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Won Jae Yang

Publications and source records attributed to Won Jae Yang.

6 recordsLinked to original sources
PubMed2006

Detection rate of prostate cancer on biopsy according to serum prostate-specific antigen in Korean men: a multicenter study.

OBJECTIVES: To evaluate the detection rate of prostate cancer on biopsy according to the serum prostate-specific antigen (PSA) level in Korean men and compare the detection rate with those of Japanese and American men in other studies. METHODS: We retrospectively analyzed 2422 Korean men who had undergone prostate biopsy at 12 medical centers from 1993 to 2002. In the case of a PSA level greater than 4.0 ng/mL or abnormal digital rectal examination findings, prostate biopsy was performed. RESULTS: Of the 2422 men, 962 (39.7%) were diagnosed with prostate cancer. With PSA levels between 4.0 and 10.0 ng/mL, the detection rate of prostate cancer was 15.9%. This rate was similar to that of Japanese men (15.8%), but lower than that of American men (25%). In the cases with a PSA level greater than 10.0 ng/mL, the detection rate for Korean and Japanese men was 59.5%, and was also lower than the 67% rate for American men. When serum PSA levels were divided into five subgroups (less than 4.0, 4.0 to 10.0, 10.0 to 20.0, 20.0 to 100.0, and greater than 100.0 ng/mL), the detection rate of prostate cancer was 12.4%, 15.9%, 34.1%, 66.2%, and 93.8%, respectively. CONCLUSIONS: In Korean men, the detection rate of prostate cancer on biopsy according to serum PSA level appears to be comparable to that for Japanese men and lower than that for American men.

Adult↗
PubMed2006

Long-term effects of ileal conduit urinary diversion on upper urinary tract in bladder cancer.

OBJECTIVES: To evaluate the functional and morphologic changes of the upper urinary tract after radical cystectomy and ileal conduit urinary diversion for bladder cancer. METHODS: Radical cystectomy and ileal conduit urinary diversion were performed in a total of 249 patients with bladder cancer at our hospital from 1980 to 1999. Of the 249 patients, 67 were excluded because of the presence of preoperative lesions in the upper urinary tract or elevated serum creatinine (greater than 1.4 mg/dL). Of the remaining 182 patients, 82 were also excluded because of incomplete follow-up or death less than 5 years after surgery. RESULTS: Of the 249 patients, a total of 100 (40.2%) who had no preoperative lesions in upper urinary tract and normal renal function and survived 5 years or longer were included in this analysis. The median follow-up period was 91 months (range 60 to 193). The serum creatinine was greater than the normal range in 10 patients (10.0%), and radiologic changes in the upper urinary tract were observed in 14 patients (14.0%). They had diabetes mellitus nephropathy (4.0%) or specific comorbidities that could contribute to the deterioration of the upper urinary tract, such as ureteroileal anastomotic stricture (4.0%), chronic pyelonephritis (4.0%), urinary stones (1.0%), and upper urinary tract tumor (1.0%). CONCLUSIONS: The results of our study have shown that the functional and morphologic changes in the upper urinary tract after radical cystectomy and ileal conduit urinary diversion occur in patients with specific comorbidities that could contribute to those changes. Different from previous reports, none of the upper urinary tract changes developed without an obvious cause.

Adult↗
PubMed2005

Extramammary Paget's disease of penis and scrotum.

OBJECTIVES: To make clear the uncertainty of the clinical outcome of extramammary Paget's disease (EMPD). Penile and scrotal involvement of EMPD is exceedingly rare, and only small series or case reports have been reported. METHODS: From 1995 to 2003, 36 patients with penile and scrotal EMPD were treated and followed up. Local wide excision was done in all patients with or without intraoperative frozen biopsy analysis. RESULTS: Of the 36 patients, 13 (36.1%) underwent intraoperative frozen biopsy analysis and only 1 patient (7.7%) had a positive surgical margin. However, 23 (63.9%) underwent local wide excision with excessive surgical margins of up to 1 to 2 cm only by gross examination, but 17 (73.9%) of them had positive surgical margins (P <0.01). Of the 17 patients with positive surgical margins, 8 developed local recurrence at a median of 8 months of follow-up (P <0.05). One patient who had invasion to the subcutaneous tissue died of metastatic EMPD and internal malignancy (renal cell carcinoma) at 17 months after the initial operation. No patient had underlying adnexal carcinoma. CONCLUSIONS: The results of our study indicate that local wide excision with intraoperative frozen biopsy analysis is essential to the complete treatment of EMPD.

Aged↗
PubMed2005

Vesicoureteral reflux in adult women with uncomplicated acute pyelonephritis.

OBJECTIVES: To evaluate the significance of vesicoureteral reflux (VUR) in adult women with uncomplicated acute pyelonephritis. METHODS: Eighty-six adult women with uncomplicated acute pyelonephritis were studied from April 1998 to October 2003. They showed no structural urinary tract abnormalities. The mean age of patients was 36.2 years (range, 19 to 54 years). We divided these patients into two groups. In group I (31 patients), we performed a voiding cystourethrogram (VCUG) on the third day of treatment to demonstrate possible transient low-grade VUR during the acute infectious phase. In group II (the remaining 55 patients), we performed VCUG after the seventh day of treatment. RESULTS: There were only 2 (2.3%) cases of VUR among 86 patients with uncomplicated acute pyelonephritis. No VUR was found in group I, and grade II reflux was found in 2 patients of group II. CONCLUSIONS: These results indicate that, unlike in children, VUR is not a significant factor causing ascending infection leading to the development of acute pyelonephritis in adult women. Further research is warranted regarding the pathophysiology of ascending infection in the adult population.

Acute Disease↗
PubMed2005

Juvenile prostatic hyperplasia.

Benign prostatic hyperplasia is common in aging men, but rare in childhood. We report a case of juvenile prostatic hyperplasia in a 10-year-old boy, who visited our clinic for hematuria and voiding symptoms. Radiologic studies revealed a huge prostate protruding into the bladder. The prostate was 33 g. The prostate biopsy showed no evidence of cancer. At 13 years of age, he was seen again because of general weakness, fever, and voiding difficulty. Bilateral hydroureteronephrosis was found on radiologic studies, and his serum creatinine was elevated. The prostate was 55 g. Suprapubic prostatectomy was performed.

Age Factors↗