Biomedical subjects

X L Chu

Publications and source records attributed to X L Chu.

7 recordsLinked to original sources

PubMed2001

[Model transfer in multivariate calibration].

This paper introduces the backgrounds, principles and some popular algorithms used for resolving calibration transfer in multivariate calibration of chemometrics. The algorithms include S/B, DS, PDS, FIR, and Shenk's algorithm. The recent development of calibration transfer in the past two years is also reviewed. A number of key applications of different calibration transfer algorithms are summarized, which will be helpful for the further research of calibration transfer principles and algorithms. 51 references are cited.

Algorithms↗

PubMed1999

[Preventive effect of endothelin-1 mRNA antisense oligonucleotide on acute myocardial ischemic arrhythmia in rats].

Acute myocardial ischemia was induced by occlusion of the anterior descending of left coronary artery (LAD) in rats; the resultant arrhythmia in 1 h after LAD occlusion was evaluated. In order to prevent expression of endothelin-1 mRNA, human endothelin-1 mRNA antisense oligonucleotide (ET-1 AS-ODN) was intravenously injected 2 h before LAD occlusion. The effect of AS-ODN on plasma ET-1 concentration and the acute ischemic arrhythmia were observed. The results showed that plasma ET-1 was significantly decreased in rats pretreated with AS-ODN, and both the incidence and severity of the acute ischemic arrhythmia were decreased dose-dependently as compared with normal saline control and sense oligonucleotide control, indicating that ET-1 AS-ODN could prevent acute myocardial ischemic arrhythmia and that endogenous endothelin-1 may play an important role in the development of acute ischemic arrhythmia in rats.

Animals↗

PubMed1994

[Identification of Euphorbia humifusa Wind, and E. maculata Raf. from its confused species E. thymifolia L].

Explore the source record for details and available documents.

Plants, Medicinal↗

PubMed1991

[The application of alpha-globin-3'HVR probe for DNA fingerprinting in forensic science].

Using alpha-globin-3'HVR as the molecular hybridization probe, A clear and readable DNA fingerprint has been obtained. Based on the DNA fingerprint analysis of 200 unrelated individuals living in Beijing area, the probability of chance association of two random individuals was 4.0 x 10(-12). The study of 32 related individuals of 6 families showed that the inheritance of DNA fingerprint bands conformed to the Mendelian law. The method is reliable for the individual identification and paternity test. It provides a scientific basis for solving cases such as rape, homicide etc. and it has been used in our actual case work.

DNA Fingerprinting↗

PubMed1989

[Researches on the forensic application of DNA probe. I. The determination of paternity and the identification of individual using PYNH24 probe].

Restriction fragment length polymorphism of genomic DNA digested with MspI was analyzed using specific probe PYNH 24. The clear and readable patterns were obtained. Of 190 unrelated individuals tested, the polymorphism is 95%. Inheritance of alleles in 45 related individuals of 8 families is consistent with Mendelian Law.

DNA Probes↗

PubMed1988

The effects of high iodine on the brain development of mice.

C57 mice were divided into two groups: (A): experiment group (H group). Each female mouse was injected with 20 microliter iodized oil; (B): control group (N group). Both groups were mated 8 days after iodized oil injection. Urine iodine contents/24 h of H group was 20 times higher than that in N group 7 days after injection and 18 times higher two months later. Serum T4 values were determined. Brain protein, DNA, body weight, motility and learning ability were measured in the progeny. The results indicate that there was no statistically significant difference between the groups in any of the parameters mentioned above. This strongly suggests that a high iodine dose, given as iodized oil, does not have obvious damaging effects on brain development, at least in mice.

Animals↗

PubMed1985

[Effect of microwave contraception on human serum testosterone and luteinizing hormone].

Using home-made match kits and radioimmunoassay, both serum luteinizing hormone (LH) and testosterone (T) were measured in 53 healthy adult males using microwave contraception and 76 normal fertility males as control. The results showed that in contraceptive group the serum T level was significantly decreased (p 0.0001), while serum LH was apparently elevated (p 0.01) as compared whith the normal controls. Furthermore, the longer exposure duration the lower serum T declined and the higher serum LH increased (p 0.001). The present study suggests that the microwave dose used for contraception seems to cause damage in Leydig cell function in terms of T production, and then influence endocrine function of testis. The progressively increased LH level also indicates certain degree damage of the Leydig cells. However, the damage might be reversible. The results may be useful for further clinical investigation.

Androgens↗