PubMed Health⌕ Search

Biomedical subjects

X Leroy

Publications and source records attributed to X Leroy.

14 recordsLinked to original sources
PubMed1997

Effects of N omega-nitro-L-arginine methyl ester on the endotoxin-induced disseminated intravascular coagulation in porcine septic shock.

OBJECTIVES: Nitric oxide is known to prevent platelet aggregation and clot formation. Inhibitors of nitric oxide synthase might promote or enhance endotoxin disseminated intravascular coagulation. The present study was designed to evaluate the effects of the arginine analog, N omega-nitro-L-arginine methyl ester (L-NAME), on the endotoxin-induced disseminated intravascular coagulation in a porcine model of septic shock. DESIGN: Prospective, comparative, experimental study. SETTING: Laboratory at a large university hospital. SUBJECTS: Sixteen female piglets, weighing 20 to 28 kg. INTERVENTIONS: Three groups of animals were studied: a control group (n = 6); a lipopolysaccharide (LPS)-treated group (n = 5) receiving Escherichia coli endotoxin (5 micrograms/kg/min over 30 mins); and an LPS + L-NAME group (n = 5) receiving endotoxin and, 1 hr after, a bolus of L-NAME (25 mg/kg). MEASUREMENTS AND MAIN RESULTS: Hemodynamic changes, usual coagulation parameters, and plasma concentrations of thrombin-antithrombin complexes, antithrombin III activity (At III), tissue plasminogen activator, plasminogen activator inhibitor type 1, and von Willebrand factor were measured at baseline, and at 30, 60, 90, 120, 180, 240, and 300 mins. After euthanasia or death, lungs and kidneys were withdrawn for histologic study. The extent of microvascular thrombosis was assessed by a semiquantitative disseminated intravascular coagulation score. In both septic endotoxin group, administration of LPS resulted in hemodynamic changes typical of severe septic shock, with disseminated intravascular coagulation and histologic changes characterized by adult respiratory distress syndrome and kidney microthrombosis. L-NAME administration normalized mean arterial pressure with a dramatic increase in systemic vascular resistances and a marked decrease in cardiac index. The changes in usual coagulation parameters, AT III, tissue plasminogen activator, and plasminogen-activator inhibitor type 1 concentrations were not different between both septic groups. However, in the LPS + L-NAME group, thrombin-antithrombin complexes and von Willebrand factor were higher and associated with a higher histologic disseminated intravascular coagulation score. CONCLUSION: In this model of endotoxin septic shock, L-NAME administration resulted in histologic and coagulation changes consistent with an increased activation of intravascular coagulation.

Animals↗
PubMed1997

Epithelioid sarcoma of the tongue.

A case of epithelioid sarcoma in the tongue is reported. The patient, a 35 year old woman, presented with a non-ulcerated painful lesion of the tongue. Microscopically, the tumour was characterised by multiple coalescent nodules with central geographic necrosis infiltrating the lingual muscle. The tumour cells were epithelioid with abundant eosinophilic cytoplasm and atypical nuclei. Immunohistochemically, the tumour cells stained for vimentin, keratin, and epithelial membrane antigen. These morphological and immunohistochemical appearances led to the diagnosis of epithelioid sarcoma of the tongue. Seven years later, the patient died with metastatic dissemination to the scalp, lungs, and brain. No case of epithelioid sarcoma arising in the tongue has been described previously.

Adult↗
PubMed1997

[Juvenile xanthogranuloma localized in the parotid gland].

Juvenile xanthogranuloma of parotid gland is reported in a 9-year-old boy. This kind of tumor is thought to be very rare in salivary glands. Histological, immunohistochemical and ultrastructural data showed characteristic features and excluded a Langerhans cell histiocytosis. Follow-up was uneventful after 18 months.

Child↗
PubMed1997

[Multifocal epithelioid angiosarcoma of the small intestine. Apropos of a case].

A case of angiosarcoma in the small bowel is reported. There were multifocal lesions in the duodeno-jejunum with peritoneal metastasis, revealed by an hemorrhagic syndrome. This tumor rare in the gastro-intestinal tract was epithelioïd. The authors present an histochemical and immunohistochemical study with a review of the literature.

Aged↗
PubMed1985

The diffusion of a vanguard technique: the case of nuclear medicine in Belgium.

How does a new technology spread across a country? Which are the factors influencing its spreading across time and space? We have attempted to answer to those questions through the example of nuclear medicine. We have used a macro-economic approach, based on regional and diachronic data (43 areas and three larger 'regions' from 1974 to 1982). Two separate fields have taken advantage of the use of radioisotopes: in vivo and in vitro tests. The rates of growth of those two techniques have been completely different and their future evolution will probably also be in sharp contrast. On the contrary, the regional distribution of the utilization rates is similar in both fields: it seems related to the density of specialists who are accessible for the patients and also to the regional ways of practice which feature the prescription of other types of tests.

Belgium↗
PubMed1984

Home care as an alternative to hospitalization: a case study in Belgium.

In Belgium, primary health care services are well developed. Their efficiency is, however, handicapped by a general lack of coordination at a local level. Recently, pilot projects have been conducted to improve the integration of the various activities related to the practice of family medicine and especially those activities associated with the home care of chronic diseases and disabilities of the elderly. In one municipality where the coordination of primary care services is organized from a health centre, a retrospective study was carried out to measure the possible effect of such coordination on the use of health services. Indicators of the use of medical services were measured before and after the establishment of the coordinating centre, and were compared with the evolution observed in control areas. It is shown that the establishment of a health centre and the coordination of existing activities do not result in an inflationary use of primary care services. Moreover, the use of secondary care services seems to be reduced, indicating a net benefit in terms of costs.

Belgium↗