Biomedical subjects

William Saunders

Publications and source records attributed to William Saunders.

5 recordsLinked to original sources

PubMed2006

Cost and utilization of blood transfusion associated with spinal surgeries in the United States.

The purpose of this study was to examine factors associated with the utilization and cost of blood transfusion during and post-spinal fusion surgery. A retrospective, observational study of 42,029 inpatients undergoing spinal fusion surgery in United States hospitals participating in the Perspective( Comparative Database for inpatient use was conducted. Descriptive analysis, logistic regression, and ordinary least squares (OLS) regression were used to describe the factors associated with the use and cost of allogeneic blood transfusion (ABT). Hospitalization costs were $18,690 (SD=14,159) per patient, erythropoietin costs were $85.25 (SD=3,691.66) per patient, and topical sealant costs were $414.34 (SD=1,020.06) per patient. Sub-analysis of ABT restricted to users revealed ABT costs ranged from $312.24 (SD=543.35) per patient with whole blood to $2,520 (SD=3,033.49) per patient with fresh frozen plasma. Patients that received hypotensive anesthesia (OR,1.61; 95% CI, 1.47-1.77), a volume expander (OR,1.95; 95% CI, 1.75-2.18), autologous blood (OR, 2.04; 95% CI, 1.71-2.42), or an erythropoietic agent (OR=1.64; 95% CI, 1.27-2.12) had a higher risk of ABT. Patients that received cell salvage had a lower risk of transfusion (OR=0.40; 95% CI, 0.32-0.50). Most blood avoidance techniques have low utilization or do not reduce the burden of transfusion associated with spinal fusion.

Adult↗

PubMed2005

Centrosomal amplification and spindle multipolarity in cancer cells.

Recent developments have highlighted the important role centrosomal defects play in the cellular changes associated with tumorigenesis. This article reviews recent developments addressing the impact of numerical centrosomal amplification on chromosomal segregational defects in the cancer cell. Probably, the most significant is the change to the structure of the spindle that leads to increased numbers of spindle poles and abnormal partitioning of the chromosomes in mitosis. I address how centrosomal changes are initiated and how they may lead to spindle multipolarity.

Centrosome↗

PubMed2004

Washington insider.

Explore the source record for details and available documents.

Abortion, Induced↗

PubMedDate not supplied

Resource utilization and costs of blood management services associated with knee and hip surgeries in US hospitals.

This article assesses the use and costs of blood transfusion during knee and hip surgery through a retrospective observational study of 92,223 discharged inpatients who had undergone knee or hip surgery from July 1, 2003, through June 30, 2004; a sample of US hospitals that participated in the Perspective Comparative Database (Premier Inc., Charlotte, NC) was used. Descriptive and multivariate analyses were performed to determine the use and costs of allogeneic blood transfusion (ABT). The average cost of ABT per user ranged from $387 (SD=$952) for red blood cells to $6585 (SD=$11,162) for cryoprecipitate. Utilization rates in the sample were as follows: antifibrinolytics, 0.14%; topical sealants, 3.24%; volume expanders, 3.89%; erythropoietin agents, 5.08%; and hypotensive anesthesia, 22.28%. Patients who were given volume expanders ($133.73, SD=$23.00, P<.01) or erythropoietin ($177.72, SD=$34.61, P<.01) had higher costs associated with ABT than did those who did not use volume expanders or erythropoietin. Patients who received hypotensive anesthesia (odds ratio [OR]=1.96; 95% confidence interval [CI], 1.87-2.06), a volume expander (OR=1.71; 95% CI, 1.57- 1.85), a topical sealant (OR=1.61; 95% CI, 1.45-1.79), or an erythropoietic agent (OR=2.30; 95% CI, 2.06-2.57) had a greater likelihood of ABT. Investigators concluded that most transfusion reduction techniques are underused, or they do not reduce the burden of ABT associated with knee or hip surgery.

Aged↗

PubMedDate not supplied

Bridging mitotic defects and clinical diagnoses.

Anaphase bridges are known to play important roles in generating the genetic instability of cancer cells. Now anaphase bridges are shown to be a candidate for a new diagnostic tool to distinguish between chromosomally stable and unstable tumors. These results emphasize the importance of mitotic defects to cancer and begin to translate our understanding of mitotic errors in tumor cells into tools the clinician can use.

Anaphase↗