Biomedical subjects

X M Xue

Publications and source records attributed to X M Xue.

2 recordsLinked to original sources

PubMed1993

[Study on the T cell functions induced by anti-CD3mAb in chronic pulmonary heart disease].

We studied the T lymphocyte transformation and IL-2's functions induced by anti-CD3 mAb in 42 cases of CPHD. The T lymphocyte transformation, activity of IL-2 and expression of IL-2R were determined by 3H-TDR incorporation, bioassay and immunoabsorption methods. The results showed that PBL transformation and activity of IL-2 were decreased in the patients of acute exacerbation stage more than those in controls and remission stage (P < 0.05 or P < 0.01); activity of IL-2 in the patients of remission stage was close to that in controls (P > 0.05), but PBL transformation was still less than that in controls (P < 0.01); Expression of IL-1R were increased in the patients more than in controls (P < 0.01). G.I of anti-CD3mAb and PHA stimulating PBL proliferation showed positive correlation (P < 0.01), activity of IL-2 and expression of IL-2R were not correlated (P > 0.05). The results showed that extrinsic IL-2 could enhance PBL proliferations induced by anti-CD3mAb, especially in CPHD patients.

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PubMed1983

The gravitational field and brain function.

The frontal cortex is recognized as the highest adaptive control center of the human brain. The principle of the "frontalization" of human brain function offers new possibilities for brain research in space. There is evolutionary and experimental evidence indicating the validity of the principle, including it's role in nervous response to gravitational stimulation. The gravitational field is considered here as one of the more constant and comprehensive factors acting on brain evolution, which has undergone some successive crucial steps: "encephalization", "corticalization", "lateralization" and "frontalization". The dominating effects of electrical responses from the frontal cortex have been discovered 1) in experiments under gravitational stimulus; and 2) in processes potentially relating to gravitational adaptation, such as memory and learning, sensory information processing, motor programing, and brain state control. A brain research experiment during space flight is suggested to test the role of the frontal cortex in space adaptation and it's potentiality in brain control.

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