Biomedical subjects

X Lian

Publications and source records attributed to X Lian.

11 recordsLinked to original sources

PubMed2004

NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine.

The synthetic compound NO-1886 (ibrolipim) is a lipoprotein lipase activator that has been proven to be highly effective in lowering plasma triglycerides. Recently, we found that NO-1886 also reduced plasma free fatty acids and glucose in high-fat/high-sucrose diet-induced diabetic rabbits. In the current study, we investigated the effects of NO-1886 treatment on ectopic lipid deposition and the islet pathology in miniature swine fed a high-fat/high-sucrose diet. Our results showed that feeding this diet to miniature swine caused insulin resistance, increased lipid deposition in non-adipose tissue, such as in the heart, skeletal muscle, liver and pancreas, and also caused pancreatic beta cell damage. However, supplementing 1% NO-1886 (200 mg/kg per day) into the high-fat/high-sucrose diet decreased ectopic lipid deposition, improved insulin resistance, and alleviated the beta cell damage. These results suggest that improvement of lipid disorder, non-adipose tissue steatosis and insulin resistance may be very important for the protection of beta cell damage. Therefore, NO-1886 is potentially beneficial for the treatment of insulin-resistance syndrome.

Animals↗

PubMed2001

[Dual sieve-mesh collimator].

In this paper is advanced a new type of collimator-dual sieve-mesh collimator. Its principle is to use scanned electronic beam to attack 400 matrix-arranged wolfram targets of the square holes on the upper side of the main collimator and created 400 small X-ray fields sized by 10 mm x 10 mm. These X-ray fields will leave on its center 400 smaller X-ray fields sized by 5 mm x 5 mm after being further collimated by a sub-collimator. What's more, 16 different groups of such X-ray fields can be left on the center of the same field by controlling the all-round movement of the main collimator and sub-collimator in proper order and by scanning it round by round and mesh by mesh with electronic beams. It is these ting fields groups that make up various treatment fields with different energy (Dosage). This type of collimator can replace and simplify all other present collimators on accelerators and conformal-intensity modulation radiotherapy equipment. It has advantage of reducing the costs of radio-therapy equipment and making conformal and intensity modulation radiotherapy easier to perform.

Equipment Design↗

PubMed2001

[Dual copy-supplement collimator].

Dual Copy-Supplement Collimator consists of two lead conic sections centered on one common radioactive source and having a lot of small square holes on them. When scanning electron beams strike X-Ray target and create some X-Ray fields while passing through the primary section, they penetrate the secondary section and generate even smaller field units(FU). Using these FUs would compose various treatment fields with different energy (dosage). It is able not only to replace many existing collimators such as MLC, but also to make the conformal radiotherapy easier.

Equipment Design↗

PubMed2000

[Detection of remnants after removal of medullary thyroid carcinoma].

OBJECTIVE: To assess whether calcium stimulation test or somatostain-receptor (SS-R) imaging could early detect remnants after removal of medullary thyroid carcinoma (MTC). METHODS: Calcitonin stimulation (calcium element 3 mg/kg weight, i.v. 10 min), carcino-embryonic antigen (CEA), gastrin (GST) and vasoactive intestinal peptide (VIP) were tested in 14 patients with postoperative MTC. SS-R imaging was used to localize the remnants after removal of MTC in patients with elevated calcitonin. RESULTS: Calcitonin stimulation test showed that the peak value of serum calcitonin was elevated in all patients, of whom 7 had the elevated vatue of basic calcitonin and peak calcitonin. In the 7 patients, SS-R imaging showed normal CEA, GST and VIP. CONCLUSIONS: It is necessary for patients after removal of MTC to perform calcitonin stimulation test for detecting remnants early. SS-R imaging may be useful for localizing remnants and metastatic foci. CEA, GST and VIP are not significant in monitoring MTC after operation.

Adult↗

PubMed2000

[Experiment study on fit of anterior osseointegrated implant frameworks related to the number of fixture abutments].

Good fitness of osseointegrated frameworks was a key factor to protect implant for function. The purpose of this study was to evaluate the fitness of anterior implant fixed bridge in one-piece casting made of Ni-Cr alloy in different numbers of fixture abutments. The specimens were measured by the three-dimensional measurement system (German Opton uMM550). The results demonstrated that there were statistically significant differences in dimensional changes among one, two or three fixture numbers, the space of retention was 50-150 microns, and the flow of retention was 100-250 microns.

Dental Abutments↗

PubMed2000

[A clinical study on coincidence with hyperthyroidism and thyroid carcinoma].

OBJECTIVE: A retrospective study has been carried out to evaluate the prevalence of coincidence with hyperthyroidism and thyroid carcinoma. METHODS: 394 patients underwent surgery for hyperthyroidism and 245 patients suffered from thyroid cancer were chosen for the study in our hospital from January 1983 to June 1998. RESULTS: Thyroid cancer and hyperthyroidism coincided in 12 patients. The incidence of thyroid cancer was 3.0% (12/394) in hyperthyroidism, and the incidence of hyperthyroidism was 4.9% in thyroid cancer. There were 7 female and 5 male, with a diffuse goiter (n = 3), a diffuse goiter with a cold nodule (n = 3), multinodular goiter (n = 6). Among the 12 patients, 7 patients had an occult thyroid cancer with a diameter of 1 cm or less, most of them with papillary carcinoma, less frequently had metastases, 4 patients had thyroid cancer with a diameter of 3 cm or more, and 3 patients had metastases. CONCLUSIONS: The prevalence of coincidence with thyroid cancer and hyperthyroidism is more than that of thyroid cancer in population. Diagnostics for exclusion of thyroid cancer is required carefully even in the presence of hyperthyroidism.

Female↗

PubMed1999

[Studies on the infrared and fluorescence spectra of europium lanthanum-benzoate complexes].

A series of mixed rare earth complexes of benzoic acid with europium and lanthanum were synthesized by the reaction of trivalent rare earth chlorides with ammonium benzoate in aqueous solution. Their composition is expressed with the general formula (Eu(1-chi)La(chi)) L3, where L = C6H5COO(-1), chi = 0.0-1.0. Their infrared and fluorescence spectra were investigated. The characteristic asymmetric (v(as)) and symmetric (v(s)) stretching vibrations of carboxyl group for rare earth complexes shift to lower frequency in comparison with sodium benzoate, and both the absorption bands show splitting. In addition, the difference between v(as) and v(s), deltav (120-125) cm(-1), is lees than that of sodium benzoate (deltav =137 cm(-1)). These situations show that the coordinating pattern of the carboxyl groups in the complexes is the form of chelation-bridging, therefore, it may be suggested that the rare earth (Eu, La) benzoates are a heteronuclear polymers. The dependence of the relative fluorescence intensity of the mixed rare earth complexes upon the content for La3+ ions was discussed. The results show that the emission intensity for Eu3+ ions can be greatly enhanced if a part of Eu3+ ions in europium benzoate were substituted by La3+ inos. When chi = 0.4, 0.5 or 0.7, the fluorescence intensity of the rare earth complexes can rise above 40%.

English Abstract↗

PubMed1998

[Effects of low concentration ozone on the respiratory system of mice].

Effects of low concentration of O3 on the respiratory system in mice were studied in the present study. Mice were exposed to 0.1, 0.25 and 1.0 mg/m3 of O3, respectively for 8 h per day for 3 days. Cilia in brochia, Lipid peroxide (LPO) in lung tissue and phagocytic function of macrophage in mice were examined. The results showed that there were cilia damage in the 1.0 mg/m3 group and swelling of mitochondrias as well as endoplasmic reticulums in the 0.25 mg/m3 group. But no damage was found in the group of 0.1 mg/m3. Furthermore, phagocytic rates in the 0.25 and 1.0 mg/m3 groups were significantly lower than that of control group (P < 0.01). No differences in LPO leads were found.

Animals↗

PubMed1998

[Effect of ginsenoside Rb1 on repeated stress-induced sexual deficiencies in male mice].

The effect of ginsenoside Rb1 has been studied on sexual deficiencies induced by repeated hanging stress. Male mice were stressed by hanging once daily(9:00 am-2:00 pm) for 10 days(1-3 day hung for 2 h, 4-6 day hung for 3 h, 7-9 day hung for 4 h, 10-11 day hung for 5 h). On day 10, they were exposed to female mice treated with estradiol and progesterone and their sexual behaviors (licking, mounting, mating) were assessed at 7:00-9:00 pm. The repeated hanging stress was found to reduce sexual behaviors and decrease plasma testosterone level in mice. Treatments with ginsenoside Rb1(2.5, 5, 10 mg.kg-1, i.p.) 30 min before each stress prevented the repeated stress-induced sexual deficiencies and raised plasma testosterone level. The mechanism of the protective action of ginsenoside Rb1 may be attributed to its action in maintaining normal plasma testosterone level.

Animals↗

PubMed1994

[A study of DNA damage induced by asbestos fibers in vitro].

The results of our in vitro study showed that Rhodesia chrysotile, X. K. chrysotile, UICC chrysotile, crocidolite and amosite could cause damage to calf thymus DNA by inducing the production of 8-hydroxy-2'-deoxyguanosine (8-OH-dG). After adding H2O2 and/or FeSO4, the production of 8-OH-dG, induced by asbestos fibers was significantly increased. The fiber of UICC crocidolite has the most untoward effect, that of UICC amosite comes next, and the three chrysotile fibers are the weakest ones. The effect of asbestos fibers on the production of 8-OH-dG has some relationship with hydroxy free radical and the type of asbestos. It is suggested that asbestos fibers could induce DNA point mutation through A.T and G.C transversion by the production of 8-OH-dG, which is related with the carcinogenesis of asbestos.

8-Hydroxy-2'-Deoxyguanosine↗

PubMed1992

Effect of hydroxyl radical on Na(+)-K(+)-ATPase activity of the brain microsomal membranes.

Sphingomyelin liposomes and brain microsomes were oxidized by exposure to hydrogen peroxide and ferrous ion. Lipid peroxidation were measured by the formation of thiobarbituric acid- reactive substances (TBAR). Hydroxyl radical was detected using the spin- trapping technique. Incubation of sphingomyelin liposomes with H2O2-Fe2+ resulted in an increase in the formation of TBAR. Na(+)-K(+)-ATPase activity was markedly inhibited and the SH group content decreased during incubation of microsomes in the presence of H2O2-Fe2+. Sodium ferulate effectively inhibited TBAR formation, protected Na(+)-K(+)-ATPase activity and prevented the oxidative modification of SH groups. Spin-trapping experiments showed that sodium ferulate effectively scavenged the hydroxyl radicals.

Animals↗