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Biomedical subjects

William R Lacefield

Publications and source records attributed to William R Lacefield.

2 recordsLinked to original sources

The effect of three commonly used endodontic materials on the strength and hardness of root dentin.

The purpose of this study was to determine if calcium hydroxide, mineral trioxide aggregate, or sodium hypochlorite caused a change in the force required to fracture root dentin. Ten bovine central and lateral incisors were machined using various saws and drills to produce a cylinder of dentin with a 6.0-mm outer diameter 3.5-mm inner diameter and a length of 10 mm. The cylinders were cut lengthwise into four symmetrical pieces. The canal sides of the sections were then placed into Petri dishes containing a 1-mm depth of calcium hydroxide, mineral trioxide aggregate, sodium hypochlorite, or physiologic saline (control). The samples remained in the dishes for 5 weeks and were then shear tested by using an Instron machine. Data were analyzed using an ANOVA test for comparison of the groups as a whole, and a t test was used to compare each quarter section with its control from the same tooth. A 32% mean decrease in strength was discovered for calcium hydroxide, a 33% decrease in strength for mineral trioxide aggregate, and a 59% decrease for sodium hypochlorite. All decreases in strength were statistically significant: p < 0.001 for calcium hydroxide, p = 0.027 for mineral trioxide aggregate, and p < 0.001 for sodium hypochlorite. Results indicated that root dentin was weakened after 5 weeks of exposure to calcium hydroxide, mineral trioxide aggregate, or sodium hypochlorite.

Aluminum Compounds↗

Nanostructured ceramics for biomedical implants.

Recent progress in the synthesis, characterization, and biological compatibility of nanostructured ceramics for biomedical implants is reviewed. A major goal is to develop ceramic coating technology that can reduce the friction and wear in mating total joint replacement components, thus contributing to their significantly improved function and longer life span. Particular attention is focused on the enhancement of mechanical properties such as hardness, toughness, and friction coefficient and on the bioactivity as they pertain to the nanostructure of the material. The development of three nanostructured implant coatings is discussed: diamond, hydroxyapatite, and functionally graded metalloceramics based on the Cr-Ti-N ternary system. Nanostructured diamond produced by chemical vapor deposition (CVD) techniques and composed of nano-size diamond grains have particular promise because of the combination of ultrahigh hardness, improved toughness over conventional microcrystalline diamond, low friction, and good adhesion to titanium alloys. Nanostructured processing applied to hydroxyapatite coatings is used to achieve the desired mechanical characteristics and enhanced surface reactivity and has been found to increase osteoblast adhesion, proliferation, and mineralization. Finally, nanostructured metalloceramic coatings provide continuous variation from a nanocrystalline metallic bond at the interface to the hard ceramic bond on the surface and have the ability to overcome adhesion problems associated with ceramic hard coatings on metallic substrates.

Animals↗