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Biomedical subjects

William E Palmer

Publications and source records attributed to William E Palmer.

At least 19 recordsLinked to original sources
PubMed2006

Use of gadolinium chelate to confirm epidural needle placement in patients with an iodinated contrast reaction.

OBJECTIVE: When performing epidural steroid injections for the management of chronic back pain, imaging guidance and a limited epidurogram improve accuracy of needle placement and ensure appropriate delivery of the injectate into the epidural space. We describe our experience using a gadolinium chelate as an alternative contrast agent for limited epidurography in patients with a history of an iodinated contrast reaction. DESIGN: Thirty-eight of 2,067 (1.8%) epidural steroid injections performed in our department over a 25-month period (December 2003-January 2006) employed gadolinium. All injections were performed in the lumbar spine employing a paramedian interlaminar approach. Procedural notes and patient charts were reviewed to evaluate for immediate or delayed complications related to incorrect intrathecal or intravascular needle placement. A retrospective analysis of selected fluoroscopic spot images was performed to evaluate confidence of epidural needle placement; this analysis compared these spot images against those obtained from age- and gender-matched control patients in whom iodinated contrast was used to confirm needle placement. RESULTS: Real-time fluoroscopic guidance permitted confident visualization of an epidurogram at the time of procedure in all 38 cases as documented in the procedural report, and no procedure resulted in a complication due to incorrect needle placement. Retrospective review of fluoroscopic spot images revealed at least moderate confidence of epidural needle placement by both readers in 29/38 cases (76.3%). Fluoroscopic spot images obtained using gadolinium yielded significantly less confidence than images obtained in control patients whose procedures were performed using iodinated contrast (P < 0.01). However, operators were sufficiently confident in needle placement based on real-time fluoroscopic images (not available in our subsequent review) to inject anesthestic in all 38 cases, despite the immediate consequences that could result from intrathecal administration. During the same time period, there were 11/2,067 (0.5%) instances of intrathecal needle placement discovered during attempted epidurography despite the use of fluoroscopy for needle guidance and reliance on loss-of-resistance technique. CONCLUSION: Gadolinium chelate represents a safe and useful alternative contrast agent for confirmation of epidural needle placement in patients with an iodinated contrast allergy.

Adult↗
PubMed2006

Distal clavicular osteolysis: MR evidence for subchondral fracture.

PURPOSE: To investigate the association between distal clavicular osteolysis and subchondral fractures of the distal clavicle at MRI. MATERIALS AND METHODS: This study was approved by the hospital human research committee, which waived the need for informed consent. Three radiologists retrospectively analyzed 36 shoulder MR examinations in 36 patients with imaging findings of distal clavicular osteolysis. The presence of a subchondral fracture of the distal clavicle, abnormalities of the acromioclavicular joint, rotator cuff tears and labral tears were assessed by MRI. These cases were then compared with 36 age-matched controls. RESULTS: At MRI, 31 of 36 patients (86%) had a subchondral line within the distal clavicular edema, consistent with a subchondral fracture. Of the 36 patients, 32 (89%) had fluid in the acromioclavicular joint, while 27 of 36 patients (75%) had cysts or erosions in the distal clavicle. There were 13 patients (36%) with associated labral tears, while eight patients (22%) had partial-thickness rotator cuff tears. In the control group one of 36 (3%) had a subchondral line (P<0.05), while ten of 36 (28%) had rotator cuff tears and 13 of 36 (36%) had labral tears. These latter two were not statistically significant between the groups. CONCLUSION: A distal clavicular subchondral fracture is a common finding in patients with imaging evidence of distal clavicular osteolysis. These subchondral fractures may be responsible for the propensity of findings occurring on the clavicular side of the acromioclavicular joint.

Adult↗
PubMed2006

Shoulder magnetic resonance imaging.

MRI provides excellent soft tissue contrast and allows for multiplanar imaging in anatomic planes. Because of these advantages MRI has become the study of choice for imaging of shoulder pathology. Some structures, such as the rotator cuff, humeral head contour, and glenoid shape, are evaluated well with conventional MRI. When more sensitive evaluation of the labrum, capsule, articular cartilage, and glenohumeral ligaments is required or when a partial-thickness rotator cuff tear is suspected,magnetic resonance arthrography with intra-articular contrast can be performed. For MR arthrography contrast is injected directly into the glenohumeral joint. This article reviews the appearances of normal anatomic structures in MRI of the shoulder and disorders involving the rotator cuff and glenoid labrum.

Humans↗
PubMed2006

MR imaging of the rotator cuff.

MR imaging is the optimal method for evaluating suspected rotator cuff pathology. Current techniques of fast spin-echo imaging without and with fat suppression allow accurate identification and characterization of tendinous and myotendinous abnormalities of the rotator cuff. Impingement disorders, tendon degeneration, instability,and trauma comprise the multifactorial nature of rotator cuff disease. This article addresses the role of MR imaging in evaluating the rotator cuff and the importance of MR imaging in identifying other lesions that may mimic rotator cuff pathology. A rationale for protocol design, including MR arthrography and the use of specialized positioning, such as abduction and external rotation (ABER), are discussed.

Humans↗
PubMed2005

Triad of MR arthrographic findings in patients with cam-type femoroacetabular impingement.

PURPOSE: To retrospectively analyze magnetic resonance (MR) arthrographic findings in patients with clinical cam-type femoroacetabular impingement. MATERIALS AND METHODS: This study was approved by the institutional review board, and informed consent was waived. Study was compliant with the Health Insurance Portability and Accountability Act. Forty-two MR arthrograms obtained in 40 patients with clinical femoroacetabular impingement were analyzed retrospectively by two radiologists. Quantitative analysis by using alpha angle measurement was performed to assess anterosuperior femoral head-neck morphology. Presence of labral tears, articular cartilage lesions, paralabral cysts, os acetabuli, and synovial herniation pits was recorded. Presence of the typical triad of anterosuperior labral tear, anterosuperior cartilage lesion, and abnormal alpha angle was recorded. Surgical comparison was available for 11 patients. RESULTS: At imaging, in 40 patients (22 male, 18 female) with a mean age of 36.5 years, 39 of 42 hips (93%) had an abnormal alpha angle, with a mean angle of 69.7 degrees ; 40 of 42 (95%) had an anterosuperior cartilage abnormality; and 42 of 42 (100%) had an anterosuperior labral tear. Thirty-seven of 42 hips (88%) had the triad. Six had paralabral cysts, 17 had an os acetabuli, and two had synovial herniation pits. Surgical comparison for 11 hips led to confirmation of all labral and cartilage abnormalities seen at imaging. CONCLUSION: MR arthrography demonstrated a triad of abnormal head-neck morphology, anterosuperior cartilage abnormality, and anterosuperior labral abnormality in 37 of 42 patients with cam-type femoroacetabular impingement.

Acetabulum↗
PubMed2005

Synovial inflammatory processes in the hand.

The numerous synovial articulations and tendon sheaths of the hand afford it a central role in the diagnosis and management of inflammatory arthropathies. Inflammation may be idiopathic, infectious, post-traumatic, or secondary to deposition diseases. In most cases, synovial inflammation represents the primal event in the onset of destructive arthropathies. We review the imaging features of acute and chronic synovitis in the hand. Magnetic resonance imaging is very sensitive to the earliest changes of synovitis and provides a modality for early detection of disease. Additionally, once a diagnosis is established, magnetic resonance imaging has an emerging role in rapid assessment of response to therapy. Positron emission tomography and ultrasound also show promise in the evaluation and treatment of inflammatory arthropathies. Although highly sensitive to the presence of inflammation these more advanced imaging techniques often lack specificity. Therefore, the radiographic evaluation of the pattern of bone destruction remains critical to distinguishing among the different synovial inflammatory processes.

Arthritis↗
PubMed2005

MR imaging of sports-related groin pain.

With increasing participation in professional and recreational athletics, activity-limiting pelvic and groin pain presents a growing challenge for patients and health care providers. The causes of musculoskeletal-related groin pain among athletes are diverse, with considerable overlap in history and physical examination findings. Pubalgia is a clinical diagnosis invoked when no more specific cause ofa patient's symptoms can be determined on history and physical examination. In many cases, dedicated MR imaging of the hip and pelvis can provide a prompt and specific diagnosis, which allows for early treatment and return to participation.

Athletic Injuries↗
PubMed2005

Intramyocellular lipid quantification: repeatability with 1H MR spectroscopy.

PURPOSE: To prospectively determine the repeatability and variability of tibialis anterior intramyocellular lipid (IMCL) quantifications performed by using 1.5-T hydrogen 1 (1H) magnetic resonance (MR) spectroscopy in healthy subjects. MATERIALS AND METHODS: Institutional review board approval and written informed consent were obtained for this Health Insurance Portability and Accountability Act-compliant study. The authors examined the anterior tibial muscles of 27 healthy subjects aged 19-48 years (12 men, 15 women; mean age, 25 years) by using single-voxel short-echo-time point-resolved 1H MR spectroscopy. During a first visit, the subjects underwent 1H MR spectroscopy before and after being repositioned in the magnet bore, with voxels carefully placed on the basis of osseous landmarks. Measurements were repeated after a mean interval of 12 days. All spectra were fitted by using Java-based MR user interface (jMRUI) and LCModel software, and lipid peaks were scaled to the unsuppressed water peak (at 4.7 ppm) and the total creatine peak (at approximately 3.0 ppm). A one-way random-effects variance components model was used to determine intraday and intervisit coefficients of variation (CVs). A power analysis was performed to determine the detectable percentage change in lipid measurements for two subject sample sizes. RESULTS: Measurements of the IMCL methylene protons peak at a resonance of 1.3 ppm scaled to the unsuppressed water peak (IMCL(W)) that were obtained by using jMRUI software yielded the lowest CVs overall (intraday and intervisit CVs, 13.4% and 14.4%, respectively). The random-effects variance components model revealed that nonbiologic factors (equipment and repositioning) accounted for 50% of the total variability in IMCL quantifications. Power analysis for a sample size of 20 subjects revealed that changes in IMCL(W) of greater than 15% could be confidently detected between 1H MR spectroscopic measurements obtained on different days. CONCLUSION: 1H MR spectroscopy is feasible for repeatable quantification of IMCL concentrations in longitudinal studies of muscle metabolism.

Adult↗
PubMed2005

Intramuscular rotator cuff cysts: association with tendon tears on MRI and arthroscopy.

OBJECTIVE: This study was designed to explore the relationship between intramuscular cysts and rotator cuff tendon tears. CONCLUSION: Intramuscular cysts are strongly associated with rotator cuff tendon tears. Identification of such a cyst should prompt a search for a rotator cuff tear. Findings on MR arthrography and surgery suggest that a delaminating component of the rotator cuff tear may lead to the development of these cysts and may explain the occasional discrepancy between location of tears and location of cysts.

Arthroscopy↗
PubMed2004

Direct magnetic resonance arthrography.

Magnetic resonance (MR) arthrography has gained increasing popularity as a diagnostic tool in the assessment of intra-articular derangements. Its role has been studied extensively in the shoulder, but it also has been explored in the hip, elbow, knee, wrist and ankle. This article reviews the current role of direct MR arthrography in several major joints, with consideration of pertinent anatomy, techniques and applications.

Adult↗
PubMed2004

Structural analysis and optimization of NK(1) receptor antagonists through modulation of atropisomer interconversion properties.

We have previously described a series of antagonists that showed high potency and selectivity for the NK(1) receptor. However, these compounds also had the undesirable property of existing as a mixture of interconverting rotational isomers. Here we show that alteration of the 2-naphthyl substituent can modulate the rate of isomer exchange. Comparisons of the NK(1) receptor affinity for the various conformational forms has facilitated the development of a detailed NK(1) pharmacophore model.

Animals↗
PubMed2003

Accuracy of cartilage and subchondral bone spatial thickness distribution from MRI.

PURPOSE: To assess three-dimensional measurement accuracy of articular cartilage (AC) and subchondral bone (SB) thickness from MRI. MATERIALS AND METHODS: A computer program was used to calculate AC and SB thickness from MRI (three-dimensional spoiled gradient echo (SPGR),.31-mm resolution, 1-mm slice thickness) of six adult femoral heads. Specimens were imaged in five anatomical planes ranging between +30 degrees to -30 degrees from neutral and cut into 2-mm thick sections along the five anatomical planes. Faxitron x-ray was used to produce microradiographic (.05-mm resolution) images of the sections. RESULTS: In-plane measurement accuracy was.165 +/-.108 mm for AC thickness and.387 +/-.174 mm for SB thickness. Taking into account chemical-shift misregistration in SB thickness, accuracy of measurements improved to.213 +/- 128 mm. Out-of-plane (three-dimensional) thickness accuracy of the model, assessed by numerical simulation, was.015 mm. However, three-dimensional thickness errors in specimens were.319 +/-.256 mm for AC and.253 +/-.183 mm for SB thickness. CONCLUSION: Errors in three-dimensional AC thickness were attributed to volume-averaging effects caused by oblique intersection of the image plane with the joint surface. Errors in three-dimensional SB thickness were attributed to chemical-shift artifact. We conclude that accuracy of AC thickness is within clinically acceptable standards but that more sophisticated pulse sequences are needed to improve the measurement of SB thickness.

Adult↗
PubMed2003

Subchondral bone and cartilage thickness from MRI: effects of chemical-shift artifact.

Magnetic resonance imaging (MRI) is the modality of choice for visualizing and quantifying articular cartilage thickness. However, difficulties persist in MRI of subchondral bone using spoiled gradient-echo (SPGR) and other gradient-echo sequences, primarily due to the effects of chemical-shift artifact. Fat suppression techniques are often used to reduce these artifacts, but they prevent measurement of bone thickness. In this report, we assess the magnitude of chemical-shift effects (phase-cancellation and misregistration artifacts) on subchondral bone and cartilage thickness measurements in human femoral heads using a variety of pulse sequence parameters. Phase-cancellation effects were quantified by comparing measurements from in-phase images (TE=13.5 ms) to out-of-phase images (TE=15.8 ms). We also tested the assumption of the optimal in-phase TE by comparing thickness measures at small variations on TE (13.0, 13.5 and 14.0 ms). Misregistration effects were quantified by comparing measurements from water+fat images (water-only+fat-only images) to the measurements from in-phase (TE=13.5) images. A correction algorithm was developed and applied to the in-phase measurements and then compared to measurements from water+fat images. We also compared thickness measurements at different image resolutions. Results showed that both phase-cancellation artifact and misregistration artifact were significant for bone thickness measurement, but not for cartilage thickness measurement. Using an in-phase TE and correction algorithm for misregistration artifact, the errors in bone thickness relative to water+fat images were non-significant. This information may be useful for developing pulse sequences for optimal imaging of both cartilage and subchondral bone.

Adipose Tissue↗
PubMed2003

Magnetic resonance imaging of the shoulder: rotator cuff.

Magnetic resonance imaging has proven to be useful in the assessment of rotator cuff injuries. Improvements in magnetic resonance techniques, including fast spin-echo imaging and fat saturation, have facilitated demonstration of tendinous abnormalities of the rotator cuff. Rotator cuff disease is multifactorial. Primary impingement within the coracoacromial arch, degeneration of the rotator cuff tendons, trauma, and glenohumeral instability may be contributing factors. Shoulder pain in athletes can be related to acute myotendinous and muscle injuries, which can be easily detected using magnetic resonance imaging.

Athletic Injuries↗
PubMed2003

Magnetic resonance imaging of the hip: sports-related injuries.

Normal hip disorders do not account for a large proportion of exercise-related injuries, but they can pose a clinical dilemma because symptoms tend to be nonspecific. Conventional radiographs may demonstrate some causes of hip pain, such as stress fractures and degenerative joint disease. Magnetic resonance imaging (MRI) of the hip has proven valuable in the diagnosis of radiographically occult osseous abnormalities and periarticular soft-tissue disorders such as stress fractures, avulsion injuries, musculotendinous abnormalities, and bursitis. Conventional MRI has been less useful in the evaluation of intra-articular lesions, including acetabular labral tears, intra-articular loose bodies, and cartilage lesions. Visualization of intra-articular structures and their abnormalities can be improved by injection of diluted gadolinium, which distends the capsule and leaks into labral tears. This article focuses on the use of conventional radiography and MRI in recreational and professional athletes with painful hip joints. Where possible, MRI is compared with other diagnostic modalities such as bone scan and computed tomography.

Adolescent↗
PubMed2003

Magnetic resonance imaging of knee trauma: biomechanical approach.

Knee trauma often produces predictable groupings of ligamentous and meniscal injuries. Structures that perform related kinematic functions are damaged by the same traumatic mechanisms. When one supporting structure is disrupted, synergistic structures are jeopardized. Locations of meniscal tear, capsuloligamentous sprain, and osseous injury all provide clues about the mechanism of injury. By understanding the most common patterns of knee injury, a biomechanical approach can be used in the interpretation of magnetic resonance images. The identification of abnormality in one structure should lead to a directed search for subtle abnormalities involving anatomically or functionally related structures, thereby improving diagnostic confidence.

Athletic Injuries↗