Biomedical subjects

Wladimir Solodenko

Publications and source records attributed to Wladimir Solodenko.

5 recordsLinked to original sources

PubMed2006

Combining enabling techniques in organic synthesis: continuous flow processes with heterogenized catalysts.

The concepts article describes enabling techniques (solid-phase assisted synthesis, new reactor design, microwave irradiation and new solvents) in organic chemistry and emphasizes the combination of several of them for creating new synthetic technology platforms. Particular focus is put on the combination of immobilized catalysts as well as biocatalysts with continuous flow processes. In this context, the PASSflow continuous flow technique fulfils both chemical as well as chemical engineering requirements. It combines reactor design with optimized, monolithic solid phases as well as reversible immobilization techniques for performing small as well as large scale synthesis with heterogenized catalysts under continuous flow conditions.

Journal Article↗

PubMed2005

2-Pyridinealdoxime, a new ligand for a Pd-precatalyst: application in solid-phase-assisted Suzuki-Miyaura reaction.

The preparation of a new palladium(II) complex with a 2-pyridinealdoxime ligand and its use as a Pd(0) precatalyst in the cross-coupling Suzuki-Miyaura reaction is described. Several concepts for the immobilization of this catalytic system are presented and compared in order to develop an efficient catalytic tool for high-throughput synthesis.

Boronic Acids↗

PubMed2003

Polymer/carrier composites as materials and reactors for organic synthesis.

In this work new polymer/carrier composites are described which serve as novel materials in flow-through reactors for polymer-supported organic solution-phase synthesis. Monolithic polymer/carrier columns are prepared by a new precipitation polymerization process inside the void pore volume of megaporous glass carrier materials. Chemical functionalization of the internal polymer phase with chlorosulfonic acid or trimethylamine generates small, interconnected ion-exchange resin beads with a diameter of 1-3 microm which can be used for a large variety of organic syntheses. These monolithic rods are incorporated into an appropriate casing and can conveniently be operated in the flow-through mode. Important successful applications are polymer-assisted solution-phase reductions, oxidations and Horner-Emmons olefinations. Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described.

Catalysis↗

PubMed2002

Polymer-assisted Horner-Emmons olefination using PASSflow reactors: pure products without purification.

A PASSflow protocol for the Horner-Emmons olefination of aldehydes using polymer-bound hydroxide ions in flowthrough reactors is presented which allows preparation of alkenes in very high yield with minimal purification.

Aldehydes↗

PubMed2001

PASSflow Syntheses Using Functionalized Monolithic Polymer/Glass Composites in Flow-Through Microreactors Part of these studies were supported by the Fonds der Chemischen Industrie and the European Community (EC project number HPRI-CT-1999-00085) for which we are grateful. PASSflow=Polymer Assisted Solution-Phase Synthesis technique in flow-through mode.

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Journal Article↗