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Biomedical subjects

X Pastor Durán

Publications and source records attributed to X Pastor Durán.

9 recordsLinked to original sources
PubMed1993

[Guillain-Barre syndrome: a study of 13 children].

A group of 13 children, aged 2 to 14 years, and diagnosed with Guillain-Barré syndrome has been analyzed. Clinical features and outcome were retrospectively studied. In 75% of the patients there was an infectious illness previous to the neurologic symptoms and in four children the etiologic agent was demonstrated. Motor deficits affecting the limbs and muscle stretch reflexes were absent in all thirteen patients. Cranial nerve involvement showed-up in 46%. Meningitic symptoms occurred in 62% of the cases. One of the children developed the Fisher syndrome variant. Two patients required assisted ventilation. Three children showed associated immunologic abnormalities, with one of the patients having a selective IgA deficiency, another child showing an increment in IgE and the other Kawasaki syndrome. We have not demonstrated differences in the outcome between the patients with corticoid treatment.

Adolescent↗
PubMed1993

[Hemolytic uremic syndrome. Evaluation of clinical and prognostic factors].

Ten patients with hemolytic uremic syndrome (HUS) were admitted to our ICU during the last 7 years. The mean age at entry was 26 month old. Only one child was more than 2 years of age. A greater incidence of this illness was noted during the summer season. Almost all cases (90%), were severe with arterial hypertension and requiring peritoneal dialysis. HUS is a multisystemic disorder with early renal involvement, but the possibility of other sites being affected must be kept in mind. Half of the patients presented extrarenal manifestations of disease, including: seizures (30%), colonic ischemia requiring intestinal resection, and heart failure with lung edema due to severe hypertension. The two parameters that were helpful in determining the prognosis were the interval of renal insufficiency (greater than 14 days) and neurologic impairment, with the later being of most importance.

Blood Transfusion↗
PubMed1990

[Diagnostic methodology of genome alteration].

Advances in molecular biology have produced great results concerning with the knowledge about hereditary mechanisms and gene diseases. In the last twenty years the development of discoveries have exceeded the information of clinical pediatricians, and the technology of genetic engineering, evolved from the properties of the DNA molecule, give us powerful diagnostic tools much more specific than those of classical cytogenetics limited to gross disorders of cariotype. Cellular cultures, autoradiography and electrophoresis have been very useful to develop molecular genetics. Using hybridomas a gene can be located into one chromosome. After wards the restriction map may be represented and employed as routine diagnostic procedure. Final objective is the genetic map with the complete sequence of normal and abnormal genes. To do so, more sophisticated methods are coming that still belong to the field of research.

Child↗
PubMed1987

[Newborn infants of diabetic mothers. Clinical study in the period 1980-1985].

An statistical analysis is reported on specific problems of the infant of diabetic mother during the period 1980-1985, with a total of 287 newborns. Complications in this sample are exposed, and significant differences demonstrated in gestational age, fetal distress, hypocalcemia, polycythemia, jaundice, respiratory distress syndrome and associated problems according to clinical type of diabetes mellitus. High percentage of congenital malformations is pointed-out with a predominance of cardiac septal defects. Diabetological control was closer in insulin-dependent group, therefore, its effect has been studied separately. A lower rate of hypoglycemia was found in those under control, while infant of insulin-dependent diabetic mother showed a better compliance between weight and gestational age and a lower rate of respiratory distress syndrome.

Adult↗