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X Matias-Guiu

Publications and source records attributed to X Matias-Guiu.

At least 91 records · Page 5Linked to original sources
PubMed1991

Simultaneous carcinoma involving the endometrium and the ovary. A clinicopathologic, immunohistochemical, and DNA flow cytometric study of 18 cases.

Eighteen carcinomas involving both the endometrium and the ovary were studied. Stage, size, bilaterality and pattern of ovarian involvement, histologic types and grades, presence of endometrial hyperplasia or ovarian endometriosis, myometrial, tubal, lymphatic and blood vessel invasion, and follow-up of the patients were all evaluated. Accordingly, the cases were classified as follows: Group A (nine cases), two separate primary tumors; and Group B (nine cases), uterine primaries with ovarian metastasis or ovarian primaries with uterine metastasis. Immunohistochemical stains (CAM 5.2, wide-spectrum keratin, vimentin, carcinoembryonic antigen (CEA), CA 12.5, CA 19.9) were performed in all cases. Flow cytometric determination of nuclear DNA was done in 13 (seven Group A and six Group B tumors). Of the nine cases with independent primary tumors, seven showed different immunohistochemical profiles in the ovarian and uterine tumors, whereas only four of the nine metastatic ones had similar staining characteristics. Five cases with independent primary tumors, but only one of the metastatic group, exhibited different aneuploid stemlines in the endometrial and ovarian tumors. The other seven (two independent and five metastatic) cases had similar DNA indexes in both tumors. Immunohistochemical and DNA flow cytometric study may be of some value for the distinction between metastatic and independent tumors, but differential diagnosis must presently rely largely upon conventional clinicopathologic criteria.

Adenocarcinoma↗
PubMed1991

Immunohistochemical study of sarcoma-like mural nodules in a mucinous cystadenocarcinoma of the ovary.

We describe an ovarian mucinous cystadenocarcinoma with several sarcoma-like mural nodules (SLMN). The distinction between these lesions and foci of anaplastic carcinoma is important because of the poor prognosis of the latter. We have studied the potential value of immunohistochemistry in the differential diagnosis of these two lesions. In contrast to an anaplastic carcinoma, which was largely composed of keratin-positive cells, SLMN were negative or only focally positive. Therefore, in distinguishing SLMN from foci of anaplastic carcinoma, keratin strains may be added to other gross and microscopical differential features, such as size, demarcation, and presence or lack of obvious carcinomatous elements.

Adult↗
PubMed1991

Lymphoepithelial lesion in the thyroid. A non-specific histological finding.

In order to assess the specificity of lymphoepithelial lesion (LEL) in the diagnosis of thyroid lymphoma, the thyroid glands of patients with Hashimoto's disease, lymphoid infiltrates in the vicinity of papillary carcinoma, focal thyroiditis in Graves' disease and malignant lymphoma of the thyroid were studied by conventional pathological and immunohistochemical techniques using a panel of antibodies against epithelial cells (CAM 5.2) and leucocytes (LCA, pan-T, and pan-B antisera). LEL was encountered in all cases. In cases of peritumoral lymphoid infiltrates LEL represented a focal phenomenon, whereas in Hashimoto's and Graves' diseases and lymphoma, it was found in multiple areas. In cases of malignant lymphoma LEL was encountered in the vicinity of areas where diffuse parenchymal destruction by tumor cells had occurred. The results suggested that although LEL is almost always present in lymphomas it can also be encountered in other diseases of the thyroid. If therefore LEL has no diagnostic specificity, the diagnosis of malignant lymphoma must be supported by other histological findings.

Carcinoma, Papillary↗
PubMed1991

Keratin expression in normal vulva, non-neoplastic epithelial disorders, vulvar intraepithelial neoplasia, and invasive squamous cell carcinoma.

The expression of AE1, AE2, AE3, and CAM 5.2 antikeratin monoclonal antibodies was investigated in 68 vulvar specimens by an avidin-biotin complex (ABC) method. They included normal vulva (NV, 10), non-neoplastic epithelial disorders (NNED, 31), vulvar intraepithelial neoplasia (VIN, 17), and squamous cell carcinoma (SCC, 10). AE1 weakly stained the basal cell layer in NV, exhibited a uniform suprabasal stain in hyperplasia, failed to stain dysplastic areas in VIN I-II, and was patchy and disorganized in VIN III and SCC. AE2 stained the upper third of the epithelium in NV, NNED, and VIN I-II, but it failed to stain VIN III basaloid and SCC; VIN III bowenoid was focally positive. AE3 offered little information, because it stained all lesions; VIN III and SCC, however, exhibited a patchy and disorganized stain. CAM 5.2 was expressed in only half of the cases of VIN III basaloid and in one case each of VIN I-II and SCC. We conclude that keratin expression varies according to the degree of dysplasia; AE1 may serve to separate certain cases of NNED from VIN I-II; AE2 and CAM 5.2 are useful to differentiate both histologic types of VIN III.

Antibodies, Monoclonal↗
PubMed1990

Ovarian tumors with functioning stroma. An immunohistochemical study of 100 cases with human chorionic gonadotropin monoclonal and polyclonal antibodies.

The frequency of stromal activation and its possible relation to human chorionic gonadotropin (HCG) or HCG-like secretion by tumor cells has been studied in 100 nonselected, consecutive, primary and secondary ovarian neoplasms. Stromal luteinization was present in 13 cases and stromal condensation in 16. The types of tumors most commonly associated with activation of the ovarian stroma were as follows: mucinous tumors (11 cases), endometrioid and clear cell tumors (six cases), and metastasis of gastrointestinal adenocarcinomas (six cases). We used to commercial polyclonal antibodies as well as four more specific monoclonal antibodies (FBT-10, FBT-11, FB-12, and FB-13). Immunohistochemical studies (peroxidase-antiperoxidase [PAP]) yielded the following staining results: polyclonal HCG and/or polyclonal beta-HCG positivity was present in 22 tumors (12 had an activated stroma and ten an inactive one). In addition, 44 tumors were positive for FBT-10, FBT-11, FB-12, and FB-13 monoclonal antibodies (18 showed activation of the stroma, which was inactive in 26). Only 11 of the 56 HCG-negative tumors exhibited activation of the stroma. Thus, positivity for HCG was more frequently found in tumors with morphologically active stroma than in those with an inactive one. However, five HCG polyclonal positive tumors--three of them exhibiting activation of the stroma--were negative for the monoclonal antibodies. It appears that HCG plays a role in the activation of the stroma of some ovarian tumors, yet, HCG-like substances as well as other factors may also be involved.

Adenocarcinoma↗
PubMed1990

Cavernous angiomas of the cranial nerves. Report of two cases.

Two cavernous hemangiomas arising in the third and eighth cranial nerves, respectively, and presenting as space-occupying lesions are reported. The tumors posed problems in the preoperative differential diagnosis. The main clinicopathological features of these tumors are discussed.

Adult↗
PubMed1990

[Subcutaneous nodules and sensitivity to aluminum in patients undergoing hyposensitivity immunotherapy].

Hypersensitivity reactions to aluminium are very rate. Sensitization has been reported to occur during continuous application of aluminium-containing antiperspirants or by aluminium adjuvants in vaccines and hyposensitization immunotherapy. We report 5 patients who developed persistent and itching subcutaneous nodules following immunotherapy. Histologically, the nodules showed a granulomatous reaction consistent with delayed hypersensitivity to aluminium. Patch tests with 2% aluminium chloride in water were positive in three patients, and positive results of patch test with other metals (nickel, cobalt) were frequently associated.

Adult↗
PubMed1989

Echogenic focus in the gastrointestinal wall as a sign of ulceration.

An ultrasound study carried out on 22 patients with ulcerated gastrointestinal lesions (20 adenocarcinomas and 2 peptic ulcers) showed, in all cases, an echogenic focus (EF) that was situated in the gastrointestinal wall. In order to find out the histopathologic significance of this focus and its location, an examination was made "in vitro" of 8 surgical specimens obtained from gastrectomies--6 from peptic and 2 from malignant ulcers. The specimens were immersed in a water bath using a 5-MHz transducer. A common finding in all the specimens was an EF similar to that seen in the clinical study and situated behind the crater of the ulcer. In this location the histopathologic findings demonstrated necrotic and inflammatory material in both the benign and malignant lesions.

Adenocarcinoma↗
PubMed1989

Hepatoid gastric adenocarcinoma.

A case of hepatoid gastric adenocarcinoma is reported. The tumor had the histological and immunohistochemical features of both liver cell carcinoma and conventional intestinal-type adenocarcinoma. We discuss the main clinical and pathological features of this uncommon variety of gastric cancer.

Adenocarcinoma↗
PubMed1988

Surgical gauze pseudotumor.

Gauze forgotten at operations can be potentially life threatening, but such cases are seldom reported because of the medicolegal implications. We have presented a series of seven patients with long-term surgical gauze retention, four after pelvic operations, one after cholecystectomy, one after laryngectomy, and one after mastectomy. The median time interval between operation and gauze removal was 5 years. In three patients this was diagnosed as a tumoral mass, in three as an intestinal occlusion, and in one the gauze was found incidentally. All foreign bodies were removed and no patient died. The clinical and diagnostic aspects of retained surgical gauze have been discussed and the need for radiopaque markers in them have been emphasized.

Bandages↗
PubMed1988

ABO (H) blood group antigen expression in gastric mucosa.

The A, B, O (H) blood group antigens (BGA) are glycolipids present in the plasma membranes of many different epithelial cells. Alterations in BGA expression have been described in malignant tumors and premalignant lesions. We have studied ABO (H) BGA expression in paraffin sections of gastric specimens using immunofluorescence techniques with monoclonal antibodies. 102 patients were studied. 15 with normal mucosa (NM); 16 with duodenal ulcer (DU); 23 with gastric ulcer (GU); 11 with pernicious anaemia (PA) and 37 with adenocarcinoma (AC). The expression of BGA in normal gastric mucosa is detected in surface epithelium, mucoid cell neck glands and parietal cells as well as 2/3 of antral glands. BGA expression in DU gastritis is very similar to that seen in NM. In atrophic chronic gastritis associated with GU and PA there is a significant decrease in BGA expression. In patients with PA, BGA expression is greater in antral mucosa than in fundic mucosa. Loss of BGA expression is more pronounced in atrophic chronic gastritis surrounding AC. Intestinal metaplasia shows variable BGA expression. Our results support the hypothesis that loss of BGA expression by epithelial gastric mucosal cells may be related to alterations in cellular differentiation and premalignant potential.

ABO Blood-Group System↗
PubMed1988

Villous adenoma of the prostatic urethra.

We present a case of villous adenoma of the prostatic urethra, without malignant transformation. A review of the diagnostic and therapeutic criteria and pathogenic hypotheses on this kind of lesion in the lower urinary tract are made.

Adenoma↗
PubMed1988

Meningo-angiomatosis: a case report.

We report a case of Meningo-angiomatosis, a rare hamartomatous lesion of the cerebral cortex. The main clinical and pathological features of this entity are discussed.

Adult↗
PubMedDate not supplied

Endomyocardial diagnosis of cardiac lipomatosis.

A patient with severe isolated right-sided cardiac failure of unknown origin is presented in whom three right ventricular endomyocardial biopsies obtained in different bioptome positions disclosed a yellowish material which was confirmed at histological examination as fat. At operation, a complete replacement of atrial and ventricular myocardium by fat was noted. this previously unreported use of endomyocardial biopsy is emphasized, especially when the differential diagnosis of isolated right-sided heart failure is considered.

Biopsy↗
PubMedDate not supplied

[Usefulness of RET proto-oncogene in the diagnosis of hereditary-type medullary carcinoma of the thyroid. Correlation with surgical findings].

In about 25% of cases medullary thyroid carcinoma (MTC) is hereditary. In this group is possible to detect germline point mutations of the RET proto-oncogene in about 95% of the studied cases. The purpose of the present paper is to confirm the value of the RET in the screening of the hereditary MTC. We studied 43 subjects at risk for a Multiple Endocrine Neoplasia Type 2A Syndrome. RET analysis was positive for MEN 2A in 22 subjects. Fifteen of the 22 have undergone a total thyroidectomy at our facility. Histopathological study of the surgical specimens confirmed the presence of a MTC in all the cases. According with our experience. RET analysis is a 100% sensitive and specific method of hereditary MTC screening, and we think it has obvious advantages over the calcitonin tests in technical, economic and ethic aspects.

Adolescent↗