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Biomedical subjects

Wm Drew Gouvier

Publications and source records attributed to Wm Drew Gouvier.

14 recordsLinked to original sources
PubMed2006

The conviction of delusional beliefs scale: reliability and validity.

This study reports on the development of a new measure of delusional belief conviction, the Conviction of Delusional Beliefs Scale (CDBS). Most of the current scales in use assess belief conviction with a single item and primarily reflect the cognitive aspects of conviction. The CDBS represents an improvement over existing scales in that it contains a larger number of test items that can be subjected to psychometric examination. In addition, the CDBS also broadens the concept of belief conviction by incorporating cognitive, emotional, and behavioral items. In the present study, fifty participants with delusions completed the CDBS along with measures of delusional ideation, psychiatric symptomatology, insight, and reading ability. The CDBS showed very good levels of internal consistency and test-retest stability over a six-week period. All of the CDBS items loaded highly on a unitary factor of belief conviction. The CDBS positively correlated with four measures of belief conviction thereby reflecting the convergent validity of the scale. The CDBS was unrelated to other dimensions of delusional ideation, psychiatric symptomatology, insight, and reading ability, which supported the discriminant validity of the scale. The CDBS appears to be a reliable and valid measure of delusional belief conviction that could be used in clinical and research settings.

Adult↗
PubMed2006

Information processing following mild head injury.

Research has shown that individuals who have sustained mild head injury demonstrate a slowed speed of processing that is exacerbated by fatigue/stress. We administered the Paced Auditory Serial Addition Test (PASAT) at the beginning and at the end of a 4-h experimental protocol to determine whether fatigue or a stressor would result in poorer scores for individuals who had previously sustained mild head injury. A significant improvement was found between the first and second administration for both head-injured and control subjects, but difference scores revealed a significant between-groups difference for the first of the four trials, with the head-injured participants performing worse than controls. Apparently, head-injured participants were slower to develop, as well as slower to regain, a means of efficiently processing rapidly presented information.

Adolescent↗
PubMed2006

Complex partial seizure symptom endorsement in individuals with a history of head injury.

Research has shown that subjects at risk for cerebral dysfunction endorse more complex partial seizure symptoms than low risk controls. It has been suggested that seizure activity be regarded as occurring on a continuum of neurobehavioral dysfunction, rather than as a discrete syndrome. The present study assessed seizure symptom endorsement in individuals reporting a positive history of head injury. There were three groups of college student participants: head injury with loss of consciousness (LOC; n=31); head injury followed by a dazed period or alteration of consciousness (AOC; n=36); non-injured controls (NHI; n=60). In general, the LOC group reported greater frequency of symptomatology and a greater number of clinically significant symptoms (above the 90th percentile) than the NHI group, and a greater number of clinically significant symptoms than the AOC group. The AOC group did not differ from the NHI group on either variable. These results lend credence to the concept of a continuum representing an epilepsy spectrum disorder.

Adolescent↗
PubMed2006

Are we honestly studying malingering? A profile and comparison of simulated and suspected malingerers.

Malingering research typically uses analog simulation design or differential prevalence design among "real" patients. Both have been criticized for methodological limitations in external and internal validity, respectively. Samples of simulated malingerers were compared to suspected malingerers to examine generalizability of analog findings. Overall results support the use of simulation designs. Furthermore, it was demonstrated that stringent selection of suspected malingerers maintains internal validity of the differential prevalence design. A second focus, to determine if demographic matching of simulated malingerers is necessary, showed that matching on age and race is not necessary.

Achievement↗
PubMed2005

Informed consent in schizophrenia: the use of cues in the assessment of understanding.

The purpose of this study was to determine if providing cues could facilitate participant understanding for consent form information. Understanding scores were measured in a group of participants diagnosed with schizophrenia and a control group using cued recognition and uncued recall methods. When understanding was measured with uncued methods, persons with schizophrenia showed lower scores compared to the control group. However, when cues were provided, there was no difference between the two groups on understanding scores, and persons with schizophrenia showed normal levels of understanding. The results suggest that cued methods may be a better alternative to measure participant understanding.

Adolescent↗
PubMed2005

Detecting simulated memory impairment: further validation of the Word Completion Memory Test (WCMT).

The Word Completion Memory Test (WCMT) was developed to detect sophisticated attempts at simulating memory impairment. The primary purpose of the present study was to provide additional validity and reliability information about the WCMT. Seventy-one participants were recruited for this study: 30 normal volunteers and 11 memory-disordered patients instructed to perform their best, and 30 normal volunteers instructed to fake memory impairment. Normal volunteers were administered five tests of neuropsychological functioning and five tests of simulation to explore the convergent and divergent validity of the WCMT. Two weeks later, these participants completed all 10 measures a second time. Memory-disordered patients were administered the WCMT and two additional simulation measures as part of a comprehensive neuropsychological evaluation. The WCMT successfully discriminated simulators from nonsimulators with an overall classification accuracy of 97% and demonstrated good psychometric properties. In conclusion, the WCMT continues to show promise as a measure of simulated memory impairment.

Adolescent↗
PubMed2005

Utility of the UFOV test with mild traumatic brain injury.

Driving skills are socially important, easily disrupted by brain injury, and potentially risky and difficult to evaluate afterward. The Useful Field of View test has seen successful use with severe traumatic brain injury (TBI), but its use with mild TBI victims has not been examined. This study shows its ecological insensitivity among persons with mild TBI or no impairment and suggests its use be limited to more severely impaired persons.

Adolescent↗
PubMed2004

Neuropsychological and emotional changes during simulated microgravity: effects of triiodothyronine alendronate, and testosterone.

INTRODUCTION: We present the results of a two-experiment study designed to evaluate the neurocognitive and psychological effects of six-degree head-down bedrest and pharmacologic interventions (3,5,3'-triiodothyronine; T3) implemented to enhance the muscle and bone atrophy associated with simulated microgravity. Subsequently, the effects of countermeasures (alendronate and testosterone) administered to retard or reverse these T3 plus bedrest enhanced atrophic changes, were evaluated. Each participant was tested weekly for 5 weeks during Bedrest or non-bedrest (Up) conditions with the Neurobehavioral Evaluation System 2 (NES2), the Symptom Check List 90 Revised (SCL-90-R), and the Coping Responses Inventory (CRI). Resultant data were subjected to repeated measures, between groups analysis of variance testing for all 82 neurocognitive and psychological test measures. RESULTS: In Experiment 1, participants in the Placebo-Bedrest condition performed better on several neurocognitive measures compared to participants in the T3-Up condition. However, participants in the Placebo-Bedrest condition also reported more confusion. In Experiment 2 (countermeasure trials), superior coordination was observed for participants in the Testosterone-T3 condition over those in the Alendronate-T3 condition, but just the opposite for reaction time. Also, testosterone and to a lesser degree, alendronate, were associated with less self-reported emotional distress than T3 plus bedrest alone. CONCLUSION: Triiodothyronine, alendronate, and testosterone each influence participant response to simulated microgravity. Between group differences for significant findings were substantial and averaged 1.62 standard deviations. Although the observed neurocognitive effects likely pose no immediate danger for research participants, the significantly greater level of self-reported psychological symptoms by T3-Placebo and Placebo-Bedrest treated participants is of clinical importance.

Adult↗
PubMed2004

The role of attention in affect perception: an examination of Mirsky's four factor model of attention in chronic schizophrenia.

Attentional skills among people with schizophrenia may be related to deficits in affect perception. Such deficits can dramatically inhibit appropriate social functioning. We examined attention and affect perception in a sample of 65 people diagnosed with chronic schizophrenia. We used Mirsky's four factor model of attention to assess attentional functioning. To measure affect perception, we used two reliable measures of emotion recognition, the Bell-Lysaker Emotion Recognition Test and the Face Emotion Identification Test. Multiple regression analysis showed that all four attentional factors and a diagnosis of paranoid schizophrenia were significantly predictive of affect perception scores. In contrast, psychiatric symptoms, medication levels, demographic variables, verbal fluency, and face recognition scores were not predictive of affect perception scores. The four factors of attention accounted for 78 percent of the variance in affect perception scores. These results emphasize the role that attentional abilities play in affect perception for people with schizophrenia.

Adult↗
PubMed2004

Sensation seeking and risk behaviors in young adults with and without a history of head injury.

Research has demonstrated a relation between sensation seeking and risky behavior as well as an association between risky behavior and the occurrence of head injury. This study assessed sensation seeking in young adults with and without a history of head injury by administration of the Sensation Seeking Scale (SSS), the Driver Risk Index (DRI), and the MacAndrews Scale of the Minnesota Multiphasic Personality Inventory (MMPI). There was a significant difference between the groups for the Thrill and Adventure Seeking Subscale of the SSS and the MacAndrews Scale of the MMPI, with head-injured participants scoring higher. Gender differences were seen in both groups for subscales of the SSS, with men scoring higher. Significant correlations were found for head-injured participants between the DRI and the Boredom Susceptiblity Subscale of the SSS, suggesting that as knowledge of risk increased for these participants, so did their preferences for risky behaviors. However, non-head-injured participants indicated a lower interest in risky behaviors as their knowledge of risk increased.

Adult↗
PubMed2003

The Recognition Memory Test Examination of ethnic differences and norm validity.

The possibility of racial bias in neuropsychological test materials has received increasing attention in recent years. The purpose of the present study was to investigate whether an own-race recognition bias would provide an advantage for Caucasian participants over African American participants on the Faces subtest of the Recognition Memory Test (RMT). Thirty Caucasian and 30 African American undergraduates completed the RMT, Shipley Institute of Living Scale (SILS), and Symbol Digit Modalities Test (SDMT). No significant group difference was found on RMT Faces. However, mean RMT Faces scores for both groups were below the 10th percentile in spite of average scores on the SDMT and SILS. A second study was conducted to further examine the validity of the RMT norms for this age range (i.e., 18-24) and to provide 2-week test-retest reliabilities. The mean RMT Faces subtest score was 39.78 (10th percentile), and 28% of the sample scored at or below the fifth percentile. Test-retest reliabilities were.63 and.64 for RMT Words and Faces, respectively. Results of these studies suggest that re-examination of the current norms for RMT Faces is warranted for adults aged.

Adolescent↗
PubMed2003

Partial cross-validation of the Wechsler Memory Scale-Revised (WMS-R) General Memory-Attention/Concentration Malingering Index in a nonlitigating sample.

The Wechsler Memory Scale-Revised (WMS-R) malingering indices proposed by Mittenberg, Azrin, Millsaps, and Heilbronner [Psychol Assess 5 (1993) 34.] were partially cross-validated in a sample of 200 nonlitigants. Nine diagnostic categories were examined, including participants with traumatic brain injury (TBI), brain tumor, stroke/vascular, senile dementia of the Alzheimer's type (SDAT), epilepsy, depression/anxiety, medical problems, and no diagnosis. Results showed that the discriminant function using WMS-R subtests misclassified only 6.5% of the sample as malingering, with significantly higher misclassification rates of SDAT and stroke/vascular groups. The General Memory Index-Attention/Concentration Index (GMI-ACI) difference score misclassified only 8.5% of the sample as malingering when a difference score of greater than 25 points was used as the cutoff criterion. No diagnostic group was significantly more likely to be misclassified. Results support the utility of the GMI-ACI difference score, as well as the WMS-R subtest discriminant function score, in detecting malingering.

Adult↗
PubMed2002

The role of temporal lobe and orbitofrontal cortices in olfactory memory function.

Differences in verbal and nonverbal olfactory identification and recognition were examined among three groups with brain impairment. A left cerebrovascular accident (LCVA) group, a right CVA (RCVA) group, and a traumatic brain injury (TBI) group were compared with two nonimpaired age-matched comparison groups on olfaction identification and recognition abilities. Odors were presented to the left and right nostrils, which maximized hemispheric differences in olfactory processing. Results showed that persons with LCVA demonstrated the greatest impairment on the verbal identification of odors, while persons with RCVA showed the most impairment on the nonverbal identification of odors. Persons with TBI showed an inconsistent impairment across both verbal and nonverbal odor identification tasks. Odor recognition was impaired in both CVA groups as well. In contrast, persons with TBI performed better on the delayed odor recognition tasks. Results are discussed in relation to hemispheric differences in processing olfactory information.

Journal Article↗