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Biomedical subjects

X K Huang

Publications and source records attributed to X K Huang.

9 recordsLinked to original sources
PubMed2003

The effects of the farnesyl transferase inhibitor FTI L-778,123 on normal, myelodysplastic, and myeloid leukemia bone marrow progenitor proliferation in vitro.

The effects of the farnesyl transferase inhibitor FTI-778,123 on the proliferation of normal, MDS, AML, and CML hemopoietic progenitor cells was studied. MDS myeloid and erythroid progenitors are significantly more sensitive to FTI than normal progenitors while AML myeloid progenitors may be somewhat more sensitive than normal progenitors. In contrast, no difference between CML and normal progenitors are detectable. These data strongly suggest that a trial of this agent in patients with MDS and perhaps in patients with AML is indicated.

Alkyl and Aryl Transferases↗
PubMed2000

Effects of cytokines on CD20 antigen expression on tumor cells from patients with chronic lymphocytic leukemia.

Anti-CD20 antibody is an established treatment for low-grade non-Hodgkin's lymphoma (NHL). Augmenting the expression of CD20 antigen on the tumor cells may increase the cell kill and therefore increase the effectiveness of the antibody. To study this, we incubated peripheral blood lymphocytes from CLL patients with the following cytokines: EPO, SCF, TNFalpha, TGFbeta, GMCSF, TPO, IL-1, IL-2, IL-3, IL-4, GCSF. CD20 expression was studied by flow cytometry at baseline, 24 and 72 h after exposure to these cytokines. Upregulation of CD20 antigen expression was observed with IL-4, TNFalpha and GMCSF.

Antigens, CD20↗
PubMed2000

[Influence of chronic sinusitis on middle ear function].

OBJECTIVE: To study the effect of range size and duration of chronic sinusitis on middle ear function. METHOD: Eustachian tube function, tympanogram and air hearing threshold were measured with an acoustic impedance audiometer and pure tone audiometer in 56 patients (112 ears). RESULT: Eustachian tube function was disturbed in 48.3% cases, tympanogram was abnormal in 42.0% cases, and air hearing threshold was increased in 33.9% cases. Comparison of middle ear function between anterior sinusitis and pan-sinusitis showed significant difference (P < 0.01), middle ear function between the course of less 5 years and of more than 5 years had significant difference (P < 0.05). CONCLUSION: The damage of middle ear function become more serious with the extent of lesion and with the longer course of disease in paranasal sinuses.

Acoustic Impedance Tests↗
PubMed2000

[Bacteriological analysis of chronic sinusitis in school-age children (36 cases report)].

OBJECTIVE: To research the bacteriological characters of chronic sinusitis in school-age children and to provide basis for clinical treatment. METHOD: The purrent discharges taken from middle meatus of 36 patients were cultured for bacteria and the antimicrobial suscepility was determined. RESULT: The positive rate of bacteria culture was 83.3%, the compound infection rate was 36.1%. Aerobic bacteria were present in 76.7%, anaerobic bacteria were present in 55.6%. The result of antimicrobial susceptibility test was scattered. CONCLUSION: Infection rate of anaerobic bacteria was high in chronic sinusitis in school-age children and result of antimicrobial susceptibility was scattered. It was important to have anti-anaerobic treatment in chronic sinusitis in school-age children and to take an antimicrobial susceptibility test before medical treatment.

Adolescent↗
PubMed1993

[Effects of intra-operative colonic irrigation on colonic flora in patients with intestinal obstruction caused by left colonic carcinomas].

We studied the effects of intra-operative colonic irrigation on intestinal bacteria in patients with carcinomatous obstruction of the left colon. The results showed: The floral volume of aerobes and anaerobes in colonic content and mucosa in obstructive patients increased significantly (P < 0.01), but it was reduced obviously by intra-operative colonic irrigation (P < 0.01), reaching the level of that as in the nonobstructive patients who received oral antibiotics and mechanical intestinal preparation.

Colon↗
PubMed1989

Specific antitumor immunologic reactivity in patients with retinoblastoma.

Retinoblastoma antigen (RbAg) and retinal tissue antigen (RAg) were made from allogeneic retinoblastoma tissues and normal retinal tissue using the 3M KCl method. We have examined leukocyte migration inhibition test (LMIT) and enzyme-linked immunosorbent assay (ELISA) to RbAg and RAg in normal controls and the patients with retinoblastoma, including two spontaneously regressed cases. In LMIT, six out of the 11 patients tested against RhAg showed positive reactivity, in which 4 cases reacted only with RbAg, but not with RAg. All nine control subjects had negative reactivity to the two antigens. In ELISA, 40% of the retinoblastoma patients and 5.56% in normal controls showed positive reaction against RbAg. It was suggested that not only retinal antigens but also retinoblastoma specific antigens present in human retinoblastoma cells. The results also suggested that patients with retinoblastoma and those with spontaneous regression of Rb had both cell-mediated immunologic reactivity and humoral immune response toward retinoblastoma antigen in vitro. These immune responses to RbAg may be responsible for spontaneous regression of retinoblastoma.

Adult↗
PubMed1989

Humoral and cellular immune responses to lens protein in patients with congenital cataract.

In order to understand the immune responses to lens protein in patients with congenital cataract, the passive hemagglutination assay for humoral immunity and the leukocyte migration test for cellular immunity to lens protein were performed on 43 patients with congenital cataract and 30 healthy persons served as control. The results showed that there was no significant difference in the incidence of humoral immune responses to lens protein between patients with congenital cataract and the controls (P greater than 0.05), but the incidence of cellular immune responses to lens protein in patients with congenital cataract was higher than that of the controls (P less than 0.005). The results of this study suggested that during the development of congenital cataract, lens protein leaked into the aqueous humour and entered the systemic circulation, sensitizing lymphocytes and producing cellular mediated immune responses. Further investigation is necessary to determine whether there is any relationship between the immune responses to lens protein and the formation of congenital cataract.

Adolescent↗