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X Chardonnens

Publications and source records attributed to X Chardonnens.

3 recordsLinked to original sources
PubMed1979

A screening program for anti-DR typing reagents.

A total of 694 sera have been tested in a screening program aimed at identifying monospecific reagents for HLA--DR typing. All sera were first tested on a panel of enriched B and T cells without absorption on platelets. Only sera reacting more frequently on B than on T lymphocytes were absorbed on platelets and retested on the panel. This procedure saved a considerable amount of platelets and proved to be reasonably efficient. One-hundred-and-fifty sera were found to contain an anti-B cell antibody. Significantly less frequent B cell reactivity was found when HLA--A, --B, --C antibodies could not be detected. Twenty-five sera were demonstrated to be specific for well-defined DR antigens.

Antibodies, Anti-Idiotypic↗
PubMed1977

[HL-A D antigens from B-lymphocytes and susceptibility to certain diseases].

The discovery of many associations between HLA and human diseases has emphasized the biologic importance of the main histocompatibility system in man. The recent findings from specific immune response genes (Ir locus) mapping within the H2 region of the mouse have led to systematic study of the similar D locus mapping within the HLA region in man. In this study the frequency of a number of HLA-D antigens has been determined in normal individuals and in patients with four diseases selected in view of their genetic background: juvenile diabetes, multiple sclerosis, grass pollinosis and acute leukemia. In each a significant association has been found with a specific HLA-D antigen: DW3 in juvenile diabetes and grass pollinosis, DW2 in multiple sclerosis, and DW7 in acute lymphoblastic leukemia.

B-Lymphocytes↗