a reflection of the importance of strength training, which is consistent with research for sports such as wrestling.

Adolescent↗

PubMed2005

Adenosine receptors and the control of endothelial cell function in inflammatory disease.

The nucleoside adenosine accumulates in many tissues following the onset of ischaemia and inflammation. This initiates a series of protective mechanisms in target cells upon binding and activation of a family of four G-protein-coupled cell surface adenosine receptor (AR) proteins. The magnitude and duration of adenosine's effects are dictated by the identity and expression levels of each receptor subtype on individual cell types within the hypoxic microenvironment. Given the key role of endothelial cells (ECs) in the development of inflammatory diseases, such as sepsis, rheumatoid arthritis (RA) and atherosclerosis, ARs represent attractive targets for therapeutic intervention in these conditions. In this review, we examine several critical aspects of endothelial function in vivo, assess the role of individual AR subtypes in these events and, where known, discuss the molecular mechanisms by which specific ARs exert their effects.

Animals↗

PubMed2005

Anthropometric and physical abilities profiles: US National Skeleton Team.

The aim of this study was to characterize sprint ability, anthropometry, and lower extremity power in the US National Team Skeleton athletes. Fourteen athletes (male n = 7; mean +/- SD: height 1.794 +/- 0.063 m, body mass 81.2 +/- 3.7 kg, age 26.9 +/- 4.1 years; female n = 7; 1.642 +/- 0.055 m, 60.1 +/- 5.9 kg, 27.3 +/- 6.9 years) volunteered to participate. Sprinting ability was measured over multiple intervals using custom infrared timing gates in both an upright and a crouched sprint. The crouched sprint was performed while pushing a wheeled-simulated skeleton sled on rails on an outdoor skeleton and bobsleigh start track. Crouched skeleton sprint starts were able to achieve about 70% to 85% of the upright sprint times. The mean somatotype ratings for females were: 3.5-3.5-2.1, and males: 3.6-4.9-1.9. Lower extremity strength and power were measured via vertical jumps on a portable force platform using squat and countermovement jumps, and jumps with added mass. Jump height, power, rate offorce development and peak force were determined from force-time data. Lower extremity strength and power were strongly correlated with both upright and crouched sprint times. The results indicated that these athletes are strong sprinters with varying body structures, mostly mesomorphic, and that stronger and more powerful athletes tend to be better starters.

Adult↗

PubMed2005

Force-time curve characteristics of dynamic and isometric muscle actions of elite women olympic weightlifters.

Six elite women weightlifters were tested to evaluate force-time curve characteristics and intercorrelations of isometric and dynamic muscle actions. Subjects performed isometric and dynamic mid-thigh clean pulls at 30% of maximal isometric peak force and 100 kg from a standardized position on a 61.0 x 121.9 cm AMTI forceplate. Isometric peak force showed strong correlations to the athletes' competitive snatch, clean and jerk, and combined total (r = 0.93, 0.64, and 0.80 respectively). Isometric rate of force development showed moderate to strong relationships to the athletes' competitive snatch, clean and jerk, and combined total (r = 0.79, 0.69, and 0.80 respectively). The results of this study suggest that the ability to perform maximal snatch and clean and jerks shows some structural and functional foundation with the ability to generate high forces rapidly in elite women weightlifters.

Adult↗

PubMed2005

Plaudits and pitfalls in studying elite athletes.

The study of elite athletes, because of their rarity, renders statistical power difficult to achieve, control groups difficult or impossible to find, and generalizability difficult to demonstrate. Alternative methods of analysis may be better suited to such study.

Humans↗

PubMed2005

Relationship of maximum strength to weightlifting performance.

PURPOSE: The primary objective was to assess the relationship of maximum strength to weightlifting ability using established scaling methods. The secondary objective was to compare men and women weightlifters on strength and weightlifting ability. METHODS: Two correlational observations were carried out using Pearson's r. In the first observation (N = 65) the relationship of dynamic maximum strength (one-repetition maximum (1RM) squat) was compared with weightlifting ability; in the second observation (N = 16), isometric maximum strength (midthigh pull) was studied. Scaling methods for equating maximum strength and weightlifting results were used (load x (Ht), load x kg, load x lbm(-1), allometric, and Sinclair formula) to assess the association between measures of maximum strength and weightlifting performance. RESULTS: Using scaled values; correlations between maximum strength and weightlifting results were generally strong in both observations (e.g., using allometric scaling for the 1RM squat vs the 1RM snatch: r = 0.84, N = 65). Men were stronger than women (e.g., 1RM squat, N = 65: men = 188.1 +/- 48.6 kg; women = 126.7 +/- 28.3 kg); differences generally held when scaling was applied (e.g., 1RM squat scaled with the Sinclair formula: men = 224.7 +/- 36.5 kg; women = 144.2 +/- 25.4 kg). CONCLUSIONS: When collectively considering scaling methods, maximum strength is strongly related to weightlifting performance independent of body mass and height differences. Furthermore, men are stronger than women even when body mass and height are obviated by scaling methods.

Adolescent↗

PubMed2004

Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3.

Here we demonstrate that phosphorylation of the sphingosine-1-phosphate (S1P) receptor S1P(3) is increased specifically in response to S1P. Truncation of the receptor's carboxyl-terminal domain revealed that the presence of a serine-rich stretch of residues between Leu332 and Val352 was essential to observe this effect. Although agonist-occupied wild-type (WT) S1P(3) could be phosphorylated in vitro by G-protein-coupled receptor kinase 2 (GRK2), a role of S1P(3) phosphorylation in controlling S1P(3)-G(q/11) coupling was excluded since A) a phosphorylation-resistant S1P(3) mutant desensitised in a manner indistinguishable from the WT receptor and was phosphorylated to a greater extent than the WT receptor by GRK2 in vitro, and B) co-expression with GRK2 or GRK3 failed to potentiate S1P(3) phosphorylation. S1P(3) phosphorylation was also not required for receptor sequestration away from the cell surface. Together, these data suggest that S1P(3) function is not subject to conventional regulation by GRK phosphorylation and that novel aspects of S1P(3) function distinct from classical G-protein coupling and receptor internalisation may be controlled its carboxyl-terminal domain.

Amino Acid Sequence↗

PubMed2004

Specific inhibition of nuclear factor-kappaB-dependent inflammatory responses by cell type-specific mechanisms upon A2A adenosine receptor gene transfer.

Adenosine is a potent inhibitor of inflammatory processes, and the A(2A) adenosine receptor (A(2A)AR) plays a key nonredundant role as a suppresser of inflammatory responses in vivo. In this study, we demonstrate that increasing A(2A)AR gene expression suppressed multiple inflammatory responses in both human umbilical vein endothelial cells (HUVECs) and rat C6 glioma cells in vitro. In particular, the induction of the adhesion molecule E-selectin by either tumor necrosis factor alpha (TNFalpha) or Escherichia coli lipopolysaccharide (LPS) was reduced by more than 70% in HUVECs, whereas inducible nitric-oxide synthase (iNOS) induction was abolished in C6 cells after exposure to interferon-gamma in combination with LPS and TNFalpha, suggesting that the receptor inhibited a common step in the induction of each of these pro-inflammatory genes. Consistent with this hypothesis, A(2A)AR expression inhibited the activation of NF-kappaB, a key transcription factor whose proper function was essential for optimal iNOS and E-selectin induction. However, although NF-kappaB binding to target DNA was severely compromised in both cell types, the mechanisms by which this occurred were distinct. In C6 cells, A(2A)AR expression blocked IkappaBalpha degradation by inhibiting stimulus-induced phosphorylation, whereas in HUVECs, A(2A)AR expression inhibited NF-kappaB translocation to the nucleus independently of any effect on IkappaBalpha degradation. Together, these observations suggest that A(2A)AR-mediated inhibition NF-kappaB activation is a critical aspect of its anti-inflammatory signaling properties and that the molecular basis of this inhibition varies in a cell type-specific manner.

Cell Adhesion↗

PubMed2004

Comparison of the Wingate and Bosco anaerobic tests.

The purpose of this study was to compare the Wingate cycling and Bosco repeated jumps anaerobic tests. Eleven men (21.36 +/- 1.6 years; 179.1 +/- 9.3 cm; 78.7 +/- 11.0 kg) and 9 women (21.89 +/- 3.66 years; 171.8 +/- 10.0 cm; 75.9 +/- 21.4 kg), all university athletes, volunteered to participate. Subjects performed each test in random order. The tests consisted of a 30-second Wingate test and a 60-second Bosco test. The Wingate test was conducted using a Monark cycle ergometer and the Bosco test was conducted on a force platform. Following the performance of each test, peak lactate concentrations were determined. Average and peak power values were statistically greater in men and on the Bosco test. Peak lactate values were statistically greater in men but did not differ based on test. Correlations between peak lactate concentrations between tests and lactate values with peak or average power were not statistically significant. The relationship between peak power between tests was statistically significant among men, but not women. The results of the study indicated that the Bosco and Wingate tests, which both measure anaerobic characteristics, appear to measure different aspects of anaerobic power and capacity. The Bosco test also may be inappropriate for athletes who are not well trained in jumping.

Adult↗

PubMed2004

The importance of isometric maximum strength and peak rate-of-force development in sprint cycling.

This study was designed to investigate the relationship of whole-body maximum strength to variables potentially associated with track sprint-cycling success. These variables included body composition, power measures, coach's rank, and sprint-cycling times. The study was carried out in 2 parts. The first part (n = 30) served as a pilot for the second part (n = 20). Subjects for both parts ranged from international-caliber sprint cyclists to local-level cyclists. Maximum strength was measured using an isometric midthigh pull (IPF). Explosive strength was measured as the peak rate-of-force development (IPRFD) from the isometric force-time curve. Peak power was estimated from countermovement (CMJPP) and static vertical jumps (SJPP) and measured by modified Wingate tests. Athletes were ranked by the U.S. national cycling coach (part 1). Sprint times (from a standing start) were measured using timing gates placed at 25, 82.5, 165, 247.5, and 330 m of an outdoor velodrome (part 2). Maximum strength (both absolute and body-mass corrected) and explosive strength were shown to be strongly correlated with jump and Wingate power. Additionally, maximum strength was strongly correlated with both coach's rank (parts 1 and 2) and sprint cycling times (part 2). The results suggest that larger, stronger sprint cyclists have an advantage in producing power and are generally faster sprint cyclists.

Adult↗

PubMed2004

The relationship between vertical jump power estimates and weightlifting ability: a field-test approach.

The purpose of this study was to assess the usefulness of the vertical jump and estimated vertical-jump power as a field test for weightlifting. Estimated PP output from the vertical jump was correlated with lifting ability among 64 USA national-level weightlifters (junior and senior men and women). Vertical jump was measured using the Kinematic Measurement System, consisting of a switch mat interfaced with a laptop computer. Vertical jumps were measured using a hands-on-hips method. A counter-movement vertical jump (CMJ) and a static vertical jump (SJ, 90 degrees knee angle) were measured. Two trials were given for each condition. Test-retest reliability for jump height was intra-class correlation (ICC) = 0.98 (CMJ) and ICC = 0.96 (SJ). Athletes warmed up on their own for 2-3 minutes, followed by 2 practice jumps at each condition. Peak power (PP) was estimated using the equations developed by Sayers et al. (24). The athletes' current lifting capabilities were assessed by a questionnaire, and USA national coaches checked the listed values. Differences between groups (i.e., men versus women, juniors versus resident lifters) were determined using t-tests (p < or = 0.05). Correlations were determined using Pearson's r. Results indicate that vertical jumping PP is strongly associated with weightlifting ability. Thus, these results indicate that PP derived from the vertical jump (CMJ or SJ) can be a valuable tool in assessing weightlifting performance.

Adolescent↗

PubMed2003

Effect of active and passive recovery on blood lactate and performance during simulated competition in high level gymnasts.

The purpose of this study was to investigate the effect of two recovery strategies between men's gymnastics events on blood lactate removal (BL) and performance as rated by expert "blind" judges. Twelve male gymnasts (21.8 +/- 2.4 years) participated. The sessions were composed of routine performances in the six Olympic events, which were separated by 10 min of recovery. All gymnasts performed two recovery protocols between events on separate days: Rest protocol, 10 min rest in a sitting position; Combined protocol, 5 min rest and 5 min self-selected active recovery. Three blood samples were taken at 2, 5, and 10 min following each event. Gymnasts produced moderate values of BL following each of the six events (2.2 to 11.6 mmol.L-1). There was moderate variability in BL values between events that could not be accounted for by the athlete's event performance. Gymnasts showed higher BL concentration (p > .05) and significantly (p < .05) higher scoring performances (as rated by a panel of certified judges) when they used a combined recovery between gymnastics events rather than a passive recovery (delta BL = 40.51% vs. 28.76% of maximal BL, p < .05, and total score = 47.28 +/- 6.82 vs. 38.39 +/- 7.55, p < .05, respectively).

Adult↗

PubMed2002

A kinematic comparison of four abdominal training devices and a traditional abdominal crunch.

Abdominal exercises are often performed on roller or rocker mechanisms, which have been aggressively promoted through the television and print media. However, justifications are lacking as to why these devices are superior to traditional abdominal exercises such as crunches. This study sought to describe and compare the range of motion (ROM) of several joints during crunches performed on 4 different abdominal conditioning devices (2 roller and 2 pivot types) and a traditional crunch exercise. Ten men (29 +/- 5.87 years, 177.5 +/- 6.46 cm, 80.96 +/- 11.72 kg) and 10 women (33.4 +/- 10.16 years, 162.23 +/- 3.83 cm, 56.99 +/- 7.36 kg) subjects agreed to participate in the study. Subjects were videotaped in the sagittal plane (60 Hz) using standard kinematic methods. Reflective markers were placed on the right temple, auditory meatus, shoulder, hip, knee, ankle, heel, toe, and 2 sternum markers placed on a foam piece strapped to the subject's chest. The videotaped movements were automatically digitized (PEAK5 2-D) and the data smoothed using a Butterworth filter. Relative angular ROMs of the head (temple, auditory meatus, shoulder); neck (auditory meatus, shoulder, hip); trunk (near sternum, shoulder, hip); hip (shoulder, hip, knee); sternum/head (sternum near and sternum far with temple and auditory meatus); sternum/trunk (sternum near and sternum far with shoulder and hip); and a sum of 4 angles (head, neck, trunk, hip) were calculated. Sex by equipment repeated measures analyses of variance (ANOVAs) were calculated on the angles of the 5 exercises. When no main effect for sex was found, the data were collapsed across sex and a one-way ANOVA with repeated measures was calculated on the resulting data. Post hoc analyses of pairwise differences were calculated using Tukey's honestly significant difference statistic. Results showed that crunches performed with the abdominal devices resulted in less ROM in all angles measured when compared with a traditional crunch. The traditional crunch exercise was most closely simulated by the pivot-type devices. The results indicated that prescription of abdominal conditioning exercises via these devices results in training through smaller ROMs compared with a traditional crunch. The specific angle changes may require careful judgment as to appropriate application for exercisers with specific back and neck motion limitations.

Abdominal Muscles↗